scholarly journals Dominant Negative Function by an Alternatively Spliced Form of the Interferon-inducible Protein Kinase PKR

2001 ◽  
Vol 276 (17) ◽  
pp. 13881-13890 ◽  
Author(s):  
Suiyang Li ◽  
Antonis E. Koromilas
Keyword(s):  
Protein Kinase ◽  
Dominant Negative ◽  
Negative Function ◽  
Alternatively Spliced ◽  
Inducible Protein ◽  
Interferon Inducible Protein

scholarly journals Nuclear Localization of the Interferon-Inducible Protein Kinase PKR in Human Cells and Transfected Mouse Cells

1995 ◽  
Vol 218 (1) ◽  
pp. 17-27 ◽  
Author(s):  
Ian W. Jeffrey ◽  
Suzanne Kadereit ◽  
Eliane F. Meurs ◽  
Thomas Metzger ◽  
Michael Bachmann ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Nuclear Localization ◽  
Human Cells ◽  
Mouse Cells ◽  
Inducible Protein ◽  
Interferon Inducible Protein

scholarly journals LPS-TLR4 Signaling to IRF-3/7 and NF-κB Involves the Toll Adapters TRAM and TRIF

2003 ◽  
Vol 198 (7) ◽  
pp. 1043-1055 ◽  
Author(s):  
Katherine A. Fitzgerald ◽  
Daniel C. Rowe ◽  
Betsy J. Barnes ◽  
Daniel R. Caffrey ◽  
Alberto Visintin ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Adaptor Protein ◽  
Dominant Negative ◽  
Tlr4 Signaling ◽  
Tir Domain ◽  
Toll Receptor ◽  
Inducible Protein ◽  
Myeloid Differentiation Factor ◽  
Lps Signaling ◽  
Interferon Inducible Protein

Toll–IL-1–resistance (TIR) domain–containing adaptor-inducing IFN-β (TRIF)–related adaptor molecule (TRAM) is the fourth TIR domain–containing adaptor protein to be described that participates in Toll receptor signaling. Like TRIF, TRAM activates interferon regulatory factor (IRF)-3, IRF-7, and NF-κB-dependent signaling pathways. Toll-like receptor (TLR)3 and 4 activate these pathways to induce IFN-α/β, regulated on activation, normal T cell expressed and secreted (RANTES), and γ interferon–inducible protein 10 (IP-10) expression independently of the adaptor protein myeloid differentiation factor 88 (MyD88). Dominant negative and siRNA studies performed here demonstrate that TRIF functions downstream of both the TLR3 (dsRNA) and TLR4 (LPS) signaling pathways, whereas the function of TRAM is restricted to the TLR4 pathway. TRAM interacts with TRIF, MyD88 adaptor–like protein (Mal)/TIRAP, and TLR4 but not with TLR3. These studies suggest that TRIF and TRAM both function in LPS-TLR4 signaling to regulate the MyD88-independent pathway during the innate immune response to LPS.

scholarly journals Activation of the interferon-inducible protein kinase PKR by Hepatocellular carcinoma derived-Hepatitis C virus core protein

Oncogene ◽  
2001 ◽  
Vol 20 (41) ◽  
pp. 5836-5845 ◽  
Author(s):  
Nadvia Delhem ◽  
Abdelmajid Sabile ◽  
Rodrigo Gajardo ◽  
Philippe Podevin ◽  
Annie Abadie ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Protein Kinase ◽  
Core Protein ◽  
Virus Core ◽  
Inducible Protein ◽  
Interferon Inducible Protein

scholarly journals Human Interferon-γ mRNA Autoregulates Its Translation through a Pseudoknot that Activates the Interferon-Inducible Protein Kinase PKR

Cell ◽  
2002 ◽  
Vol 108 (2) ◽  
pp. 221-232 ◽  
Author(s):  
Yitzhak Ben-Asouli ◽  
Yona Banai ◽  
Yehuda Pel-Or ◽  
Alexei Shir ◽  
Raymond Kaempfer
Keyword(s):  
Protein Kinase ◽  
Interferon Γ ◽  
Human Interferon ◽  
Inducible Protein ◽  
Interferon Inducible Protein
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