scholarly journals Synergistic Activation of Caspase-3 by m-Calpain after Neonatal Hypoxia-Ischemia

2000 ◽  
Vol 276 (13) ◽  
pp. 10191-10198 ◽  
Author(s):  
Klas Blomgren ◽  
Changlian Zhu ◽  
Xiaoyang Wang ◽  
Jan-Olof Karlsson ◽  
Anna-Lena Leverin ◽  
...  
Keyword(s):  
Caspase 3 ◽  
Neonatal Hypoxia ◽  
Synergistic Activation ◽  
Hypoxia Ischemia

Effect of hyperbaric oxygen on apoptosis in neonatal hypoxia-ischemia rat model

2003 ◽  
Vol 95 (5) ◽  
pp. 2072-2080 ◽  
Author(s):  
John W. Calvert ◽  
Changman Zhou ◽  
Anil Nanda ◽  
John H. Zhang
Keyword(s):  
Hyperbaric Oxygen ◽  
Caspase 3 ◽  
Apoptotic Cell ◽  
Neuroprotective Effect ◽  
Parp Cleavage ◽  
Artery Ligation ◽  
Neonatal Hypoxia ◽  
Rat Pups ◽  
Hypoxia Ischemia ◽  
Expression And Activity

We have previously demonstrated that a transient exposure to hyperbaric oxygen (HBO) attenuated the neuronal injury after neonatal hypoxia-ischemia. This study was undertaken to determine whether HBO offers this neuroprotection by reducing apoptosis in injured brain tissue. Seven-day-old rat pups were subjected to unilateral carotid artery ligation followed by 2 h of hypoxia (8% oxygen). Apoptotic cell death was examined in the injured cortex and hippocampus tissue. Caspase-3 expression and activity increased at 18 and 24 h after the hypoxia-ischemia insult. At 18-48 h, poly(ADP-ribose) polymerase (PARP) cleavage occurred, which reduced the band at 116 kDa and enhanced the band at 85 kDa. There was a time-dependent increase in the number of terminal deoxynucleotidyltransferase-mediated dUTP nick end labeling (TUNEL)-positive cells. A single HBO treatment (100% oxygen, 3 ATA for 1 h) 1 h after hypoxia reduced the enhanced caspase-3 expression and activity, attenuated the PARP cleavage, and decreased the number of TUNEL-positive cells observed in the cortex and hippocampus. These results suggest that the neuroprotective effect of HBO is at least partially mediated by the reduction of apoptosis.

scholarly journals Differential activation of c-fos and caspase-3 in hippocampal neuron subpopulations following neonatal hypoxia-ischemia

2008 ◽  
Vol 86 (5) ◽  
pp. 1115-1124 ◽  
Author(s):  
Jayne M. Ness ◽  
Cary R. Harvey ◽  
Jason D. Washington ◽  
Kevin A. Roth ◽  
Steven L. Carroll ◽  
...  
Keyword(s):  
Hippocampal Neuron ◽  
Caspase 3 ◽  
Differential Activation ◽  
Neonatal Hypoxia ◽  
Hypoxia Ischemia

BDNF Blocks Caspase-3 Activation in Neonatal Hypoxia–Ischemia

2000 ◽  
Vol 7 (1) ◽  
pp. 38-53 ◽  
Author(s):  
Byung Hee Han ◽  
Anselm D'Costa ◽  
Stephen A. Back ◽  
Maia Parsadanian ◽  
Shilen Patel ◽  
...  
Keyword(s):  
Caspase 3 ◽  
Neonatal Hypoxia ◽  
Hypoxia Ischemia

NMDA blockade attenuates caspase-3 activation and DNA fragmentation after neonatal hypoxia–ischemia

Neuroreport ◽  
2000 ◽  
Vol 11 (13) ◽  
pp. 2833-2836 ◽  
Author(s):  
Malgorzata Puka-Sundvall ◽  
Ulrika Hallin ◽  
Changlian Zhu ◽  
Xiaoyang Wang ◽  
Jan-Olof Karlsson ◽  
...  
Keyword(s):  
Dna Fragmentation ◽  
Caspase 3 ◽  
Neonatal Hypoxia ◽  
Hypoxia Ischemia

Clusterin contributes to caspase-3–independent brain injury following neonatal hypoxia-ischemia

10.1038/85487 ◽  
2001 ◽  
Vol 7 (3) ◽  
pp. 338-343 ◽  
Author(s):  
Byung Hee Han ◽  
Ronald B. DeMattos ◽  
Laura L. Dugan ◽  
Jeong Sook Kim-Han ◽  
Robert P. Brendza ◽  
...  
Keyword(s):  
Brain Injury ◽  
Caspase 3 ◽  
Neonatal Hypoxia ◽  
Hypoxia Ischemia

scholarly journals Doxycycline Reduces Cleaved Caspase-3 and Microglial Activation in An Animal Model of Neonatal Hypoxia-Ischemia

2005 ◽  
Vol 25 (3) ◽  
pp. 314-324 ◽  
Author(s):  
Lauren L Jantzie ◽  
Po-Yin Cheung ◽  
Kathryn G Todd
Keyword(s):  
Animal Model ◽  
Microglial Activation ◽  
Time Course ◽  
Caspase 3 ◽  
Hippocampal Formation ◽  
Brain Regions ◽  
Dependent Manner ◽  
Neuroprotective Effects ◽  
Neonatal Hypoxia ◽  
Hypoxia Ischemia

Neonatal hypoxia-ischemia (HI) is a major contributor to many perinatal neurologic disorders and, thus, the search for therapies and effective treatments for the associated brain damage has become increasingly important. The tetracycline derivative, doxycycline (DOXY), has been reported to be neuroprotective in adult animal models of cerebral ischemia. To investigate the putative neuroprotective effects of DOXY in an animal model of neonatal HI, a time-course study was run such that pups received either DOXY (10 mg/kg) or VEH immediately before hypoxia, 1, 2, or 3 hours after HI ( n=6). At 7 days after injury, the pups were euthanized, and the brains were removed and processed for immunohistochemical and Western blot analyses using antibodies against specific markers for neurons, apoptotic markers, microglia, oligodendrocytes, and astrocytes. Results showed that in vulnerable brain regions including the hippocampal formation, thalamus, striatum, cerebral cortex and white matter tracts, DOXY significantly decreased caspase-3 immunoreactivity (a marker of apoptosis), promoted neuronal survival, inhibited microglial activation and reduced reactive astrocytosis compared with VEH-treated HI pups. These effects were found to occur in a time-dependent manner. Taken together, these results strongly suggest that doxycycline has potential as a pharmacological treatment for mild HI in neonates.

scholarly journals Activation of autophagy and Akt/CREB signaling play an equivalent role in the neuroprotective effect of rapamycin in neonatal hypoxia-ischemia

Autophagy ◽  
2010 ◽  
Vol 6 (3) ◽  
pp. 366-377 ◽  
Author(s):  
Silvia Carloni ◽  
Silvia Girelli ◽  
Claudia Scopa ◽  
Giuseppe Buonocore ◽  
Mariangela Longini ◽  
...  
Keyword(s):  
Neuroprotective Effect ◽  
Neonatal Hypoxia ◽  
Hypoxia Ischemia

scholarly journals The nonerythropoietic asialoerythropoietin protects against neonatal hypoxia-ischemia as potently as erythropoietin

2004 ◽  
Vol 91 (4) ◽  
pp. 900-910 ◽  
Author(s):  
Xiaoyang Wang ◽  
Changlian Zhu ◽  
Xinhua Wang ◽  
Jens Gammeltoft Gerwien ◽  
Andre Schrattenholz ◽  
...  
Keyword(s):  
Neonatal Hypoxia ◽  
Hypoxia Ischemia
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