An IntronicIkaros-binding Element Mediates Retinoic Acid Suppression of the Kappa Opioid Receptor Gene, Accompanied by Histone Deacetylation on the Promoters

Xinli Hu; Jing Bi; Horace H. Loh; Li-Na Wei

doi:10.1074/jbc.m005477200

An IntronicIkaros-binding Element Mediates Retinoic Acid Suppression of the Kappa Opioid Receptor Gene, Accompanied by Histone Deacetylation on the Promoters

Journal of Biological Chemistry ◽

10.1074/jbc.m005477200 ◽

2000 ◽

Vol 276 (7) ◽

pp. 4597-4603 ◽

Cited By ~ 28

Author(s):

Xinli Hu ◽

Jing Bi ◽

Horace H. Loh ◽

Li-Na Wei

Keyword(s):

Retinoic Acid ◽

Opioid Receptor ◽

Receptor Gene ◽

Kappa Opioid Receptor ◽

Histone Deacetylation ◽

Acid Suppression ◽

Kappa Opioid

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Epigenetic regulation of kappa opioid receptor gene in neuronal differentiation

Neuroscience ◽

10.1016/j.neuroscience.2007.12.015 ◽

2008 ◽

Vol 151 (4) ◽

pp. 1034-1041 ◽

Cited By ~ 12

Author(s):

S.W. Park ◽

Y. He ◽

S.G. Ha ◽

H.H. Loh ◽

L.-N. Wei

Keyword(s):

Neuronal Differentiation ◽

Opioid Receptor ◽

Epigenetic Regulation ◽

Receptor Gene ◽

Kappa Opioid Receptor ◽

Kappa Opioid

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Interleukin-6 Regulation of Kappa Opioid Receptor Gene Expression in Primary Sertoli Cells

Endocrine ◽

10.1385/endo:13:1:11 ◽

2000 ◽

Vol 13 (1) ◽

pp. 11-16 ◽

Cited By ~ 11

Author(s):

Shirzad Jenab ◽

Patricia L. Morris

Keyword(s):

Gene Expression ◽

Opioid Receptor ◽

Sertoli Cells ◽

Interleukin 6 ◽

Receptor Gene ◽

Kappa Opioid Receptor ◽

Kappa Opioid ◽

Receptor Gene Expression

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A variant on the kappa opioid receptor gene (OPRK1) is associated with stress response and related drug craving, limbic brain activation and cocaine relapse risk

Translational Psychiatry ◽

10.1038/tp.2013.62 ◽

2013 ◽

Vol 3 (8) ◽

pp. e292-e292 ◽

Cited By ~ 35

Author(s):

K Xu ◽

D Seo ◽

C Hodgkinson ◽

Y Hu ◽

D Goldman ◽

...

Keyword(s):

Stress Response ◽

Opioid Receptor ◽

Receptor Gene ◽

Brain Activation ◽

Kappa Opioid Receptor ◽

Kappa Opioid ◽

Relapse Risk ◽

Drug Craving ◽

Related Drug

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Redefinition of the human kappa opioid receptor gene (OPRK1) structure and association of haplotypes with opiate addiction

Pharmacogenetics ◽

10.1097/00008571-200412000-00002 ◽

2004 ◽

Vol 14 (12) ◽

pp. 793-804 ◽

Cited By ~ 70

Author(s):

Vadim Yuferov ◽

David Fussell ◽

K Steven LaForge ◽

David A Nielsen ◽

Derek Gordon ◽

...

Keyword(s):

Opioid Receptor ◽

Receptor Gene ◽

Kappa Opioid Receptor ◽

Opiate Addiction ◽

Kappa Opioid

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Analyses of polymorphisms of intron 2 of OPRK1 (kappa-opioid receptor gene) in association with opioid and cocaine dependence diagnoses in an African-American population

Neuroscience Letters ◽

10.1016/j.neulet.2021.136364 ◽

2021 ◽

pp. 136364

Author(s):

Vadim Yuferov ◽

Eduardo R. Butelman ◽

Matthew Randesi ◽

Jürg Ott ◽

Mary Jeanne Kreek

Keyword(s):

African American ◽

Opioid Receptor ◽

Receptor Gene ◽

Kappa Opioid Receptor ◽

Cocaine Dependence ◽

American Population ◽

Kappa Opioid ◽

African American Population ◽

Intron 2

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Epistatic effects between variants of kappa-opioid receptor gene and A118G of mu-opioid receptor gene increase susceptibility to addiction in Indian population

Progress in Neuro-Psychopharmacology and Biological Psychiatry ◽

10.1016/j.pnpbp.2011.10.018 ◽

2012 ◽

Vol 36 (2) ◽

pp. 225-230 ◽

Cited By ~ 32

Author(s):

Deepak Kumar ◽

Japashish Chakraborty ◽

Sumantra Das

Keyword(s):

Opioid Receptor ◽

Indian Population ◽

Receptor Gene ◽

Mu Opioid Receptor ◽

Kappa Opioid Receptor ◽

Kappa Opioid ◽

Mu Opioid ◽

Epistatic Effects

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Epigenetic regulation of the kappa opioid receptor gene by an insertion–deletion in the promoter region

European Neuropsychopharmacology ◽

10.1016/j.euroneuro.2017.12.013 ◽

2018 ◽

Vol 28 (2) ◽

pp. 334-340 ◽

Cited By ~ 5

Author(s):

Pierre-Eric Lutz ◽

Daniel Almeida ◽

Raoul Belzeaux ◽

Ipek Yalcin ◽

Gustavo Turecki

Keyword(s):

Opioid Receptor ◽

Epigenetic Regulation ◽

Promoter Region ◽

Receptor Gene ◽

Kappa Opioid Receptor ◽

Kappa Opioid

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Kappa Opioid Receptor Gene and the Regulatory Mechanisms of Its Protein Expression

The Opiate Receptors ◽

10.1007/978-1-60761-993-2_8 ◽

2010 ◽

pp. 181-194

Author(s):

Li-Na Wei ◽

Horace H. Loh

Keyword(s):

Protein Expression ◽

Opioid Receptor ◽

Receptor Gene ◽

Kappa Opioid Receptor ◽

Regulatory Mechanisms ◽

Kappa Opioid

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Localization of the Kappa Opioid Receptor Gene to Human Chromosome Band 8q11.2

Genomics ◽

10.1006/geno.1994.1117 ◽

1994 ◽

Vol 19 (3) ◽

pp. 596-597 ◽

Cited By ~ 22

Author(s):

Kazuki Yasuda ◽

Rafael Espinosa ◽

Jun Takeda ◽

Michelle M. Le Beau ◽

Graeme I. Bell

Keyword(s):

Human Chromosome ◽

Opioid Receptor ◽

Receptor Gene ◽

Kappa Opioid Receptor ◽

Chromosome Band ◽

Kappa Opioid ◽

Human Chromosome Band

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Disruption of the kappa -opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective kappa -agonist U-50,488H and attenuates morphine withdrawal

The EMBO Journal ◽

10.1093/emboj/17.4.886 ◽

1998 ◽

Vol 17 (4) ◽

pp. 886-897 ◽

Cited By ~ 285

Author(s):

F. Simonin

Keyword(s):

Opioid Receptor ◽

Visceral Pain ◽

Receptor Gene ◽

Kappa Opioid Receptor ◽

Morphine Withdrawal ◽

Kappa Opioid ◽

Kappa Agonist

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