scholarly journals Phorbol Ester-induced Expression of Airway Squamous Cell Differentiation Marker,SPRR1B, Is Regulated by Protein Kinase Cδ/Ras/MEKK1/MKK1-dependent/AP-1 Signal Transduction Pathway

2000 ◽  
Vol 275 (41) ◽  
pp. 32250-32259 ◽  
Author(s):  
Hue Vuong ◽  
Tricia Patterson ◽  
Paul Shapiro ◽  
Dhananjaya V. Kalvakolanu ◽  
Reen Wu ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Cell Differentiation ◽  
Protein Kinase ◽  
Squamous Cell ◽  
Phorbol Ester ◽  
Signal Transduction Pathway ◽  
Transduction Pathway ◽  
Induced Expression ◽  
Differentiation Marker ◽  
Protein Kinase Cδ

Far1 and Fus3 link the mating pheromone signal transduction pathway to three G1-phase Cdc28 kinase complexes

1993 ◽  
Vol 13 (9) ◽  
pp. 5659-5669 ◽  
Author(s):  
M Tyers ◽  
B Futcher
Keyword(s):  
Signal Transduction ◽  
Protein Kinase ◽  
Signal Transduction Pathway ◽  
Mitogen Activated Protein Kinase ◽  
G1 Phase ◽  
Transduction Pathway ◽  
Yeast Saccharomyces Cerevisiae ◽  
Alpha Factor ◽  
Mitogen Activated Protein

In the yeast Saccharomyces cerevisiae, the Cdc28 protein kinase controls commitment to cell division at Start, but no biologically relevant G1-phase substrates have been identified. We have studied the kinase complexes formed between Cdc28 and each of the G1 cyclins Cln1, Cln2, and Cln3. Each complex has a specific array of coprecipitated in vitro substrates. We identify one of these as Far1, a protein required for pheromone-induced arrest at Start. Treatment with alpha-factor induces a preferential association and/or phosphorylation of Far1 by the Cln1, Cln2, and Cln3 kinase complexes. This induced interaction depends upon the Fus3 protein kinase, a mitogen-activated protein kinase homolog that functions near the bottom of the alpha-factor signal transduction pathway. Thus, we trace a path through which a mitogen-activated protein kinase regulates a Cdc2 kinase.

scholarly journals Coupling of Cell Division and Differentiation in Arabidopsis thaliana Cultured Cells with Interaction of Ethylene and ABA Signaling Pathways

Life ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. 15
Author(s):  
Novikova ◽  
Stepanchenko ◽  
Zorina ◽  
Nosov ◽  
Rakitin ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Signal Transduction ◽  
Arabidopsis Thaliana ◽  
Cell Division ◽  
Cell Differentiation ◽  
Signal Transduction Pathway ◽  
Transduction Pathway ◽  
Aba Signaling ◽  
Exogenous Aba ◽  
Ethylene Signal

Recent studies indicate direct links between molecular cell cycle and cell differentiation machineries. Ethylene and abscisic acid (ABA) are known to affect cell division and differentiation, but the mechanisms of such effects are poorly understood. As ethylene and ABA signaling routes may interact, we examined their involvement in cell division and differentiation in cell tissue cultures derived from several Arabidopsis thaliana plants: wild type (Col-0), and ethylene-insensitive mutants etr1-1, ctr1-1, and ein2-1. We designed an experimental setup to analyze the growth-related parameters and molecular mechanisms in proliferating cells upon short exposure to ABA. Here, we provide evidence for the ethylene–ABA signaling pathways’ interaction in the regulation of cell division and differentiation as follows: (1) when the ethylene signal transduction pathway is functionally active (Col-0), the cells actively proliferate, and exogenous ABA performs its function as an inhibitor of DNA synthesis and division; (2) if the ethylene signal is not perceived (etr1-1), then, in addition to cell differentiation (tracheary elements formation), cell death can occur. The addition of exogenous ABA can rescue the cells via increasing proliferation; (3) if the ethylene signal is perceived, but not transduced (ein2-1), then cell differentiation takes place—the latter is enhanced by exogenous ABA while cell proliferation is reduced; (4) when the signal transduction pathway is constitutively active, the cells begin to exit the cell cycle and proceed to endo-reduplication (ctr1-1). In this case, the addition of exogenous ABA promotes reactivation of cell division.

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