scholarly journals The Kinase Activation Loop Is the Key to Mixed Lineage Kinase-3 Activation via Both Autophosphorylation and Hematopoetic Progenitor Kinase 1 Phosphorylation

2000 ◽  
Vol 276 (3) ◽  
pp. 1961-1967 ◽  
Author(s):  
Irene Wing-Lan Leung ◽  
Norman Lassam
Keyword(s):  
Activation Loop ◽  
Kinase Activation ◽  
Mixed Lineage Kinase ◽  
Mixed Lineage Kinase 3

scholarly journals Cdc42 Induces Activation Loop Phosphorylation and Membrane Targeting of Mixed Lineage Kinase 3

2005 ◽  
Vol 280 (52) ◽  
pp. 42984-42993 ◽  
Author(s):  
Yan Du ◽  
Barbara C. Böck ◽  
Karen A. Schachter ◽  
Mary Chao ◽  
Kathleen A. Gallo
Keyword(s):  
Membrane Targeting ◽  
Activation Loop ◽  
Mixed Lineage Kinase ◽  
Mixed Lineage Kinase 3

scholarly journals The association of the JNK scaffold protein, WDR62, with the mixed lineage kinase 3, MLK3

MAP Kinase ◽  
2015 ◽  
Vol 4 (1) ◽  
Author(s):  
Miriam Hadad ◽  
Sharon Aviram ◽  
Ilona Darlyuk-Saadon ◽  
Ksenya Cohen-Katsenelson ◽  
Alan J. Whitmarsh ◽  
...  
Keyword(s):  
Kinase Activity ◽  
Scaffold Protein ◽  
Scaffold Proteins ◽  
Wd40 Repeat ◽  
Jnk Pathway ◽  
Kinase Activation ◽  
Mixed Lineage Kinase ◽  
Mitogen Activated Protein ◽  
Mixed Lineage Kinase 3 ◽  
Novel Scaffold

Mitogen-activated protein kinases (MAPKs) form a kinase tier module in which MAPK, MAP2K and MAP3K are held by scaffold proteins. The scaffold proteins serve as a protein platform for selective and spatial kinase activation. The precise mechanism by which the scaffold proteins function has not yet been fully explained. WD40-repeat protein 62, WDR62 is a novel scaffold protein of the c-Jun N-terminal kinase (JNK) pathway. WDR62 is a 1523 a.a. long protein with no significant sequence homology to a known gene. Previously WDR62 was shown to associate with JNK and MKK4/7 in a modular fashion. Here, we show that WDR62 is able to associate with multiple members of the MAP3K of the mixed lineage kinase family and we map WDR62-MLK3 interacting domains. We identify two separable interacting domains within WDR62 and MLK3 proteins that can cross associate. MLK3 association with WDR62 is independent of JNK and MKK4/7 domains and activities. CDC42 activation disrupts WDR62-MLK3 association independent of MLK3 kinase activity.

scholarly journals Mixed Lineage Kinase 3 Mediates the Induction of CXCL10 by a STAT1-Dependent Mechanism During Hepatocyte Lipotoxicity

2017 ◽  
Vol 118 (10) ◽  
pp. 3249-3259 ◽  
Author(s):  
Kyoko Tomita ◽  
Ayano Kabashima ◽  
Brittany L. Freeman ◽  
Steven F. Bronk ◽  
Petra Hirsova ◽  
...  
Keyword(s):  
Mixed Lineage Kinase ◽  
Mixed Lineage Kinase 3 ◽  
Dependent Mechanism

scholarly journals Mixed lineage kinase 3 deficient mice are protected against the high fat high carbohydrate diet-induced steatohepatitis

2013 ◽  
Vol 34 (3) ◽  
pp. 427-437 ◽  
Author(s):  
Samar H. Ibrahim ◽  
Gregory J. Gores ◽  
Petra Hirsova ◽  
Michelle Kirby ◽  
Lili Miles ◽  
...  
Keyword(s):  
High Carbohydrate Diet ◽  
High Fat ◽  
Carbohydrate Diet ◽  
Mixed Lineage Kinase ◽  
High Carbohydrate ◽  
Mixed Lineage Kinase 3 ◽  
Deficient Mice

scholarly journals Role of the kinase activation loop on protein kinase C θ activity and intracellular localisation

FEBS Letters ◽  
2003 ◽  
Vol 554 (1-2) ◽  
pp. 35-40 ◽  
Author(s):  
Bianca Sparatore ◽  
Mario Passalacqua ◽  
Marco Pedrazzi ◽  
Sabina Ledda ◽  
Mauro Patrone ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Activation Loop ◽  
Kinase Activation ◽  
Kinase C ◽  
Intracellular Localisation

Mixed Lineage Kinase 3 phosphorylates prolyl-isomerase PIN1 and potentiates GLI1 signaling in pancreatic cancer development

2021 ◽  
Author(s):  
Navin Viswakarma ◽  
Gautam Sondarva ◽  
Daniel R. Principe ◽  
Rakesh Sathish Nair ◽  
Sandeep Kumar ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Development ◽  
Prolyl Isomerase ◽  
Mixed Lineage Kinase ◽  
Mixed Lineage Kinase 3

scholarly journals Transcriptional regulation of mixed lineage kinase 3 by estrogen and its implication in ER-positive breast cancer pathogenesis

Oncotarget ◽  
2017 ◽  
Vol 8 (20) ◽  
pp. 33172-33184 ◽  
Author(s):  
Navin Viswakarma ◽  
Rakesh Sathish Nair ◽  
Gautam Sondarva ◽  
Subhasis Das ◽  
Lucas Ibrahimi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Transcriptional Regulation ◽  
Mixed Lineage Kinase ◽  
Cancer Pathogenesis ◽  
Er Positive ◽  
Mixed Lineage Kinase 3 ◽  
Positive Breast Cancer
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