scholarly journals Human TREK2, a 2P Domain Mechano-sensitive K+Channel with Multiple Regulations by Polyunsaturated Fatty Acids, Lysophospholipids, and Gs, Gi, and GqProtein-coupled Receptors

2000 ◽  
Vol 275 (37) ◽  
pp. 28398-28405 ◽  
Author(s):  
Florian Lesage ◽  
Cécile Terrenoire ◽  
Georges Romey ◽  
Michel Lazdunski
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
K Channel

scholarly journals Inhibitory effects of polyunsaturated fatty acids on Kv4/KChIP potassium channels

2009 ◽  
Vol 296 (5) ◽  
pp. C1003-C1014 ◽  
Author(s):  
Linda M. Boland ◽  
Michelle M. Drzewiecki ◽  
Gabriela Timoney ◽  
Erin Casey
Keyword(s):  
Fatty Acids ◽  
Potassium Channels ◽  
Polyunsaturated Fatty Acids ◽  
Time Course ◽  
Expression System ◽  
K Channel ◽  
Xenopus Laevis Oocyte ◽  
Inhibitory Effects ◽  
Interacting Protein ◽  
Steady State Inactivation

Kv4/K channel interacting protein (KChIP) potassium channels are a major class of rapidly inactivating K+ channels in neurons and cardiac muscle. Modulation of Kv4/KChIP channels by polyunsaturated fatty acids (PUFAs) is important in the regulation of cellular excitability and the induction of activity-dependent synaptic plasticity. Using the Xenopus laevis oocyte expression system, we studied the inhibition by PUFAs of the peak outward K+ current and the accompanying increase in the rate of current inactivation of rKv4.2/rKChIP1b. Inhibitory effects do not depend on KChIP coexpression since Kv4.2 channels lacking an NH2-terminal KChIP association region were substantially inhibited by PUFAs and showed strong kinetic modulation. PUFAs accelerated both the fast and slow time constants that describe the kinetics of Kv4/KChIP inactivation. The time course of entry into closed inactivated states was facilitated by PUFAs, but steady-state inactivation and recovery from inactivation were unaltered. PUFA inhibition of Kv4/KChIP current was not use dependent. The concentration-response relationship for arachidonic acid (AA) inhibition of Kv4/KChIP channels mimicked that for activation of TRAAK channels. Internal serum albumin largely prevents the inhibitory effects of externally applied AA, and the membrane-impermeant AA-CoA is inactive when applied externally. Overall, our data suggest that PUFAs inhibit Kv4/KChIP channels by facilitating inactivation from open and closed gating states and that access of the fatty acid to the internal leaflet of the membrane is important. These results improve our understanding of the mechanisms for the inhibitory effects of PUFAs on Kv4/KChIP channel function.

Inhibition of the cardiac transient outward K+ channel, Kv1.4, by polyunsaturated fatty acids

2007 ◽  
Vol 42 (6) ◽  
pp. S18
Author(s):  
Noha E. Farag ◽  
Samy Y. Makary ◽  
James O. Tellez ◽  
Tom W. Claydon ◽  
Mark R. Boyett
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
K Channel

scholarly journals Construction of a K Channel Hypersensitive to Polyunsaturated Fatty Acids

2013 ◽  
Vol 104 (2) ◽  
pp. 464a
Author(s):  
Nina Ottosson ◽  
Sara I Liin ◽  
Fredrik Elinder
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
K Channel

A randomized, double-blind, placebo-controlled study of polyunsaturated fatty acids efficacy in adolescents with anorexia nervosa

2020 ◽  
Vol 36 (2) ◽  
pp. 95-106
Author(s):  
Agnieszka M. Piróg-Balcerzak ◽  
Anna K. Bażyńska ◽  
Katarzyna Biernacka ◽  
Joanna Brągoszewska ◽  
Lidia Popek ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Anorexia Nervosa ◽  
Polyunsaturated Fatty Acids ◽  
Small Sample Size ◽  
Small Sample ◽  
Female Adolescent ◽  
Eating Attitude ◽  
Controlled Study ◽  
Omega 3 ◽  
Eat 26

Objective. Omega–3 polyunsaturated fatty acids (PUFAs) were tested in adolescent depression and in several neurodevelopmental disorders with partial success. Anorexia nervosa (AN) is characterised by deficiencies in fatty food intake and frequent comorbidity, including depressive and cognitive symptoms. Thus supplementation with PUFAs may be beneficial in this group of patients. The aim of the study was to assess whether PUFAs as an add-on treatment is associated with better improvement of body mass index (BMI) and psychopathological symptoms than placebo in patients with AN. Method. 61 female adolescent inpatients with AN were randomly allocated to omega–3 PUFAs supplementation or placebo for 10 weeks. Patients also participated in the behavioural programme and eclectic psychotherapy (treatment as usual, TAU). At baseline and follow-up visits, patients’ BMI and psychopathology were assessed with Clinical Global Impression Scale (CGI), Patient Global Impression Scale (PGI), and Eating Attitude Test (EAT-26). Results. After 10 weeks, both groups showed improvement in all parameters. Improvement in CGI scores was observed greater in placebo vs. PUFA-s group (p = 0.015) while other differences were not statistically significant. Omega–3 PUFAs supplementation appears not to be effective as an add-on treatment in inpatient adolescent girls with anorexia nervosa. Conclusions. The results should be analysed with caution due to small sample size and heterogeneity in TAU. As the TAU turned out to be highly effective, additional therapeutic effect of PUFA might not be visible. Nevertheless, that does not explain the tendency for better improvement in the placebo group.

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