scholarly journals Cross-talk between G-protein and Protein Kinase C Modulation of N-type Calcium Channels Is Dependent on the G-protein β Subunit Isoform

2000 ◽  
Vol 275 (52) ◽  
pp. 40777-40781 ◽  
Author(s):  
Conan B. Cooper ◽  
Michelle I. Arnot ◽  
Zhong-Ping Feng ◽  
Scott E. Jarvis ◽  
Jawed Hamid ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Calcium Channels ◽  
G Protein ◽  
Cross Talk ◽  
Β Subunit ◽  
Kinase C

scholarly journals Identification of an Integration Center for Cross-talk between Protein Kinase C and G Protein Modulation of N-type Calcium Channels

1999 ◽  
Vol 274 (10) ◽  
pp. 6195-6202 ◽  
Author(s):  
Jawed Hamid ◽  
Donald Nelson ◽  
Renee Spaetgens ◽  
Stefan J. Dubel ◽  
Terry P. Snutch ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Calcium Channels ◽  
G Protein ◽  
Cross Talk ◽  
Kinase C

scholarly journals A Single Gβ Subunit Locus Controls Cross-talk between Protein Kinase C and G Protein Regulation of N-type Calcium Channels

2004 ◽  
Vol 279 (28) ◽  
pp. 29709-29717 ◽  
Author(s):  
Clinton J. Doering ◽  
Alexandra E. Kisilevsky ◽  
Zhong-Ping Feng ◽  
Michelle I. Arnot ◽  
Jean Peloquin ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Calcium Channels ◽  
G Protein ◽  
Cross Talk ◽  
Protein Regulation ◽  
Kinase C

Expression of myogenic constrictor tone in the aorta of hypertensive rats

2001 ◽  
Vol 280 (4) ◽  
pp. R968-R975 ◽  
Author(s):  
Michelle Rapacon-Baker ◽  
Fan Zhang ◽  
Michael L. Pucci ◽  
Hui Guan ◽  
Alberto Nasjletti
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Calcium Channels ◽  
Thoracic Aorta ◽  
Calcium Influx ◽  
Intraluminal Pressure ◽  
Hypertensive Rats ◽  
Calcium Dependent ◽  
Kinase C ◽  
Basal Tone

We investigated the effect of intraluminal pressure or stretch on the development of tone in the descending thoracic aorta from rats with aortic coarctation-induced hypertension of 7–14 days duration. Increments of pressure >100 mmHg decreased the diameter of thoracic aortas from hypertensive but not from normotensive rats. The pressure-induced constriction was not demonstrable in vessels superfused with calcium-free buffer. Stretched rings of aorta from hypertensive rats exhibited a calcium-dependent constrictor tone accompanied by elevated calcium influx that varied in relation to the degree of stretch. Blockers of l-type calcium channels and inhibitors of protein kinase C reduced both basal tone and calcium influx in aortic rings of hypertensive rats. Hence, the thoracic aorta of hypertensive rats expresses a pressure- and stretch-activated constrictor mechanism that relies on increased calcium influx throughl-type calcium channels via a protein kinase C-regulated pathway. The expression of such a constrictor mechanism is suggestive of acquired myogenic behavior.

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