scholarly journals Concerted all-or-none subunit interactions mediate slow deactivation of humanether-à-go-go-related gene K+channels.

2016 ◽  
Vol 291 (41) ◽  
pp. 21423-21423
Author(s):  
Steven J. Thomson ◽  
Angela Hansen ◽  
Michael C. Sanguinetti
Keyword(s):  
Related Gene ◽  
Subunit Interactions ◽  
K Channels

scholarly journals Concerted All-or-none Subunit Interactions Mediate Slow Deactivation of Humanether-à-go-go-related Gene K+Channels

2014 ◽  
Vol 289 (34) ◽  
pp. 23428-23436 ◽  
Author(s):  
Steven J. Thomson ◽  
Angela Hansen ◽  
Michael C. Sanguinetti
Keyword(s):  
Related Gene ◽  
Subunit Interactions ◽  
K Channels

Modulation of the K+Channels Encoded by the Human Ether-a-Gogo-Related Gene-1 (hERG1) by Nitric Oxide

1999 ◽  
Vol 56 (6) ◽  
pp. 1298-1308 ◽  
Author(s):  
Maurizio Taglialatela ◽  
Anna Pannaccione ◽  
Silvana Iossa ◽  
Pasqualina Castaldo ◽  
Lucio Annunziato
Keyword(s):  
Nitric Oxide ◽  
Related Gene ◽  
K Channels

scholarly journals Kv11 ( ether‐à‐go‐go ‐related gene) voltage‐dependent K + channels promote resonance and oscillation of subthreshold membrane potentials

2020 ◽  
Author(s):  
Toshinori Matsuoka ◽  
Miwako Yamasaki ◽  
Manabu Abe ◽  
Yukiko Matsuda ◽  
Hiroyuki Morino ◽  
...  
Keyword(s):  
Membrane Potentials ◽  
Related Gene ◽  
K Channels ◽  
Voltage Dependent

scholarly journals Cooperative subunit interactions mediate fast C-type inactivation of hERG1 K+channels

2014 ◽  
Vol 592 (20) ◽  
pp. 4465-4480 ◽  
Author(s):  
Wei Wu ◽  
Alison Gardner ◽  
Michael C. Sanguinetti
Keyword(s):  
Subunit Interactions ◽  
K Channels

scholarly journals A pharmacological master key mechanism that unlocks the selectivity filter gate in K+channels

Science ◽  
2019 ◽  
Vol 363 (6429) ◽  
pp. 875-880 ◽  
Author(s):  
Marcus Schewe ◽  
Han Sun ◽  
Ümit Mert ◽  
Alexandra Mackenzie ◽  
Ashley C. W. Pike ◽  
...  
Keyword(s):  
Selectivity Filter ◽  
Rational Drug Design ◽  
Related Gene ◽  
K Channels ◽  
X Ray ◽  
Voltage Gated ◽  
X Ray Crystallography ◽  
Rational Drug ◽  
Dynamics Simulations ◽  
Pore Domain

Potassium (K+) channels have been evolutionarily tuned for activation by diverse biological stimuli, and pharmacological activation is thought to target these specific gating mechanisms. Here we report a class of negatively charged activators (NCAs) that bypass the specific mechanisms but act as master keys to open K+channels gated at their selectivity filter (SF), including many two-pore domain K+(K2P) channels, voltage-gated hERG (human ether-à-go-go–related gene) channels and calcium (Ca2+)–activated big-conductance potassium (BK)–type channels. Functional analysis, x-ray crystallography, and molecular dynamics simulations revealed that the NCAs bind to similar sites below the SF, increase pore and SF K+occupancy, and open the filter gate. These results uncover an unrecognized polypharmacology among K+channel activators and highlight a filter gating machinery that is conserved across different families of K+channels with implications for rational drug design.

scholarly journals Human ether-a-go-go related gene (hERG) K+ channels: Function and dysfunction

2008 ◽  
Vol 98 (2-3) ◽  
pp. 137-148 ◽  
Author(s):  
Mark J. Perrin ◽  
Rajesh N. Subbiah ◽  
Jamie I. Vandenberg ◽  
Adam P. Hill
Keyword(s):  
Related Gene ◽  
K Channels

Human ether-a-go-go-related gene K+channels regulate shedding of leukemia cell-derived microvesicles

2012 ◽  
Vol 53 (8) ◽  
pp. 1592-1598 ◽  
Author(s):  
Fang Zheng ◽  
Juanjuan Li ◽  
Wen Du ◽  
Ningfang Wang ◽  
Huiyu Li ◽  
...  
Keyword(s):  
Leukemia Cell ◽  
Related Gene ◽  
K Channels

Human Ether-a-gogo Related Gene (HERG) K Channels as Pharmacological Targets

1998 ◽  
Vol 55 (11) ◽  
pp. 1741-1746 ◽  
Author(s):  
Maurizio Taglialatela ◽  
Pasqualina Castaldo ◽  
Anna Pannaccione ◽  
Giovanna Giorgio ◽  
Lucio Annunziato
Keyword(s):  
Related Gene ◽  
K Channels ◽  
Pharmacological Targets

scholarly journals Hirsutenone Directly Blocks Human ether-a-go-go Related Gene K+ Channels

2011 ◽  
Vol 34 (12) ◽  
pp. 1815-1822 ◽  
Author(s):  
Jihyun Yun ◽  
Hyemi Bae ◽  
Sun Eun Choi ◽  
Jung-Ha Kim ◽  
Young Wook Choi ◽  
...  
Keyword(s):  
Related Gene ◽  
K Channels
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