scholarly journals Homologous elements hs3a and hs3b in the 3′ regulatory region of the murine immunoglobulin heavy chain (Igh) locus are both dispensable for class-switch recombination.

2012 ◽  
Vol 287 (14) ◽  
pp. 11284-11284
Author(s):  
Yi Yan ◽  
Joyce Pieretti ◽  
Zhongliang Ju ◽  
Shiniu Wei ◽  
John R. Christin ◽  
...  
Keyword(s):  
Heavy Chain ◽  
Regulatory Region ◽  
Class Switch Recombination ◽  
Immunoglobulin Heavy Chain ◽  
Class Switch ◽  
Igh Locus

scholarly journals IgD class switch recombination is not controlled through the immunoglobulin heavy chain 3′ regulatory region super-enhancer

2017 ◽  
Vol 14 (10) ◽  
pp. 871-874 ◽  
Author(s):  
Hussein Issaoui ◽  
Nour Ghazzaui ◽  
Alexis Saintamand ◽  
Yves Denizot ◽  
François Boyer
Keyword(s):  
Heavy Chain ◽  
Regulatory Region ◽  
Class Switch Recombination ◽  
Immunoglobulin Heavy Chain ◽  
Class Switch ◽  
Super Enhancer

HIV-1 nef suppression of B-cell immunoglobulin heavy chain class-switch recombination

2006 ◽  
Vol 6 (5) ◽  
pp. 355-356
Author(s):  
Jamila C. Martin ◽  
Sapandeep K. Singh ◽  
David P. Huston
Keyword(s):  
B Cell ◽  
Heavy Chain ◽  
Class Switch Recombination ◽  
Immunoglobulin Heavy Chain ◽  
Class Switch ◽  
Hiv 1

The immunoglobulin heavy-chain locus hs3b and hs4 3′ enhancers are dispensable for VDJ assembly and somatic hypermutation

Blood ◽  
2003 ◽  
Vol 102 (4) ◽  
pp. 1421-1427 ◽  
Author(s):  
Caroline Le Morvan ◽  
Eric Pinaud ◽  
Catherine Decourt ◽  
Armelle Cuvillier ◽  
Michel Cogné
Keyword(s):  
B Cells ◽  
B Cell ◽  
Heavy Chain ◽  
Somatic Hypermutation ◽  
Class Switch Recombination ◽  
Immunoglobulin Heavy Chain ◽  
Germinal Centers ◽  
Affinity Maturation ◽  
Class Switch ◽  
Endogenous Locus

Abstract The more distal enhancers of the immunoglobulin heavy-chain 3′ regulatory region, hs3b and hs4, were recently demonstrated as master control elements of germline transcription and class switch recombination to most immunoglobulin constant genes. In addition, they were shown to enhance the accumulation of somatic mutations on linked transgenes. Since somatic hypermutation and class switch recombination are tightly linked processes, their common dependency on the endogenous locus 3′ enhancers could be an attractive hypothesis. VDJ structure and somatic hypermutation were analyzed in B cells from mice carrying either a heterozygous or a homozygous deletion of these enhancers. We find that hs3b and hs4 are dispensable both for VDJ assembly and for the occurrence of mutations at a physiologic frequency in the endogenous locus. In addition, we show that cells functionally expressing the immunoglobulin M (IgM) class B-cell receptor encoded by an hs3b/hs4-deficient locus were fully able to enter germinal centers, undergo affinity maturation, and yield specific antibody responses in homozygous mutant mice, where IgG1 antibodies compensated for the defect in other IgG isotypes. By contrast, analysis of Peyer patches from heterozygous animals showed that peanut agglutinin (PNAhigh) B cells functionally expressing the hs3b/hs4-deficient allele were dramatically outclassed by B cells expressing the wild-type locus and normally switching to IgA. This study thus also highlights the role of germinal centers in the competition between B cells for affinity maturation and suggests that membrane IgA may promote recruitment in an activated B-cell compartment, or proliferation of activated B cells, more efficiently than IgM in Peyer patches.

53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination

2004 ◽  
Vol 5 (5) ◽  
pp. 481-487 ◽  
Author(s):  
John P Manis ◽  
Julio C Morales ◽  
Zhenfang Xia ◽  
Jeffery L Kutok ◽  
Frederick W Alt ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Damage Response ◽  
Heavy Chain ◽  
Class Switch Recombination ◽  
Immunoglobulin Heavy Chain ◽  
Class Switch ◽  
Damage Response
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