scholarly journals Ursolic acid, a pentacyclin triterpene, potentiates TRAIL-induced apoptosis through p53-independent up-regulation of death receptors.EVIDENCE FOR THE ROLE OF REACTIVE OXYGEN SPECIES AND JNK.

2016 ◽  
Vol 291 (32) ◽  
pp. 16924-16924 ◽  
Author(s):  
Sahdeo Prasad ◽  
Vivek R. Yadav ◽  
Ramaswamy Kannappan ◽  
Bharat B. Aggarwal
Keyword(s):  
Reactive Oxygen Species ◽  
Ursolic Acid ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Induced Apoptosis

Role of Reactive Oxygen Species and Bcl-2 Family Proteins in TNF-α-Induced Apoptosis of Lymphocytes

2010 ◽  
Vol 149 (2) ◽  
pp. 180-183 ◽  
Author(s):  
N. V. Ryazanceva ◽  
V. V. Novickiy ◽  
O. B. Zhukova ◽  
A. K. Biktasova ◽  
O. E. Chechina ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Tnf Α ◽  
Induced Apoptosis

Role of mitochondrial complexes I and II, reactive oxygen species and arachidonic acid metabolism in deoxycholate-induced apoptosis

2002 ◽  
Vol 177 (2) ◽  
pp. 129-144 ◽  
Author(s):  
Delon Washo-Stultz ◽  
Cara L Crowley-Weber ◽  
Katerina Dvorakova ◽  
Carol Bernstein ◽  
Harris Bernstein ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Arachidonic Acid ◽  
Acid Metabolism ◽  
Reactive Oxygen ◽  
Arachidonic Acid Metabolism ◽  
Oxygen Species ◽  
Mitochondrial Complexes ◽  
Induced Apoptosis

scholarly journals Crucial Role of Reactive Oxygen Species (ROS) for the Proapoptotic Effects of Indirubin Derivatives in Cutaneous SCC Cells

Antioxidants ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 1514
Author(s):  
Jiaqi Zhu ◽  
Peter Langer ◽  
Claas Ulrich ◽  
Jürgen Eberle
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Proliferation ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Antitumor Effects ◽  
Apoptosis Protein ◽  
High Incidence ◽  
Induced Apoptosis ◽  
Transcription 3

Efficient drugs are needed for countering the worldwide high incidence of cutaneous squamous cell carcinoma (cSCC) and actinic keratosis. Indirubin derivatives represent promising candidates, but their effects in cSCC cells have not been reported before. Here, we investigated the efficacy of three indirubin derivatives (DKP-071, -073 and -184) in four cSCC cell lines. High efficacy was seen in SCL-I, SCL-II, SCC-12 and SCC-13, resulting in up to 80% loss of cell proliferation, 60% loss of cell viability and 30% induced apoptosis (10 µM). Apoptosis was further enhanced in combinations with TNF-related apoptosis-inducing ligand (TRAIL). Induction of reactive oxygen species (ROS) appeared as critical for these effects. Thus, antioxidative pretreatment completely abolished apoptosis as well as restored cell proliferation and viability. Concerning the pathways, complete activation of caspases cascades (caspases-3, -4, -6, -7, -8 and -9), loss of mitochondrial membrane potential, activation of proapoptotic PKCδ (protein kinase C delta), inhibition of STAT3 (signal transducer and activator of transcription 3), downregulation of antiapoptotic XIAP (X-linked inhibitor of apoptosis protein) and survivin as well as upregulation of the proapoptotic Bcl-2 protein Puma and the cell cycle inhibitor p21 were obtained. Importantly, all activation steps were prevented by antioxidants, thus proving ROS as a master regulator of indirubins’ antitumor effects. ROS induction presently develops as an important issue in anticancer therapy.

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