Sustained Activation of the Extracellular Signal-regulated Kinase/Mitogen-activated Protein Kinase Pathway Is Required for Megakaryocytic Differentiation of K562 Cells

Frederick K. Racke; Kristine Lewandowska; Said Goueli; Adam N. Goldfarb

doi:10.1074/jbc.272.37.23366

Sustained Activation of the Extracellular Signal-regulated Kinase/Mitogen-activated Protein Kinase Pathway Is Required for Megakaryocytic Differentiation of K562 Cells

Journal of Biological Chemistry ◽

10.1074/jbc.272.37.23366 ◽

1997 ◽

Vol 272 (37) ◽

pp. 23366-23370 ◽

Cited By ~ 133

Author(s):

Frederick K. Racke ◽

Kristine Lewandowska ◽

Said Goueli ◽

Adam N. Goldfarb

Keyword(s):

Protein Kinase ◽

K562 Cells ◽

Mitogen Activated Protein Kinase ◽

Megakaryocytic Differentiation ◽

Extracellular Signal Regulated Kinase ◽

Extracellular Signal ◽

Mitogen Activated Protein ◽

Kinase Pathway ◽

Sustained Activation

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Plasma leptin concentrations are greater in type II diabetic patients and stimulate monocyte chemotactic peptide-1 synthesis via the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway

Kidney Research and Clinical Practice ◽

10.1016/j.krcp.2012.06.004 ◽

2012 ◽

Vol 31 (3) ◽

pp. 177-185 ◽

Cited By ~ 3

Author(s):

Jin Joo Cha ◽

Young Youl Hyun ◽

Yi Hwa Jee ◽

Mi Jin Lee ◽

Kum Hyun Han ◽

...

Keyword(s):

Protein Kinase ◽

Mitogen Activated Protein Kinase ◽

Diabetic Patients ◽

Type Ii ◽

Chemotactic Peptide ◽

Extracellular Signal Regulated Kinase ◽

Extracellular Signal ◽

Mitogen Activated Protein ◽

Plasma Leptin ◽

Kinase Pathway

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The Cooked Meat Carcinogen 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine Activates the Extracellular Signal–Regulated Kinase Mitogen-Activated Protein Kinase Pathway

Cancer Research ◽

10.1158/0008-5472.can-07-2821 ◽

2007 ◽

Vol 67 (23) ◽

pp. 11455-11462 ◽

Cited By ~ 20

Author(s):

Stuart K. Creton ◽

Huijun Zhu ◽

Nigel J. Gooderham

Keyword(s):

Protein Kinase ◽

Mitogen Activated Protein Kinase ◽

Extracellular Signal Regulated Kinase ◽

Extracellular Signal ◽

Mitogen Activated Protein ◽

Cooked Meat ◽

Kinase Pathway

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Different Effects of Amlodipine and Enalapril on the Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase-Extracellular Signal-Regulated Kinase Pathway for Induction of Vascular Smooth Muscle Cell Differentiation In Vivo

Hypertension Research ◽

10.1291/hypres.29.179 ◽

2006 ◽

Vol 29 (3) ◽

pp. 179-186 ◽

Cited By ~ 16

Author(s):

Seiji UMEMOTO ◽

Shinji KAWAHARA ◽

Ryo HASHIMOTO ◽

Kyoko UMEJI ◽

Susumu MATSUDA ◽

...

Keyword(s):

Smooth Muscle ◽

Protein Kinase ◽

Mitogen Activated Protein Kinase ◽

Extracellular Signal Regulated Kinase ◽

Muscle Cell Differentiation ◽

Smooth Muscle Cell Differentiation ◽

Extracellular Signal ◽

Mitogen Activated Protein ◽

Kinase Pathway

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Regulation of enhanced cerebrovascular expression of proinflammatory mediators in experimental subarachnoid hemorrhage via the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathway

Journal of Neuroinflammation ◽

10.1186/1742-2094-9-274 ◽

2012 ◽

Vol 9 (1) ◽

Cited By ~ 37

Author(s):

Aida Maddahi ◽

Gro Povlsen ◽

Lars Edvinsson

Keyword(s):

Subarachnoid Hemorrhage ◽

Protein Kinase ◽

Mitogen Activated Protein Kinase ◽

Extracellular Signal Regulated Kinase ◽

Proinflammatory Mediators ◽

Extracellular Signal ◽

Mitogen Activated Protein ◽

Experimental Subarachnoid Hemorrhage ◽

Kinase Pathway ◽

Protein Kinase Kinase

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Trop2 inhibition suppresses the proliferation and invasion of laryngeal carcinoma cells via the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway

Molecular Medicine Reports ◽

10.3892/mmr.2015.3485 ◽

2015 ◽

Vol 12 (1) ◽

pp. 865-870 ◽

Cited By ~ 7

Author(s):

XU-DONG WANG ◽

QIANG WANG ◽

XIAO-LIN CHEN ◽

JIAN-FEI HUANG ◽

YONG YIN ◽

...

Keyword(s):

Protein Kinase ◽

Laryngeal Carcinoma ◽

Carcinoma Cells ◽

Mitogen Activated Protein Kinase ◽

Extracellular Signal Regulated Kinase ◽

Extracellular Signal ◽

Mitogen Activated Protein ◽

Kinase Pathway ◽

Proliferation And Invasion

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Quercetin enhances adriamycin cytotoxicity through induction of apoptosis and regulation of mitogen-activated protein kinase/extracellular signal-regulated kinase/c-Jun N-terminal kinase signaling in multidrug-resistant leukemia K562 cells

Molecular Medicine Reports ◽

10.3892/mmr.2014.2734 ◽

2014 ◽

Vol 11 (1) ◽

pp. 341-348 ◽

Cited By ~ 20

Author(s):

FANG-YUAN CHEN ◽

LAN-FANG CAO ◽

HAI-XIA WAN ◽

MIN-YUE ZHANG ◽

JIA-YI CAI ◽

...

Keyword(s):

Protein Kinase ◽

K562 Cells ◽

Multidrug Resistant ◽

Mitogen Activated Protein Kinase ◽

Kinase Signaling ◽

Extracellular Signal Regulated Kinase ◽

Kinase C ◽

Extracellular Signal ◽

Mitogen Activated Protein ◽

Induction Of Apoptosis

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Inhibition of the Extracellular Signal-regulated Kinase/Mitogen-activated Protein Kinase Pathway Decreases DNA Methylation in Colon Cancer Cells

Journal of Biological Chemistry ◽

10.1074/jbc.m608525200 ◽

2007 ◽

Vol 282 (16) ◽

pp. 12249-12259 ◽

Cited By ~ 75

Author(s):

Rong Lu ◽

Xia Wang ◽

Zhao-Fei Chen ◽

Dan-Feng Sun ◽

Xiao-Qing Tian ◽

...

Keyword(s):

Dna Methylation ◽

Colon Cancer ◽

Protein Kinase ◽

Cancer Cells ◽

Mitogen Activated Protein Kinase ◽

Colon Cancer Cells ◽

Extracellular Signal Regulated Kinase ◽

Extracellular Signal ◽

Mitogen Activated Protein ◽

Kinase Pathway

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Regulation of expression ofABCB1andLRPgenes by mitogen-activated protein kinase/extracellular signal-regulated kinase pathway and its role in generation of side population cells in canine lymphoma cell lines

Leukemia & Lymphoma ◽

10.3109/10428194.2012.751529 ◽

2012 ◽

Vol 54 (6) ◽

pp. 1309-1315 ◽

Cited By ~ 14

Author(s):

Hirotaka Tomiyasu ◽

Manabu Watanabe ◽

Yuko Goto-Koshino ◽

Yasuhito Fujino ◽

Koichi Ohno ◽

...

Keyword(s):

Protein Kinase ◽

Side Population ◽

Mitogen Activated Protein Kinase ◽

Side Population Cells ◽

Regulation Of Expression ◽

Canine Lymphoma ◽

Extracellular Signal Regulated Kinase ◽

Extracellular Signal ◽

Mitogen Activated Protein ◽

Kinase Pathway

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Editor's Note: p38 Mitogen-activated Protein Kinase Pathway Suppresses Cell Survival by Inducing Dephosphorylation of Mitogen-activated Protein/Extracellular Signal-regulated Kinase Kinase1,2

Cancer Research ◽

10.1158/0008-5472.can-19-3320 ◽

2020 ◽

Vol 80 (2) ◽

pp. 364-364 ◽

Cited By ~ 3

Author(s):

Song-Ping Li ◽

Melissa R. Junttila ◽

Jiahuai Han ◽

Veli-Matti Kähäri ◽

Jukka Westermarck

Keyword(s):

Protein Kinase ◽

Cell Survival ◽

Mitogen Activated Protein Kinase ◽

Extracellular Signal Regulated Kinase ◽

Extracellular Signal ◽

Mitogen Activated Protein ◽

Kinase Pathway

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Dual-specificity Phosphatase 1 Deficiency Induces Endometrioid Adenocarcinoma Progression via Activation of Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Pathway

Chinese Medical Journal ◽

10.4103/0366-6999.181954 ◽

2016 ◽

Vol 129 (10) ◽

pp. 1154-1160 ◽

Cited By ~ 6

Author(s):

Yuan Yang ◽

Jing-Yi Zhou ◽

Li-Jun Zhao ◽

Bao-Rong Gao ◽

Xiao-Ping Wan ◽

...

Keyword(s):

Protein Kinase ◽

Mitogen Activated Protein Kinase ◽

Endometrioid Adenocarcinoma ◽

Dual Specificity Phosphatase ◽

Extracellular Signal Regulated Kinase ◽

Dual Specificity ◽

Extracellular Signal ◽

Mitogen Activated Protein ◽

Kinase Pathway

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