scholarly journals Regulation of Tissue-specific Expression of the Skeletal Muscle Ryanodine Receptor Gene

1996 ◽  
Vol 271 (9) ◽  
pp. 4763-4769 ◽  
Author(s):  
Sabine Schmoelzl ◽  
Tosso Leeb ◽  
Heinrich Brinkmeier ◽  
Gottfried Brem ◽  
Bertram Brenig
Keyword(s):  
Skeletal Muscle ◽  
Ryanodine Receptor ◽  
Receptor Gene ◽  
Specific Expression ◽  
Tissue Specific ◽  
Tissue Specific Expression

scholarly journals The murine NPY-1 receptor gene Structure and delineation of tissue-specific expression

FEBS Letters ◽  
1992 ◽  
Vol 314 (3) ◽  
pp. 285-288 ◽  
Author(s):  
Carola Eva ◽  
Alessandra Oberto ◽  
Rolf Sprengel ◽  
Enrico Genazzani
Keyword(s):  
Gene Structure ◽  
Receptor Gene ◽  
Specific Expression ◽  
Tissue Specific ◽  
Tissue Specific Expression

scholarly journals Post-Mortem Stability of RNA in Skeletal Muscle and Adipose Tissue and the Tissue-Specific Expression of Myostatin, Perilipin and Associated Factors in the Horse

PLoS ONE ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. e100810 ◽  
Author(s):  
Philippa K. Morrison ◽  
Chen Bing ◽  
Patricia A. Harris ◽  
Charlotte A. Maltin ◽  
Dai Grove-White ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Adipose Tissue ◽  
Associated Factors ◽  
Post Mortem ◽  
Specific Expression ◽  
Tissue Specific ◽  
Tissue Specific Expression

scholarly journals Transgenic Mice Demonstrate Novel Promoter Regions for Tissue-Specific Expression of the Urokinase Receptor Gene

2003 ◽  
Vol 163 (2) ◽  
pp. 453-464 ◽  
Author(s):  
Heng Wang ◽  
John Hicks ◽  
Parham Khanbolooki ◽  
Sun-Jin Kim ◽  
Chunhong Yan ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Receptor Gene ◽  
Urokinase Receptor ◽  
Promoter Regions ◽  
Specific Expression ◽  
Tissue Specific ◽  
Tissue Specific Expression

scholarly journals Comprehensive analysis of lncRNAs involved in skeletal muscle development in ZBED6-knockout Bama pigs

BMC Genomics ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Dandan Wang ◽  
Yabin Pu ◽  
Yefang Li ◽  
Dengke Pan ◽  
Shengnan Wang ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Mass ◽  
Muscle Development ◽  
Longissimus Dorsi ◽  
Skeletal Muscle Development ◽  
Mass Model ◽  
Specific Expression ◽  
Tissue Specific ◽  
Tissue Specific Expression ◽  
New Research

Abstract Background The mutation of insulin-like growth factor 2 (IGF2 mutation) that a single-nucleotide substitution (G→A) in the third intron of IGF2 abrogates the interaction with zinc finger BED-type containing 6 (ZBED6) and leads to increased muscle mass in pigs. IGF2 mutation knock-in (IGF2 KI) and ZBED6 knockout (ZBED6 KO) lead to changes in IGF2 expression and increase muscle mass in mice and pigs. Long noncoding RNAs (lncRNAs) may participate in numerous biological processes, including skeletal muscle development. However, the role of the ZBED6-lncRNA axis in skeletal muscle development is poorly characterized. Results In this study, we assembled transcriptomes using RNA-seq data published in previous studies by our group and identified 11,408 known lncRNAs and 2269 potential lncRNAs in seven tissues, heart, longissimus dorsi, gastrocnemius muscle, liver, spleen, lung and kidney, of ZBED6 KO (lean mass model) and WT Bama pigs. ZBED6 affected the expression of 1570 lncRNAs (differentially expressed lncRNAs [DE-lncRNAs]; log2-fold change ≥ 1, nominal p-value ≤ 0.05) in the seven examined tissues. The expressed lncRNAs (FPKM > 0.1) exhibited tissue-specific patterns in WT pigs. Specifically, 3410 lncRNAs were expressed exclusively in only one tissue. Potential functions of lncRNAs were indirectly predicted by searching their target cis- and trans-regulated protein-coding genes. LncRNAs with tissue-specific expression influence numerous genes related to tissue functions. Weighted gene coexpression network analysis (WGCNA) of 1570 DE-lncRNAs between WT and ZBED6 KO pigs was used to define the following six lncRNA modules specific to different tissues: skeletal muscle, heart, lung, spleen, kidney and liver modules. Furthermore, by conjoint analysis of longissimus dorsi data (tissue-specific expression, muscle module and DE-lncRNAs) and ChIP-PCR revealed NONSUSG002145.1 (adjusted p-values = 0.044), which is coexpressed with the IGF2 gene and binding with ZBED6, may play important roles in ZBED6 KO pig skeletal muscle development. Conclusions These findings indicate that the identified lncRNAs may play essential roles in tissue function and regulate the mechanism of ZBED6 action in skeletal muscle development in pigs. To our knowledge, this is the first study describing lncRNAs in ZBED6 KO pigs. These results may open new research directions leading to a better understanding of the global functions of ZBED6 and of lncRNA functions in skeletal muscle development in pigs.

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