scholarly journals The Influence of Sphingomyelin on the Structure and Function of Reconstituted High Density Lipoproteins

1996 ◽  
Vol 271 (8) ◽  
pp. 4243-4250 ◽  
Author(s):  
Kerry-Anne Rye ◽  
Neil J. Hime ◽  
Philip J. Barter
Keyword(s):  
Structure And Function ◽  
High Density ◽  
High Density Lipoproteins ◽  
And Function

scholarly journals High-density lipoproteins for therapeutic delivery systems

2016 ◽  
Vol 4 (2) ◽  
pp. 188-197 ◽  
Author(s):  
R. Kannan Mutharasan ◽  
Linda Foit ◽  
C. Shad Thaxton
Keyword(s):  
Drug Delivery ◽  
Delivery Systems ◽  
Structure And Function ◽  
High Density ◽  
High Density Lipoproteins ◽  
Delivery Vehicle ◽  
Drug Delivery Vehicle ◽  
Therapeutic Delivery ◽  
And Function

High-density lipoproteins are a class of natural nanostructures with multiple desirable properties to model in a drug delivery vehicle. Here we review the structure and function of high-density lipoproteins, and their use as therapeutic delivery systems.

scholarly journals The Structure and Function of Serum Opacity Factor: A Unique Streptococcal Virulence Determinant That Targets High-Density Lipoproteins

2010 ◽  
Vol 2010 ◽  
pp. 1-16 ◽  
Author(s):  
Harry S. Courtney ◽  
Henry J. Pownall
Keyword(s):  
Lipid Vesicles ◽  
Structure And Function ◽  
High Density ◽  
Host Cells ◽  
High Density Lipoproteins ◽  
Multifunctional Protein ◽  
Virulence Determinant ◽  
Serum Opacity Factor ◽  
Animal Pathogens ◽  
And Function

Serum opacity factor (SOF) is a virulence determinant expressed by a variety of streptococcal and staphylococcal species including both human and animal pathogens. SOF derives its name from its ability to opacify serum where it targets and disrupts the structure of high-density lipoproteins resulting in formation of large lipid vesicles that cause the serum to become cloudy. SOF is a multifunctional protein and in addition to its opacification activity, it binds to a number of host proteins that mediate adhesion of streptococci to host cells, and it plays a role in resistance to phagocytosis in human blood. This article will provide an overview of the structure and function of SOF, its role in the pathogenesis of streptococcal infections, its vaccine potential, its prevalence and distribution in bacteria, and the molecular mechanism whereby SOF opacifies serum and how an understanding of this mechanism may lead to therapies for reducing high-cholesterol concentrations in blood, a major risk factor for cardiovascular disease.

scholarly journals Effect of acylglyceride content on the structure and function of reconstituted high density lipoprotein particles

2001 ◽  
Vol 42 (1) ◽  
pp. 79-87 ◽  
Author(s):  
Sylvie Braschi ◽  
Cynthia R. Coffill ◽  
Tracey A-M. Neville ◽  
Darren M. Hutt ◽  
Daniel L. Sparks
Keyword(s):  
High Density Lipoprotein ◽  
Density Lipoprotein ◽  
Structure And Function ◽  
High Density ◽  
Lipoprotein Particles ◽  
And Function

Lipoprotein composition in NIDDM: effects of dietary oleic acid on the composition, oxidisability and function of low and high density lipoproteins

Diabetologia ◽  
1996 ◽  
Vol 39 (6) ◽  
pp. 667-676 ◽  
Author(s):  
E. Dimitriadis ◽  
M. Griffin ◽  
P. Collins ◽  
A. Johnson ◽  
D. Owens ◽  
...  
Keyword(s):  
Oleic Acid ◽  
High Density ◽  
High Density Lipoproteins ◽  
Lipoprotein Composition ◽  
And Function

Dysfunctional high-density lipoprotein: the role of myeloperoxidase and paraoxonase-1

2020 ◽  
Vol 27 ◽  
Author(s):  
Tiziana Bacchetti ◽  
Gianna Ferretti ◽  
Federico Carbone ◽  
Stefano Ministrini ◽  
Fabrizio Montecucco ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Protective Factor ◽  
Density Lipoprotein ◽  
High Density ◽  
Paraoxonase 1 ◽  
High Density Lipoproteins ◽  
Atherosclerotic Cardiovascular Disease ◽  
Potential Marker ◽  
And Function

: Low circulating high-density lipoproteins (HDL) are not only a defining criteria for metabolic syndrome, but are more generally associated with atherosclerotic cardiovascular disease (ASCVD) and other chronic diseases. Oxidative stress, a hallmark of cardio-metabolic disease, further influences HDL activity by suppressing their function. Especially the leukocyte-derived enzyme myeloperoxidase (MPO) has recently attracted great interest as it catalyzes the formation of oxidizing reactive species that modify the structure and function of HDL, ultimately increasing cardiovascular risk. Contrariwise, paraoxonase-1 (PON1) is an HDL-associated enzyme that protects HDL from lipid oxidation, and then acts as a protective factor against ASCVD. Noteworthy, recent studies have demonstrated how MPO, PON1 and HDL form a functional complex in which PON1 partially inhibits the MPO activity, while MPO in turn partially inactivates PON1.In line with that, high MPO/PON1 ratio characterizes patients with ASCVD and metabolic syndrome and has been suggested as a potential marker of dysfunctional HDL as well as a predictor of ASCVD. In this review, we summarize the evidence on the interactions between MPO and PON1 with regard to their structure, function and interaction with HDL activity. We also provide an overview on in vitro and experimental animal models, finally focusing on clinical evidence from cohort of patients with ASCVD and metabolic syndrome.

Lipoprotein composition in NIDDM: effects of dietary oleic acid on the composition, oxidisability and function of low and high density lipoproteins

Diabetologia ◽  
1996 ◽  
Vol 39 (6) ◽  
pp. 667-676 ◽  
Author(s):  
E. Dimitriadis ◽  
M. Griffin ◽  
P. Collins ◽  
A. Johnson ◽  
D. Owens ◽  
...  
Keyword(s):  
Oleic Acid ◽  
High Density ◽  
High Density Lipoproteins ◽  
Lipoprotein Composition ◽  
And Function

High-density lipoproteins (HDL) composition and function in preeclampsia

2018 ◽  
Vol 298 (2) ◽  
pp. 405-413 ◽  
Author(s):  
Yael Einbinder ◽  
Tal Biron-Shental ◽  
Moran Agassi-Zaitler ◽  
Keren Tzadikevitch-Geffen ◽  
Jacob Vaya ◽  
...  
Keyword(s):  
High Density ◽  
High Density Lipoproteins ◽  
And Function

Structure and function of apolipoprotein A-I and high-density lipoprotein

2000 ◽  
Vol 11 (2) ◽  
pp. 105-115 ◽  
Author(s):  
Jere P. Segrest ◽  
Ling Li ◽  
G. M. Anantharamaiah ◽  
Stephen C. Harvey ◽  
Kalliopi N. Liadaki ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
Density Lipoprotein ◽  
Structure And Function ◽  
High Density ◽  
Apolipoprotein A ◽  
And Function
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