scholarly journals Mapping and Functional Role of Phosphorylation Sites in the Thyroid Transcription Factor-1 (TTF-1)

1996 ◽  
Vol 271 (4) ◽  
pp. 2249-2254 ◽  
Author(s):  
Mariastella Zannini ◽  
Alvaro Acebron ◽  
Mario De Felice ◽  
Maria Ina Arnone ◽  
Jorge Martin-Pérez ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Functional Role ◽  
Phosphorylation Sites ◽  
Thyroid Transcription Factor 1 ◽  
Thyroid Transcription Factor ◽  
Transcription Factor 1

An integrative transcriptome analysis reveals a functional role for thyroid transcription factor-1 in small cell lung cancer

2018 ◽  
Vol 246 (2) ◽  
pp. 154-165 ◽  
Author(s):  
Masafumi Horie ◽  
Naoya Miyashita ◽  
Johanna Sofia Margareta Mattsson ◽  
Yu Mikami ◽  
Martin Sandelin ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Transcription Factor ◽  
Small Cell Lung Cancer ◽  
Transcriptome Analysis ◽  
Functional Role ◽  
Small Cell ◽  
Small Cell Lung ◽  
Thyroid Transcription Factor 1 ◽  
Thyroid Transcription Factor ◽  
Transcription Factor 1

Role of thyroid transcription factor-1 in the diagnosis of feline lung–digit syndrome

2016 ◽  
Vol 19 (4) ◽  
pp. 477-483 ◽  
Author(s):  
Riccardo Finotello ◽  
Carlo Masserdotti ◽  
Gianna Baroni ◽  
Lorenzo Ressel
Keyword(s):  
Transcription Factor ◽  
Control Group ◽  
Study Group ◽  
Ciliated Epithelium ◽  
Neoplastic Tissue ◽  
Thyroid Transcription Factor 1 ◽  
Thyroid Transcription Factor ◽  
Formalin Fixed Paraffin Embedded ◽  
Transcription Factor 1

Objectives The aim of this study was to investigate the role of thyroid transcription factor-1 (TTF-1) in the diagnosis of feline lung–digit syndrome (FLDS) and to investigate the associations between the morphological features of FLDS and TTF-1 expression. We also compared the reliability of TTF-1 and transmission electron microscopy (TEM) in establishing the diagnosis of FLDS. Methods Histology records of feline digit tumours were retrieved, including patients from 2008–2015. If formalin-fixed, paraffin-embedded tissues were available for review, patients were included in the study. As a control group we included 12 feline primary tumours of the digits. All the histological slides of the study group were blindly reviewed by the same veterinary pathologist. Representative sections of the lesions were selected for immunohistochemistry (IHC) analysis. To confirm the respiratory origin of the neoplastic tissue, TEM was used as a gold standard in all cases. Results Five cases of FLDS were included. TTF-1 was weakly to moderately positive in 60% of the cases, showing no correlation with the microscopic presence of ciliated epithelium. When IHC results were combined with the presence of cilia, 80% of the cases from the study group could be identified as FLDS. TEM confirmed the presence of ciliated epithelium in all five cases, confirming the respiratory origin of the neoplastic tissue and therefore the diagnosis of FLDS. Conclusions and relevance TTF-1 expression is maintained in FLDS. While the combination of TTF-1 and identification of cilia confirms FLDS, TEM should be considered in those cases where diagnosis is uncertain and FLDS is suspected.

Role of Insulin and Serum on Thyrotropin Regulation of Thyroid Transcription Factor-1 and Pax-8 Genes Expression in FRTL-5 Thyroid Cells

Thyroid ◽  
2000 ◽  
Vol 10 (4) ◽  
pp. 295-303 ◽  
Author(s):  
Diego L. Medina ◽  
Koichi Suzuki ◽  
Michele Pietrarelli ◽  
Fumi Okajima ◽  
Leonard D. Kohn ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Thyroid Cells ◽  
Thyroid Transcription Factor 1 ◽  
Thyroid Transcription Factor ◽  
Genes Expression ◽  
Transcription Factor 1

scholarly journals The prognostic role of thyroid transcription factor-1 in lung adenocarcinoma

2020 ◽  
Vol 16 (4) ◽  
pp. 737 ◽  
Author(s):  
Esin Oktay ◽  
Utku Oflazoglu ◽  
Yelda Varol ◽  
Ozgur Tanriverdi ◽  
Necla Mermur ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Lung Adenocarcinoma ◽  
Prognostic Role ◽  
Thyroid Transcription Factor 1 ◽  
Thyroid Transcription Factor ◽  
Transcription Factor 1
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