scholarly journals Synergistic Transcriptional Activation of the Tissue Inhibitor of Metalloproteinases-1 Promoter via Functional Interaction of AP-1 and Ets-1 Transcription Factors

1996 ◽  
Vol 271 (2) ◽  
pp. 774-782 ◽  
Author(s):  
Susan K. Logan ◽  
Michael J. Garabedian ◽  
Christine E. Campbell ◽  
Zena Werb
Keyword(s):  
Transcription Factors ◽  
Transcriptional Activation ◽  
Tissue Inhibitor Of Metalloproteinases ◽  
Functional Interaction ◽  
Tissue Inhibitor

scholarly journals dCas9-mediated transcriptional activation of tissue inhibitor of metalloproteinases

2017 ◽  
Vol Volume 4 ◽  
pp. 63-73 ◽  
Author(s):  
Tyler Duellman ◽  
Andrea Doll ◽  
Xi Chen ◽  
Rie Wakamiya ◽  
Jay Yang
Keyword(s):  
Transcriptional Activation ◽  
Tissue Inhibitor Of Metalloproteinases ◽  
Tissue Inhibitor

Subnuclear compartmentalization of sequence-specific transcription factors and regulation of eukaryotic gene expression

2005 ◽  
Vol 83 (4) ◽  
pp. 535-547 ◽  
Author(s):  
Gareth N Corry ◽  
D Alan Underhill
Keyword(s):  
Gene Expression ◽  
Transcription Factor ◽  
Transcription Factors ◽  
Transcriptional Activation ◽  
Current Knowledge ◽  
Nuclear Architecture ◽  
Subnuclear Localization ◽  
Modular Structures

To date, the majority of the research regarding eukaryotic transcription factors has focused on characterizing their function primarily through in vitro methods. These studies have revealed that transcription factors are essentially modular structures, containing separate regions that participate in such activities as DNA binding, protein–protein interaction, and transcriptional activation or repression. To fully comprehend the behavior of a given transcription factor, however, these domains must be analyzed in the context of the entire protein, and in certain cases the context of a multiprotein complex. Furthermore, it must be appreciated that transcription factors function in the nucleus, where they must contend with a variety of factors, including the nuclear architecture, chromatin domains, chromosome territories, and cell-cycle-associated processes. Recent examinations of transcription factors in the nucleus have clarified the behavior of these proteins in vivo and have increased our understanding of how gene expression is regulated in eukaryotes. Here, we review the current knowledge regarding sequence-specific transcription factor compartmentalization within the nucleus and discuss its impact on the regulation of such processes as activation or repression of gene expression and interaction with coregulatory factors.Key words: transcription, subnuclear localization, chromatin, gene expression, nuclear architecture.

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