scholarly journals Characterization of the G Protein-coupled Receptor Kinase GRK4

1996 ◽  
Vol 271 (11) ◽  
pp. 6403-6410 ◽  
Author(s):  
Richard T. Premont ◽  
Alexander D. Macrae ◽  
Robert H. Stoffel ◽  
Namjin Chung ◽  
Julie A. Pitcher ◽  
...  
Keyword(s):  
G Protein ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals Characterization of a hyperphosphorylated variant of G protein-coupled receptor kinase 5 expressed in E. coli

2020 ◽  
Vol 168 ◽  
pp. 105547
Author(s):  
Tyler S. Beyett ◽  
Qiuyan Chen ◽  
Emily J. Labudde ◽  
Joseph Krampen ◽  
Prateek V. Sharma ◽  
...  
Keyword(s):  
G Protein ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
E Coli ◽  
G Protein Coupled

Characterization of the carboxyl terminal-truncated endothelin B receptor coexpressed with G protein-coupled receptor kinase 2

IUBMB Life ◽  
1999 ◽  
Vol 47 (4) ◽  
pp. 569-577
Author(s):  
Tadao Shibasaki ◽  
Kayoko Moroi ◽  
Mariko Nishiyama ◽  
Jing Zhou ◽  
Sadao Kimura ◽  
...  
Keyword(s):  
G Protein ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
Endothelin B Receptor ◽  
Carboxyl Terminal ◽  
Endothelin B ◽  
G Protein Coupled

scholarly journals Identification and Characterization of Amlexanox as a G Protein-Coupled Receptor Kinase 5 Inhibitor

Molecules ◽  
2014 ◽  
Vol 19 (10) ◽  
pp. 16937-16949 ◽  
Author(s):  
Kristoff Homan ◽  
Emily Wu ◽  
Alessandro Cannavo ◽  
Walter Koch ◽  
John Tesmer
Keyword(s):  
G Protein ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled ◽  
Identification And Characterization

scholarly journals Historical Perspective of the G Protein-Coupled Receptor Kinase Family

Cells ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 555
Author(s):  
Jeffrey L. Benovic
Keyword(s):  
G Protein ◽  
Historical Perspective ◽  
Heterotrimeric G Proteins ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
The Family ◽  
Primary Focus ◽  
And Function ◽  
G Protein Coupled

Agonist activation of G protein-coupled receptors promotes sequential interaction of the receptor with heterotrimeric G proteins, G protein-coupled receptor kinases (GRKs), and arrestins. GRKs play a central role in mediating the switch from G protein to arrestin interaction and thereby control processes such as receptor desensitization and trafficking and arrestin-mediated signaling. In this review, I provide a historical perspective on some of the early studies that identified the family of GRKs with a primary focus on the non-visual GRKs. These studies included identification, purification, and cloning of the β-adrenergic receptor kinase in the mid- to late-1980s and subsequent cloning and characterization of additional members of the GRK family. This helped to lay the groundwork for ensuing work focused on understanding the structure and function of these important enzymes.

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