scholarly journals A method for detecting abasic sites in living cells: Age-dependent changes in base excision repair

2000 ◽  
Vol 97 (2) ◽  
pp. 686-691 ◽  
Author(s):  
H. Atamna ◽  
I. Cheung ◽  
B. N. Ames
Keyword(s):  
Base Excision Repair ◽  
Excision Repair ◽  
Living Cells ◽  
Abasic Sites ◽  
Age Dependent ◽  
Base Excision

scholarly journals Base excision repair causes age-dependent accumulation of single-stranded DNA breaks that contribute to Parkinson disease pathology

Cell Reports ◽  
2021 ◽  
Vol 36 (10) ◽  
pp. 109668
Author(s):  
Tanima SenGupta ◽  
Konstantinos Palikaras ◽  
Ying Q. Esbensen ◽  
Georgios Konstantinidis ◽  
Francisco Jose Naranjo Galindo ◽  
...  
Keyword(s):  
Parkinson Disease ◽  
Base Excision Repair ◽  
Excision Repair ◽  
Dna Breaks ◽  
Single Stranded Dna ◽  
Age Dependent ◽  
Base Excision

Processing of the abasic sites clustered with the benzo[a]pyrene adducts by the base excision repair enzymes

DNA Repair ◽  
2017 ◽  
Vol 50 ◽  
pp. 43-53 ◽  
Author(s):  
Lidia V. Starostenko ◽  
Nadejda I. Rechkunova ◽  
Natalia A. Lebedeva ◽  
Alexander A. Lomzov ◽  
Vladimir V. Koval ◽  
...  
Keyword(s):  
Base Excision Repair ◽  
Excision Repair ◽  
Abasic Sites ◽  
Repair Enzymes ◽  
Base Excision

scholarly journals A versatile new tool to quantify abasic sites in DNA and inhibit base excision repair

DNA Repair ◽  
2015 ◽  
Vol 27 ◽  
pp. 9-18 ◽  
Author(s):  
Shanqiao Wei ◽  
Sophia Shalhout ◽  
Young-Hoon Ahn ◽  
Ashok S. Bhagwat
Keyword(s):  
Base Excision Repair ◽  
Excision Repair ◽  
Abasic Sites ◽  
Base Excision

Base excision repair-inspired DNA motor powered by intracellular apurinic/apyrimidinic endonuclease

Nanoscale ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 1343-1350 ◽  
Author(s):  
Lidan Li ◽  
Na Li ◽  
Shengnan Fu ◽  
Yingnan Deng ◽  
Changyuan Yu ◽  
...  
Keyword(s):  
Base Excision Repair ◽  
Excision Repair ◽  
Living Cells ◽  
Ap Endonuclease ◽  
Base Excision

A DNA motor was operated in living cells by endogenous AP endonuclease.

scholarly journals Imbalanced Base Excision Repair Increases Spontaneous Mutation and Alkylation Sensitivity inEscherichia coli

1999 ◽  
Vol 181 (21) ◽  
pp. 6763-6771 ◽  
Author(s):  
Lauren M. Posnick ◽  
Leona D. Samson
Keyword(s):  
Base Excision Repair ◽  
Mammalian Cells ◽  
Excision Repair ◽  
Spontaneous Mutation ◽  
Dna Lesions ◽  
Dna Glycosylases ◽  
E Coli ◽  
Abasic Sites ◽  
Base Excision ◽  
Harmful Effects

ABSTRACT Inappropriate expression of 3-methyladenine (3MeA) DNA glycosylases has been shown to have harmful effects on microbial and mammalian cells. To understand the underlying reasons for this phenomenon, we have determined how DNA glycosylase activity and substrate specificity modulate glycosylase effects in Escherichia coli. We compared the effects of two 3MeA DNA glycosylases with very different substrate ranges, namely, the Saccharomyces cerevisiae Mag1 and the E. coli Tag glycosylases. Both glycosylases increased spontaneous mutation, decreased cell viability, and sensitized E. coli to killing by the alkylating agent methyl methanesulfonate. However, Tag had much less harmful effects than Mag1. The difference between the two enzymes’ effects may be accounted for by the fact that Tag almost exclusively excises 3MeA lesions, whereas Mag1 excises a broad range of alkylated and other purines. We infer that the DNA lesions responsible for changes in spontaneous mutation, viability, and alkylation sensitivity are abasic sites and secondary lesions resulting from processing abasic sites via the base excision repair pathway.

scholarly journals DNA polymerase β and PARP activities in base excision repair in living cells

DNA Repair ◽  
2009 ◽  
Vol 8 (11) ◽  
pp. 1290-1299 ◽  
Author(s):  
Aya Masaoka ◽  
Julie K. Horton ◽  
William A. Beard ◽  
Samuel H. Wilson
Keyword(s):  
Dna Polymerase ◽  
Base Excision Repair ◽  
Excision Repair ◽  
Living Cells ◽  
Dna Polymerase Β ◽  
Base Excision
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