scholarly journals The lac Repressor Protein: Molecular Shape, Subunit Structure, and Proposed Model for Operator Interaction Based on Structural Studies of Microcrystals

1974 ◽  
Vol 71 (3) ◽  
pp. 593-597 ◽  
Author(s):  
T. A. Steitz ◽  
T. J. Richmond ◽  
D. Wise ◽  
D. Engelman
Keyword(s):  
Molecular Shape ◽  
Lac Repressor ◽  
Subunit Structure ◽  
Structural Studies ◽  
Repressor Protein ◽  
Proposed Model ◽  
Operator Interaction

scholarly journals Lysine 84 is at the subunit interface of lac repressor protein

1993 ◽  
Vol 268 (23) ◽  
pp. 17613-17622
Author(s):  
W.I. Chang ◽  
J.S. Olson ◽  
K.S. Matthews
Keyword(s):  
Lac Repressor ◽  
Repressor Protein ◽  
Subunit Interface

Static and Dynamic Structure of Molecular Monomers and Dimers of the Rare-earth Fluorides

2001 ◽  
Vol 56 (5) ◽  
pp. 381-385
Author(s):  
Z. Akdeniz ◽  
M . Gaune-Escard ◽  
M. P. Tosi
Keyword(s):  
Rare Earth ◽  
Bond Length ◽  
Geometrical Structure ◽  
Vibrational Mode ◽  
Dynamic Structure ◽  
Molecular Shape ◽  
Proposed Model ◽  
Infrared Studies ◽  
Charged Clusters ◽  
Good Agreement

Abstract We determine a model of the ionic interactions in RF3 compounds, where R is a rare-earth element in the series from La to Lu, by an analysis of data on the bond length and the vibrational mode frequencies of the PrF3, GdF3 and HoF3 molecular monomers. All RF3 monomers are predicted to have a pyramidal shape, displaying a progressive flattening of the molecular shape in parallel with the lanthanide contraction of the bond length. The vibrational frequencies of all monomers are calculated, the results being in good agreement with the data from infrared studies of matrix-isolated molecules. We also evaluate the geometrical structure and the vibrational spectrum of the La2F6 and Ce2F6 dimers, as a further test of the proposed model. -PACS 36.40.Wa (Charged clusters)

scholarly journals Analysis of the Interaction between the Saccharomyces cerevisiae MSH2-MSH6 and MLH1-PMS1 Complexes with DNA Using a Reversible DNA End-blocking System

2005 ◽  
Vol 280 (23) ◽  
pp. 22245-22257 ◽  
Author(s):  
Marc L. Mendillo ◽  
Dan J. Mazur ◽  
Richard D. Kolodner
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Atp Hydrolysis ◽  
Ternary Complexes ◽  
Lac Repressor ◽  
Dna Molecules ◽  
Direct Dissociation ◽  
Total Internal Reflectance ◽  
Dna Ends ◽  
Internal Reflectance ◽  
Operator Interaction

The Lac repressor-operator interaction was used as a reversible DNA end-blocking system in conjunction with an IAsys biosensor instrument (Thermo Affinity Sensors), which detects total internal reflectance and allows monitoring of binding and dissociation in real time, in order to develop a system for studying the ability of mismatch repair proteins to move along the DNA. The MSH2-MSH6 complex bound to a mispaired base was found to be converted by ATP binding to a form that showed rapid sliding along the DNA and dissociation via the DNA ends and also showed slow, direct dissociation from the DNA. In contrast, the MSH2-MSH6 complex bound to a base pair containing DNA only showed direct dissociation from the DNA. The MLH1-PMS1 complex formed both mispair-dependent and mispair-independent ternary complexes with the MSH2-MSH6 complex on DNA. The mispair-independent ternary complexes were formed most efficiently on DNA molecules with free ends under conditions where ATP hydrolysis did not occur, and only exhibited direct dissociation from the DNA. The mispair-dependent ternary complexes were formed in the highest yield on DNA molecules with blocked ends, required ATP and magnesium for formation, and showed both dissociation via the DNA ends and direct dissociation from the DNA.

lac repressor—Operator interaction

1970 ◽  
Vol 51 (2) ◽  
pp. 303-314 ◽  
Author(s):  
Arthur D. Riggs ◽  
Ronald F. Newby ◽  
Suzanne Bourgeois
Keyword(s):  
Lac Repressor ◽  
Operator Interaction

lac Repressor-operator interaction

1974 ◽  
Vol 85 (2) ◽  
pp. 231-248 ◽  
Author(s):  
Alan Jobe ◽  
John E. Sadler ◽  
Suzanne Bourgeois
Keyword(s):  
Lac Repressor ◽  
Operator Interaction

scholarly journals ION effects on the LAC repressor-operator interaction

1980 ◽  
Vol 32 (1) ◽  
pp. 452-454 ◽  
Author(s):  
Mary D. Barkley ◽  
Phyllis A. Lewis ◽  
Glendon E. Sullivan
Keyword(s):  
Lac Repressor ◽  
Ion Effects ◽  
Operator Interaction
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