scholarly journals Fetal ethanol exposure increases ethanol intake by making it smell and taste better

2009 ◽  
Vol 106 (13) ◽  
pp. 5359-5364 ◽  
Author(s):  
S. L. Youngentob ◽  
J. I. Glendinning
Keyword(s):  
Ethanol Exposure ◽  
Ethanol Intake ◽  
Fetal Ethanol

scholarly journals Role of zinc insufficiency in fetal alveolar macrophage dysfunction and RSV exacerbation associated with fetal ethanol exposure

Alcohol ◽  
2019 ◽  
Vol 80 ◽  
pp. 5-16 ◽  
Author(s):  
Juna Konomi Johnson ◽  
Frank L. Harris ◽  
Xiao-Du Ping ◽  
Theresa W. Gauthier ◽  
Lou Ann S. Brown
Keyword(s):  
Alveolar Macrophage ◽  
Ethanol Exposure ◽  
Macrophage Dysfunction ◽  
Fetal Ethanol

Effect of Modulation of the Astrocytic Glutamate Transporters’ Expression on Cocaine-Induced Reinstatement in Male P Rats Exposed to Ethanol

2020 ◽  
Author(s):  
Alaa M Hammad ◽  
Fawaz Alasmari ◽  
Youssef Sari
Keyword(s):  
Locomotor Activity ◽  
Glutamate Transporter ◽  
Glutamate Transporters ◽  
Ethanol Exposure ◽  
Ethanol Intake ◽  
Cocaine Exposure ◽  
Cocaine Seeking ◽  
Seeking Behavior ◽  
Lactam Antibiotic ◽  
Glutamate Transporter 1

Abstract Aim Reinforcing properties of ethanol and cocaine are mediated in part through the glutamatergic system. Extracellular glutamate concentration is strictly maintained through several glutamate transporters, such as glutamate transporter 1 (GLT-1), cystine/glutamate transporter (xCT) and glutamate aspartate transporter (GLAST). Previous findings revealed that cocaine and ethanol exposure downregulated GLT-1 and xCT, and that β-lactam antibiotics restored their expression. Methods In this study, we investigated the effect of ampicillin/sulbactam (AMP/SUL) (200 mg/kg, i.p.), a β-lactam antibiotic, on cocaine-induced reinstatement and locomotor activity in male alcohol preferring (P) rats using free choice ethanol (15 and 30%, v/v) and water. We also investigated the effect of co-exposure to ethanol and cocaine (20 mg/kg, i.p.) on GLT-1, xCT and GLAST expression in the nucleus accumbens (NAc) core, NAc shell and dorsomedial prefrontal cortex (dmPFC). Results Cocaine exposure decreased ethanol intake and preference. Cocaine and ethanol co-exposure acquired place preference and increased locomotor activity compared to ethanol-exposed rats. GLT-1 and xCT expression were downregulated after cocaine and ethanol co-exposure in the NAc core and shell, but not in dmPFC. AMP/SUL attenuated reinstatement to cocaine as well attenuated the decrease in locomotor activity and ethanol intake and preference. These effects were associated with upregulation of GLT-1 and xCT expression in the NAc core/shell and dmPFC. GLAST expression was not affected after ethanol and cocaine co-exposure or AMP/SUL treatment. Conclusion Our findings demonstrate that astrocytic glutamate transporters within the mesocorticolimbic area are critical targets in modulating cocaine-seeking behavior while being consuming ethanol.

scholarly journals Moderate Adolescent Ethanol Vapor Exposure and Acute Stress in Adulthood: Sex-Dependent Effects on Social Behavior and Ethanol Intake in Sprague–Dawley Rats

2020 ◽  
Vol 10 (11) ◽  
pp. 829
Author(s):  
Meredith E. Gamble ◽  
Marvin R. Diaz
Keyword(s):  
Alcohol Use ◽  
Social Preference ◽  
Stress Reactivity ◽  
Acute Stress ◽  
Ethanol Vapor ◽  
Ethanol Exposure ◽  
Ethanol Intake ◽  
Sprague Dawley ◽  
Long Term Effects ◽  
Sprague Dawley Rats

Adolescent alcohol use can lead to numerous consequences, including altered stress reactivity and higher risk for later anxiety and alcohol use disorders. Many studies have examined the consequences of heavy ethanol exposure in adolescence, but far less is understood about lower levels of intoxication. The present study examined moderate adolescent ethanol exposure as a possible factor in increasing stress reactivity in adulthood, measured through general and social anxiety-like behaviors, as well voluntary ethanol intake. Male and female Sprague–Dawley rats underwent an adolescent chronic intermittent ethanol (aCIE) vapor exposure during early adolescence, reaching moderate blood ethanol concentrations. Animals then underwent two days of forced swim stress in adulthood. We found that ethanol-exposed males consumed more ethanol than their air counterparts and an interesting stress and ethanol exposure interaction in males. There were no significant effects on voluntary drinking in females. However, the social interaction test revealed increased play-fighting behavior in ethanol-exposed females and reduced social preference in females after two days of stress exposure. Overall, this work provides evidence for sex-specific, long-term effects of moderate aCIE and susceptibility to acute stress in adulthood.

Effects of In Vitro Ethanol and Fetal Ethanol Exposure on Glutathione Stimulation of N-Methyl-D-Aspartate Receptor Function

1993 ◽  
Vol 17 (3) ◽  
pp. 643-650 ◽  
Author(s):  
Melanie S. Weaver ◽  
Young-Hee Lee ◽  
Jimmy L. Morris ◽  
Patrick K. Randall ◽  
Timothy Schallert ◽  
...  
Keyword(s):  
Ethanol Exposure ◽  
Receptor Function ◽  
Aspartate Receptor ◽  
Fetal Ethanol ◽  
Stimulation Of

scholarly journals Prenatal ethanol exposure increases ethanol intake and reduces C-fos expression in infralimbic cortex of adolescent rats

2013 ◽  
Vol 103 (4) ◽  
pp. 842-852 ◽  
Author(s):  
Maria Carolina Fabio ◽  
Samanta M. March ◽  
Juan Carlos Molina ◽  
Michael E. Nizhnikov ◽  
Norman E. Spear ◽  
...  
Keyword(s):  
Ethanol Exposure ◽  
Ethanol Intake ◽  
Prenatal Ethanol Exposure ◽  
Infralimbic Cortex ◽  
Adolescent Rats ◽  
Fos Expression
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