scholarly journals Hyperactivity and hyperconnectivity of the default network in schizophrenia and in first-degree relatives of persons with schizophrenia

2009 ◽  
Vol 106 (4) ◽  
pp. 1279-1284 ◽  
Author(s):  
S. Whitfield-Gabrieli ◽  
H. W. Thermenos ◽  
S. Milanovic ◽  
M. T. Tsuang ◽  
S. V. Faraone ◽  
...  
Keyword(s):  
Default Network ◽  
First Degree Relatives ◽  
Persons With Schizophrenia

DEFAULT NETWORK AND MEDIAL PREFRONTAL CORTEX DYSFUNCTION IN SCHIZOPHRENIA AND IN FIRST DEGREE RELATIVES OF PERSONS WITH SCHIZOPHRENIA

2010 ◽  
Vol 117 (2-3) ◽  
pp. 170-171 ◽  
Author(s):  
Larry J. Seidman ◽  
Susan Whitfield-Gabrieli ◽  
Heidi W. Thermenos ◽  
Isabelle Rosso ◽  
Nikos Makris ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Default Network ◽  
First Degree Relatives ◽  
Persons With Schizophrenia

Both low birthweight and high birthweight are associated with cognitive impairment in persons with schizophrenia and their first-degree relatives

2013 ◽  
Vol 43 (11) ◽  
pp. 2361-2367 ◽  
Author(s):  
M. Torniainen ◽  
A. Wegelius ◽  
A. Tuulio-Henriksson ◽  
J. Lönnqvist ◽  
J. Suvisaari
Keyword(s):  
Low Birthweight ◽  
Neuropsychological Test ◽  
Estimating Equation ◽  
Population Based ◽  
Continuous Variable ◽  
First Degree Relatives ◽  
Increased Risk ◽  
Axis I ◽  
Persons With Schizophrenia ◽  
The Relationship

BackgroundBoth low birthweight and high birthweight have been associated with an increased risk for schizophrenia and cognitive impairments in the general population. We assessed the association between birthweight and cognitive performance in persons with schizophrenia and their unaffected first-degree relatives.MethodWe investigated a population-based family sample comprising persons with schizophrenia (n = 142) and their unaffected first-degree relatives (n = 277). Both patients and relatives were interviewed with the Structured Clinical Interview for DSM-IV Axis I Disorders, Clinician Version (SCID-CV) and a comprehensive neuropsychological test battery was administered. Information on birthweight was obtained from obstetric records. We used generalized estimating equation (GEE) models to investigate the effect of birthweight, as a continuous variable, on cognitive functioning, adjusting for within-family correlation and relevant covariates.ResultsBoth low birthweight and high birthweight were associated with lower performance in visuospatial reasoning, processing speed, set-shifting and verbal and visual working memory among persons with schizophrenia and their unaffected first-degree relatives compared to individuals with birthweight in the intermediate range. The group × birthweight interactions were non-significant.ConclusionsBoth low birthweight and high birthweight are associated with deficits in cognition later in life. Schizophrenia does not seem to modify the relationship between birthweight and cognition in families with schizophrenia.

Religious coping in psychiatric patinets and their first-degree relatives

2011 ◽  
Vol 26 (S2) ◽  
pp. 1700-1700
Author(s):  
B. Aukst Margetić ◽  
M. Jakovljević ◽  
D. Ivanec ◽  
G. Tošić ◽  
B. Margetić ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Religious Coping ◽  
Internalized Stigma ◽  
Religious Activities ◽  
Control Subjects ◽  
First Degree Relatives ◽  
Negative Religious Coping ◽  
Persons With Schizophrenia ◽  
Illness Outcomes

ObjectiveThe aim of the study was to examine the prevalence of religious coping among persons with schizophrenia, their first-degree relatives and control subjects and to gain a preliminary understanding of the relationship between religious coping, symptom severity, QOL, level of functioning, internalized stigma and depression. We also examine associations between psychopathology and religiosity in the group of patients.MethodsA total of 120 outpatinets with diagnosis of schizophrenia, 120 their first-degree relatives who also were key caregivers, and 120 control subjects completed a survey consisting of the Religious Coping Index, Quality of Life Enjoyment and Satisfaction Questionnaire-Short Form, Beck Depression Inventory, Internalized Stigma of Mental Illness scale, Positive and Negative Symptom Scale and Global Assessment of Functioning scale.ResultsThe results showed that patients and their relatives were more religious than controls but patients went to church less. Positive religious coping was not associated with illness outcomes, but negative religious coping was associated with worse quality of life, more depression, worse functioning and more internalized stigma. Higher religiosity was associated with higher values of altogether PANSS and positive and general subscales.ConclusionsOur results suggest that religious activities and beliefs are particularly important for the persons with schizophrenia and their caring relatives. Negative religious coping is associated with worse illness outcomes.

Sex differences in cognition among persons with schizophrenia and healthy first-degree relatives

2011 ◽  
Vol 188 (1) ◽  
pp. 7-12 ◽  
Author(s):  
Minna Torniainen ◽  
Jaana Suvisaari ◽  
Timo Partonen ◽  
Anu E. Castaneda ◽  
Annamaria Kuha ◽  
...  
Keyword(s):  
Sex Differences ◽  
First Degree Relatives ◽  
Persons With Schizophrenia
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