scholarly journals Ancient origin of the gene encoding involucrin, a precursor of the cross-linked envelope of epidermis and related epithelia

2008 ◽  
Vol 105 (40) ◽  
pp. 15481-15486 ◽  
Author(s):  
Amandine Vanhoutteghem ◽  
Philippe Djian ◽  
Howard Green
Keyword(s):  
Terminal Differentiation ◽  
Ancient History ◽  
Gene Encoding ◽  
Cornified Envelope ◽  
Good Substrate ◽  
History Of ◽  
The Cross ◽  
Characteristic Product

The cross-linked (cornified) envelope is a characteristic product of terminal differentiation in the keratinocyte of the epidermis and related epithelia. This envelope contains many proteins of which involucrin was the first to be discovered and shown to become cross-linked by a cellular transglutaminase. Involucrin has evolved greatly in placental mammals, but retains the glutamine repeats that make it a good substrate for the transglutaminase. Until recently, it has been impossible to detect involucrin outside the placental mammals, but analysis of the GenBank and Ensembl databases that have become available since 2006 reveals the existence of involucrin in marsupials and birds. We describe here the properties of these involucrins and the ancient history of their evolution.

Newton and the Origin of Civilization

2012 ◽  
Author(s):  
Jed Z. Buchwald ◽  
Mordechai Feingold
Keyword(s):  
Good Reason ◽  
History Of Mathematics ◽  
Primary Sources ◽  
Ancient History ◽  
Isaac Newton ◽  
History Of ◽  
Ancient Civilizations ◽  
And Mathematics ◽  
One Year ◽  
Radical Ideas

Isaac Newton’s Chronology of Ancient Kingdoms Amended, published in 1728, one year after the great man’s death, unleashed a storm of controversy. And for good reason. The book presents a drastically revised timeline for ancient civilizations, contracting Greek history by five hundred years and Egypt’s by a millennium. This book tells the story of how one of the most celebrated figures in the history of mathematics, optics, and mechanics came to apply his unique ways of thinking to problems of history, theology, and mythology, and of how his radical ideas produced an uproar that reverberated in Europe’s learned circles throughout the eighteenth century and beyond. The book reveals the manner in which Newton strove for nearly half a century to rectify universal history by reading ancient texts through the lens of astronomy, and to create a tight theoretical system for interpreting the evolution of civilization on the basis of population dynamics. It was during Newton’s earliest years at Cambridge that he developed the core of his singular method for generating and working with trustworthy knowledge, which he applied to his study of the past with the same rigor he brought to his work in physics and mathematics. Drawing extensively on Newton’s unpublished papers and a host of other primary sources, the book reconciles Isaac Newton the rational scientist with Newton the natural philosopher, alchemist, theologian, and chronologist of ancient history.

FORMATION OF CULTURE OF THE CITY OF JIZAK

2019 ◽  
Vol 22 (2) ◽  
pp. 62-65
Author(s):  
Dilbar Abdurasulova ◽  
◽  
Akbar Màjidov
Keyword(s):  
Ancient History ◽  
Greco Roman ◽  
History Of ◽  
The City ◽  
Chinese Travelers

This article provide that Uzbekistan is one of the oldest centers of culture, in particular, the works of Greco-Roman historians, Arab and Chinese travelers and geographers serve invaluable source for studying the ancient history of Jizzak

ABOUT THE PERIODIZATION AND CHRONOLOGY OF THE HISTORY OF TAURIC CHERSONESUS IN THE PRE-ROMAN AND THE LATE ANTIQUE PERIODS

2020 ◽  
Vol 6 (72) (3) ◽  
pp. 127-148
Author(s):  
S. V. Ushakov
Keyword(s):  
Scientific Literature ◽  
Early Stage ◽  
Late Antique ◽  
Ancient History ◽  
History Of ◽  
Transitional Time ◽  
Early Byzantine

Hundreds of scientific works are devoted to the study of the Tauric Chersonesus, but the problem of chronology and periodization of its ancient history is not sufficiently developed in historiography. Analysis of scientific literature and a number of sources concerning this subject allows to define the chronological framework and to reveal 10 stages of the history of ancient Chersonesos (as a preliminary definition). The early stage, the Foundation and formation of the Polis, is defined from the middle/last third of the VI century (or the first half of the V century BC) to the end of the V century BC. The end of the late-Antique − early-Byzantine (transitional) time in Chersonesos can be attributed to the second half of the VI – first third of the VII centuries ad).

Getting Jesus off the altar: Undoing atonement readings in Revelation

2021 ◽  
Vol 118 (1) ◽  
pp. 54-61
Author(s):  
Anna M. V. Bowden
Keyword(s):  
The Other ◽  
History Of ◽  
The Cross

The interpretive history of Revelation is overrun with descriptions of Jesus as a sacrificial lamb. Yet, John never uses the popular phrase to describe him. By drawing attention to four significant omissions in the text, I argue against atonement readings of “the Lamb” in Revelation. Revelation is not a theological treatise on the meaning of the cross. It feeds questions about power and violence and admonishes the seven churches against participation in their imperial context. John’s slaughtered lamb, therefore, does not evoke a paschal sacrifice; it points to Rome’s penchant for violence. Joining the other bloodied bodies in Revelation, the lamb’s blood further incriminates Rome. Everywhere one looks in John’s depiction of empire, violence lurks. Finally, the only altar in Revelation is the heavenly altar, and this altar is not a place for sacrifice. The heavenly altar is a place where the laments of the suffering are heard, a place for worshipping God, and a place where Rome will meet its judgment. John’s Jesus is not a self-sacrificing spiritual savior; he bears witness to the bloodthirsty, massacre-loving beast-of-all-beasts. Churches must choose their allegiance.

Subfunctionalization of Duplicate mitf Genes Associated With Differential Degeneration of Alternative Exons in Fish

Genetics ◽  
2002 ◽  
Vol 161 (1) ◽  
pp. 259-267 ◽  
Author(s):  
Joachim Altschmied ◽  
Jacqueline Delfgaauw ◽  
Brigitta Wilde ◽  
Jutta Duschl ◽  
Laurence Bouneau ◽  
...  
Keyword(s):  
Danio Rerio ◽  
Evolutionary History ◽  
Single Gene ◽  
Regulatory Elements ◽  
Fugu Rubripes ◽  
Gene Encoding ◽  
Tetraodon Nigroviridis ◽  
Mammalian Lineage ◽  
History Of ◽  
Fish Proteins

Abstract The microphthalmia-associated transcription factor (MITF) exists in at least four isoforms. These are generated in higher vertebrates using alternative 5′ exons and promoters from a single gene. Two separate genes (mitf-m and mitf-b), however, are present in different teleost fish species including the poeciliid Xiphophorus, the pufferfishes Fugu rubripes and Tetraodon nigroviridis, and the zebrafish Danio rerio. Fish proteins MITF-m and MITF-b correspond at both the structural and the expression levels to one particular bird/mammalian MITF isoform. In the teleost lineage subfunctionalization of mitf genes after duplication at least 100 million years ago is associated with the degeneration of alternative exons and, probably, regulatory elements and promoters. For example, a remnant of the first exon specific for MITF-m is detected within the pufferfish gene encoding MITF-b. Retracing the evolutionary history of mitf genes in vertebrates uncovered the differential recruitment of new introns specific for either the teleost or the bird/mammalian lineage.

scholarly journals Sexuality and Affection in the Time of Technological Innovation: Artificial Partners in the Japanese Context

Religions ◽  
2021 ◽  
Vol 12 (5) ◽  
pp. 296
Author(s):  
Beatriz Yumi Aoki ◽  
Takeshi Kimura
Keyword(s):  
18Th Century ◽  
Human Life ◽  
Human Sexuality ◽  
Sexual Intimacy ◽  
Ancient History ◽  
Human Relationships ◽  
Living Things ◽  
Long Time ◽  
History Of ◽  
The Impact

Recent years have witnessed an increase in the number of academic studies on the impact of technological advancements on human life, including possible transformations and changes in human sexuality following the development of sex-related devices, such as sex robots. In this context, terms such as posthuman sexuality, digisexuality, and techno-sexuality have emerged, signaling possible new understandings of sexual, intimacy, and emotional practices. It is important to note that ancient history shows that humankind has for a long time been fascinated with their relationship to non-living things, mostly human-like figures, such as dolls. The Ningyo (人形, the Japanese term for doll) has a long history of usage, and has deep religious and animistic significance in the Japanese context—there are records of sexual use as early as the 18th century. With this context in mind, this paper focuses on three Japanese examples, aiming to shine a light on beyond-human relationships, which include a Japanese man’s marriage to a digital character, sex dolls, and communicative robots, from both a sexual and emotional perspective. In a new horizon of sexual and romantic possibilities, how will humans respond, and what can emerge from these interactions?

scholarly journals Art. II.—Samudra Gupta (A specimen chapter of the projected Ancient History of Northern India from the Monuments.)

1897 ◽  
Vol 29 (1) ◽  
pp. 19-33
Author(s):  
Vincent A. Smith
Keyword(s):  
Fourth Century ◽  
Ancient History ◽  
The South ◽  
Ancient India ◽  
Northern India ◽  
History Of

The following history of the reign of the great conqueror, Samudra Gupta, who was emperor of Northern India, and made extensive, though temporary, conquests in the south, about the middle of the fourth century of the Christian era, is offered as a specimen of the author's projected “Ancient History of Northern India from the Monuments.” Though that projected history may never be completed, I venture to think that fragments of it may not be altogether valueless, and that they may suffice to prove that even now the materials exist for the construction of an authentic and fairly readable “History of Ancient India.”

Serjeant Knight's Discourse on the Cross and Flags of St George (1678)

2001 ◽  
Vol 81 ◽  
pp. 351-390
Author(s):  
C S Knighton ◽  
Timothy Wilson
Keyword(s):  
Seventeenth Century ◽  
Dominant Feature ◽  
History Of ◽  
The Cross ◽  
Charles Ii ◽  
Manuscript Copy ◽  
Samuel Pepys ◽  
Original Drawings

In January 1678 John Knight, the Serjeant Surgeon of Charles II, sent to Samuel Pepys a ‘Discourse containing the History of the Cross of St. George, and its becoming the Sole Distinction = Flag, Badge or Cognizance of England, by Sea and Land’. Knight argued that St George's cross should become the dominant feature in English flags and supported his argument with a history of the cross.A manuscript copy of this discourse, with Knight's original drawings, survives in the Pepys Library, Magdalene College, Cambridge, and is published here. A brief biography of Knight is presented and an account of sixteenth- and seventeenth-century controversies about St George. The latter was an issue which caused acrimony between Royalists and Puritans. An Appendix reconstructs Knight's library, principally consisting of books concerning heraldry, topography and history.

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