scholarly journals The nuclear corepressor, NCoR, regulates thyroid hormone action in vivo

2008 ◽  
Vol 105 (49) ◽  
pp. 19544-19549 ◽  
Author(s):  
I. Astapova ◽  
L. J. Lee ◽  
C. Morales ◽  
S. Tauber ◽  
M. Bilban ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Hormone Action ◽  
Thyroid Hormone Action

scholarly journals Thyroid Hormone and Wound Healing

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Joshua D. Safer
Keyword(s):  
Wound Healing ◽  
Thyroid Hormone ◽  
Thyroid Disease ◽  
Hair Growth ◽  
Therapeutic Potential ◽  
Hormone Action ◽  
Review Of The Literature ◽  
Thyroid Hormone Action

Although thyroid hormone is one of the most potent stimulators of growth and metabolic rate, the potential to use thyroid hormone to treat cutaneous pathology has never been subject to rigorous investigation. A number of investigators have demonstrated intriguing therapeutic potential for topical thyroid hormone. Topical T3has accelerated wound healing and hair growth in rodents. Topical T4has been used to treat xerosis in humans. It is clear that the use of thyroid hormone to treat cutaneous pathology may be of large consequence and merits further study. This is a review of the literature regarding thyroid hormone action on skin along with skin manifestations of thyroid disease. The paper is intended to provide a context for recent findings of direct thyroid hormone action on cutaneous cellsin vitroandin vivowhich may portend the use of thyroid hormone to promote wound healing.

scholarly journals Thyroid hormone action in the absence of thyroid hormone receptor DNA-binding in vivo

2003 ◽  
Vol 112 (4) ◽  
pp. 588-597 ◽  
Author(s):  
Nobuyuki Shibusawa ◽  
Koshi Hashimoto ◽  
Amisra A. Nikrodhanond ◽  
M. Charles Liberman ◽  
Meredithe L. Applebury ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Dna Binding ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Hormone Action ◽  
Thyroid Hormone Action

Effects of Thyroid Function on Phosphodiester Concentrations in Skeletal Muscle and Liver: An In Vivo NMRS Study

2020 ◽  
Vol 105 (12) ◽  
pp. e4866-e4874
Author(s):  
Hannes Beiglböck ◽  
Peter Wolf ◽  
Lorenz Pfleger ◽  
Burak Caliskan ◽  
Paul Fellinger ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Thyroid Hormone ◽  
Thyroid Function ◽  
Thyroid Stimulating Hormone ◽  
Resonance Spectroscopy ◽  
Hormone Action ◽  
Tissue Specific ◽  
Ectopic Tissue ◽  
Thyroid Hormone Action

Abstract Context Thyroid function is clinically evaluated by determination of circulating concentrations of thyrotropin (thyroid-stimulating hormone; TSH) and free thyroxine (fT4). However, a tissue-specific effector substrate of thyroid function is lacking. Energy-rich phosphorus-containing metabolites (PM) and phospholipids (PL) might be affected by thyroid hormone action and can be noninvasively measured by 31P nuclear magnetic resonance spectroscopy (NMRS). Objectives To measure the actions of peripheral thyroid hormones on PM and PL tissue concentrations. Design and Setting A longitudinal, prospective pilot study was performed. Participants Nine patients with hyperthyroidism (HYPER) and 4 patients with hypothyroidism (HYPO) were studied at baseline and 3 months after treatment. Main Outcome Measures High-field 1H/31P NMRS was used to assess profiles of PM, PL, and flux through oxidative phosphorylase in liver and skeletal muscle, as well as ectopic tissue lipid content. Results The concentrations of total skeletal muscle (m-) and hepatic (h-) phosphodiesters (PDE) and one of the PDE constituents, glycerophosphocholine (GPC), were lower in HYPER compared with HYPO (m-PDE: 1.4 ± 0.4 mM vs 7.4 ± 3.5 mM, P = 0.003; m-GPC: 0.9 ± 0.3 mM vs 6.7 ± 3.5 mM, P = 0.003; h-PDE: 4.4 ± 1.4 mM vs 9.9 ± 3.9 mM, P = 0.012; h-GPC: 2.2 ± 1.0 mM vs 5.1 ± 2.4 mM, P = 0.024). Both h-GPC (rho = −0.692, P = 0.018) and h-GPE (rho = −0.633, P = 0.036) correlated negatively with fT4. In muscle tissue, a strong negative association between m-GPC and fT4 (rho = −0.754, P = 0.003) was observed. Conclusions Thyroxine is closely negatively associated with the PDE concentrations in liver and skeletal muscle. Normalization of thyroid dysfunction resulted in a decline of PDE in hypothyroidism and an increase in hyperthyroidism. Thus, PDE might be a sensitive tool to estimate tissue-specific peripheral thyroid hormone action.

Molecular mechanisms of sex-dependent thyroid hormone action on target tissues

2014 ◽  
Vol 122 (03) ◽  
Author(s):  
H Rakov ◽  
K Engels ◽  
D Zwanziger ◽  
M Renders ◽  
K Brix ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Molecular Mechanisms ◽  
Hormone Action ◽  
Thyroid Hormone Action

Growth hormone treatment in children with idiopathic short stature: correlation of growth response with peripheral thyroid hormone action

2011 ◽  
Vol 74 (3) ◽  
pp. 346-353 ◽  
Author(s):  
Sebastián Susperreguy ◽  
Liliana Muñoz ◽  
Natalia Y. Tkalenko ◽  
Ivan D. Mascanfroni ◽  
Vanina A. Alamino ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Thyroid Hormone ◽  
Short Stature ◽  
Growth Response ◽  
Growth Hormone Treatment ◽  
Hormone Treatment ◽  
Idiopathic Short Stature ◽  
Hormone Action ◽  
Thyroid Hormone Action
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