scholarly journals Mechanical feedback as a possible regulator of tissue growth

2005 ◽  
Vol 102 (9) ◽  
pp. 3318-3323 ◽  
Author(s):  
B. I. Shraiman
Keyword(s):  
Tissue Growth ◽  
Mechanical Feedback

scholarly journals The statistics of noisy growth with mechanical feedback in elastic tissues

2018 ◽  
Author(s):  
Ojan Khatib Damavandi ◽  
David K. Lubensky
Keyword(s):  
Tissue Growth ◽  
Fundamental Aspect ◽  
Isotropic Case ◽  
Anisotropic Growth ◽  
Clone Size ◽  
Density Correlation ◽  
Precise Control ◽  
Growth Modes ◽  
Elastic Sheets ◽  
Mechanical Feedback

Tissue growth is a fundamental aspect of development and is intrinsically noisy. Stochasticity has important implications for morphogenesis, precise control of organ size, and regulation of tissue composition and heterogeneity. Yet, the basic statistical properties of growing tissues, particularly when growth induces mechanical stresses that can in turn affect growth rates, have received little attention. Here, we study the noisy growth of elastic sheets subject to mechanical feedback. Considering both isotropic and anisotropic growth, we find that the density-density correlation function shows power law scaling. We also consider the dynamics of marked, neutral clones of cells. We find that the areas (but not the shapes) of two clones are always statistically independent, even when they are adjacent. For anisotropic growth, we show that clone size variance scales like the average area squared and that the mode amplitudes characterizing clone shape show a slow 1/n decay, where n is the mode index. This is in stark contrast to the isotropic case, where relative variations in clone size and shape vanish at long times. The high variability in clone statistics observed in anisotropic growth is due to the presence of two soft modes—growth modes that generate no stress. Our results lay the groundwork for more in-depth explorations of the properties of noisy tissue growth in specific biological contexts.

scholarly journals Statistics of noisy growth with mechanical feedback in elastic tissues

2019 ◽  
Vol 116 (12) ◽  
pp. 5350-5355 ◽  
Author(s):  
Ojan Khatib Damavandi ◽  
David K. Lubensky
Keyword(s):  
Tissue Growth ◽  
Fundamental Aspect ◽  
Isotropic Case ◽  
Anisotropic Growth ◽  
Clone Size ◽  
Density Correlation ◽  
Precise Control ◽  
Growth Modes ◽  
Elastic Sheets ◽  
Mechanical Feedback

Tissue growth is a fundamental aspect of development and is intrinsically noisy. Stochasticity has important implications for morphogenesis, precise control of organ size, and regulation of tissue composition and heterogeneity. However, the basic statistical properties of growing tissues, particularly when growth induces mechanical stresses that can in turn affect growth rates, have received little attention. Here, we study the noisy growth of elastic sheets subject to mechanical feedback. Considering both isotropic and anisotropic growth, we find that the density–density correlation function shows power law scaling. We also consider the dynamics of marked, neutral clones of cells. We find that the areas (but not the shapes) of two clones are always statistically independent, even when they are adjacent. For anisotropic growth, we show that clone size variance scales like the average area squared and that the mode amplitudes characterizing clone shape show a slow1/ndecay, where n is the mode index. This is in stark contrast to the isotropic case, where relative variations in clone size and shape vanish at long times. The high variability in clone statistics observed in anisotropic growth is due to the presence of two soft modes—growth modes that generate no stress. Our results lay the groundwork for more in-depth explorations of the properties of noisy tissue growth in specific biological contexts.

Rheometers, Bioreactors, and Vocalization Forces: Using Basic Science Investigations to Help the Voices of Teachers

2008 ◽  
Vol 18 (3) ◽  
pp. 119-125
Author(s):  
Sarah Klemuk
Keyword(s):  
Basic Science ◽  
Tissue Growth ◽  
University Of Iowa ◽  
Support Cell ◽  
Rest Periods ◽  
Collaborative Studies ◽  
Professional Voice Users ◽  
The University ◽  
Science Investigations ◽  
Professional Voice

Abstract Collaborative studies at the University of Iowa and the National Center for Voice and Speech aim to help the voices of teachers. Investigators study how cells and tissues respond to vibration doses simulating typical vocalization patterns of teachers. A commercially manufactured instrument is uniquely modified to support cell and tissue growth, to subject tissues to vocalization-like forces, and to measure viscoelastic properties of tissues. Through this basic science approach, steps toward safety limits for vocalization and habilitating rest periods for professional voice users will be achieved.

Identification of connective tissue growth factor as a hepatic negative acute phase protein

Hepatology ◽  
2009 ◽  
pp. NA-NA
Author(s):  
Ieva Peredniene ◽  
Eddy van de Leur ◽  
Birgit Lahme ◽  
Monika Siluschek ◽  
Axel M. Gressner ◽  
...  
Keyword(s):  
Growth Factor ◽  
Connective Tissue ◽  
Connective Tissue Growth Factor ◽  
Acute Phase ◽  
Acute Phase Protein ◽  
Tissue Growth ◽  
Phase Protein
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