scholarly journals Conjugation of benzoic acid in marsupials

1985 ◽  
Vol 33 (5) ◽  
pp. 693 ◽  
Author(s):  
Almah Bt. Awaluddin ◽  
Stuart McLean
Keyword(s):  
Benzoic Acid ◽  
Metabolic Pathway ◽  
Hippuric Acid ◽  
Urinary Metabolites ◽  
Carbon Fragment ◽  
Marsupial Species ◽  
Glycine Conjugate

The urinary metabolites of benzoic acid have been studied in seven marsupial species and the rat. Benzoic acid was excreted mainly as the glycine conjugate, hippuric acid, with smaller, though variable, amounts as benzoyl glucuronide. Thus the overall pattern of metabolism was similar to that found in most other mammals. All species formed significant amounts of a recently discovered metabolite of benzoic acid, 0-hydroxyphenylpropionic acid, suggesting that the metabolic pathway for its formation, involving the addition of a two-carbon fragment, may occur generally in other species.

scholarly journals Excretion of benzoic acid derivatives in urine of sheep given intraruminal infusions of 3-phenylpropionic and cyclohexanecarboxylic acids

1997 ◽  
Vol 77 (4) ◽  
pp. 577-592 ◽  
Author(s):  
J. H. Pagella ◽  
X. B. Chen ◽  
N. A. Macleod ◽  
E. R. Ørskov ◽  
P. J. S. Dewey
Keyword(s):  
Benzoic Acid ◽  
Urinary Excretion ◽  
Hippuric Acid ◽  
Quantitative Relationship ◽  
The Other ◽  
Urinary Recovery ◽  
Faecal Excretion ◽  
Benzoic Acid Derivatives ◽  
Significant Linear Correlation ◽  
Glycine Conjugate

The quantitative relationship between the urinary excretion of benzoic acid (BA)and the uptake of 3-phenylpropionic (PPA) and cyclohexanecarboxylic (CHCA) acids was assessed.PPA and CHCA are produced in the rumen by microbial fermentation of lignocellulosic feeds and metabolized, after absorption, to BA which is excreted in the urine mainly as its glycine conjugate hippuric acid (HA). Four sheep nourished by intragastric infusions of all nutrients weregiven continuous ruminal infusions of PPA (8,16 or 24 mmol/d) either alone or with CHCA (8 or 16 mmol/d) in a factorial experiment. The treatments were allocated to ten consecutive 6 d periods, with a control being repeated at periods 1, 5 and 10. PPA and CHCA ruminal absorption rates, estimated using the liquid-phase marker Cr-EDTA, were 0·78 (SD 0·29)/h and 0·88 (SD 0·28)/h respectively. For the control, HA excretion was only 0·22 (SD 0·33) mmol/d and free BA was absent. For the other treatments, both HA and free BA were present and HA accounted for 0·85 (SD 0·05) of total BA. The urinary excretion of total BA showed a significant linear correlation (r = 0·997, P<0·001) with the amounts of PPA and CHCA infused. The urinary recovery of infused PPA and CHCA as total BA was 0·79 (SE 0·01). Faecal excretion of BA and its precursors was negligible. Results of this study show that urinary total BA is a potential estimator of the absorption of PPA + CHCA produced in the rumen

Urinary excretion of benzoic acid and hippuric acid in sheep given ruminal infusion of 3-phenylpropionic and cyclohexanecarboxylic acids

1996 ◽  
Vol 1996 ◽  
pp. 179-179
Author(s):  
J.H. Pagella ◽  
X.B. Chen ◽  
N.A. MacLeod ◽  
E.R. Ãrskov
Keyword(s):  
Benzoic Acid ◽  
Urinary Excretion ◽  
Hippuric Acid ◽  
Quantitative Relationship ◽  
Microbial Metabolism ◽  
Microbial Fermentation ◽  
Cinnamic Acids ◽  
Glycine Conjugate ◽  
Microbial Action

Microbial fermentation of lignoceluUosic feeds in the rumen produces 3-phenylpropionic (PPA) and cyclohexanecarboxylic (CHCA) acids. Feed phenolic cinnamic acids are regarded as the main precursors of PPA upon microbial action (Martin 1982b). CHCA can be produced by microbial metabolism of dietary alicyclic compounds such as quinic and shikimic acids (Balba and Evans, 1977; Martin, 1982a). Following absorption CHCA and PPA are subjected to metabolism mainly in the liver yielding benzoic acid (BA) which is extensively excreted in urine mainly as its glycine conjugate hippuric acid (HA). The aim of this work was to assess the quantitative relationship between the urinary excretion of total BA (free BA + HA) and the uptake of PPA and CHCA.

Urinary excretion of benzoic acid and hippuric acid in sheep given ruminal infusion of 3-phenylpropionic and cyclohexanecarboxylic acids

1996 ◽  
Vol 1996 ◽  
pp. 179-179
Author(s):  
J.H. Pagella ◽  
X.B. Chen ◽  
N.A. MacLeod ◽  
E.R. Ãrskov
Keyword(s):  
Benzoic Acid ◽  
Urinary Excretion ◽  
Hippuric Acid ◽  
Quantitative Relationship ◽  
Microbial Metabolism ◽  
Microbial Fermentation ◽  
Cinnamic Acids ◽  
Glycine Conjugate ◽  
Microbial Action

Microbial fermentation of lignoceluUosic feeds in the rumen produces 3-phenylpropionic (PPA) and cyclohexanecarboxylic (CHCA) acids. Feed phenolic cinnamic acids are regarded as the main precursors of PPA upon microbial action (Martin 1982b). CHCA can be produced by microbial metabolism of dietary alicyclic compounds such as quinic and shikimic acids (Balba and Evans, 1977; Martin, 1982a). Following absorption CHCA and PPA are subjected to metabolism mainly in the liver yielding benzoic acid (BA) which is extensively excreted in urine mainly as its glycine conjugate hippuric acid (HA). The aim of this work was to assess the quantitative relationship between the urinary excretion of total BA (free BA + HA) and the uptake of PPA and CHCA.

scholarly journals Production of Benzoic Acid in Fermented Goat's and Sheep's Milk

2015 ◽  
Vol 45 (4) ◽  
pp. 247-253 ◽  
Author(s):  
Š. Horníčková ◽  
H. Dragounová ◽  
K. Hejtmánková ◽  
T. Michlová ◽  
A. Hejtmánková
Keyword(s):  
Benzoic Acid ◽  
Hippuric Acid ◽  
Fermented Milk ◽  
Milk Fermentation ◽  
Significant Difference ◽  
Different Cultures ◽  
Dairy Fermentation

Abstract The content of hippuric acid in raw goat's and sheep's milk and the content of benzoic acid in model fermented milk drinks prepared using different cultures of bacteria of milk fermentation were determined. All fermented milk drinks contained benzoic acid in the range 5.0-78 mg kg-1. Higher quantity of benzoic acid in fermented sheep's milk drinks corresponded also to significantly higher quantity of hippuric acid in raw sheep's milk. No significant differences among used cultures of bacteria of dairy fermentation and the quantity of benzoic acid in fermented milk drinks were recorded. In addition, the quantity of benzoic acid in various commercial goat's and sheep's cheeses produced directly in farms was analyzed. The contents of benzoic acid in cheeses ranged from 5.1 to 90 mg kg-1. No significant difference in the quantity of benzoic acid from goat's and sheep's cheeses was found, whereas significant differences were registered in the quantity of benzoic acid in cheeses produced in individual farms.

Evidence for the occurrence of a novel pathway of benzoic acid metabolism involving the addition of a two carbon fragment

1981 ◽  
Vol 30 (13) ◽  
pp. 1879-1882 ◽  
Author(s):  
Mary Varwell Marsh ◽  
Andrew J. Hutt ◽  
John Caldwell ◽  
Robert L. Smith ◽  
Marion W. Horner ◽  
...  
Keyword(s):  
Benzoic Acid ◽  
Acid Metabolism ◽  
Carbon Fragment
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