A Comparison of Anaerobic Energy Metabolism in Mantle and Tentacle Muscle of the Blue-Ringed Octopus, Hapalochlaena maculosa, During Swimming

1980 ◽  
Vol 28 (3) ◽  
pp. 407 ◽  
Author(s):  
J Baldwin ◽  
WR England
Keyword(s):  
Lactate Dehydrogenase ◽  
Energy Metabolism ◽  
Energy Charge ◽  
Anaerobic Glycolysis ◽  
Atp Production ◽  
Glycerophosphate Dehydrogenase ◽  
Anaerobic Energy ◽  
Octopine Dehydrogenase

The blue-ringed octopus Hapalochlaena maculosa uses both the mantle and tentacles for swimming. Activities of octopine dehydrogenase. lactate dehydrogenase and alpha-glycerophosphate dehydrogenase in mantle and tentacle muscles indicate that both tissues depend on anaerobic glycolysis during swimming. with octopine rather than lactate accumulating as an end product. Following swimming. both mantle and tentacles show a decrease in arginine phosphate, an increase in octopine. and a fall in energy charge. On the basis of ATP equivalents per grain of muscle obtained from arginine phosphate and anaerobic glycolysis, the two tissues are similar, but when the relative muscle weights are taken into account ATP production is at least 10-fold greater in the tentacles than in the mantle.

Re-examination of the contributions of aerobic and anaerobic energy production during swimming in the Bivalve mollusc Limaria fragilis (Family Limidae)

1983 ◽  
Vol 34 (6) ◽  
pp. 909 ◽  
Author(s):  
J Baldwin ◽  
GM Morris
Keyword(s):  
Energy Production ◽  
Arginine Kinase ◽  
Adductor Muscle ◽  
Aerobic Metabolism ◽  
Anaerobic Glycolysis ◽  
Atp Production ◽  
Minor Contribution ◽  
Anaerobic Energy ◽  
A Minor ◽  
Aerobic And Anaerobic

The file shell L. fragilis displays a slow sustained style of swimming indicative of basically aerobic mechanisms of ATP production. Although it had been proposed that anaerobic glycolysis and arginine phosphate did not contribute to powering swimming, the discovery of high activity of arginine kinase and significant activities of strombine and alanopine dehydrogenases in the adductor muscle led to a reexamination of the relative contributions of aerobic metabolism, anaerobic glycolysis and arginine phosphate during swimming. It was found that, whereas aerobic metabolism predominates with only a minor contribution from anaerobic glycolysis, arginine phosphate supplied up to 23% of the ATP used during 5 min of sustained swimming.

Energy Production and Utilization by Human Platelets in the Presence of Some Guanidines and Phenols (Uremic Toxins) that Inhibit Aggregation

1975 ◽  
Vol 34 (01) ◽  
pp. 063-071 ◽  
Author(s):  
Hugh J Carroll
Keyword(s):  
Platelet Aggregation ◽  
Energy Metabolism ◽  
Human Platelets ◽  
Uremic Toxins ◽  
Anaerobic Glycolysis ◽  
Excessive Bleeding ◽  
Atp Production ◽  
Uremic Patients ◽  
Induced Aggregation

SummaryPlatelet aggregation induced by ADP can be inhibited by plasma from uremic patients or by toxins isolated from their plasma, e. g. guanidinosuccinic acid, methylguanidine, phenol and hydroxyphenylacetic acids. Since these chemical substances can interfere with energy metabolism in tissues other than platelets and since ATP production is needed for ADP-induced aggregation, alterations in platelet energy metabolism could underlie excessive bleeding in uremic patients. Platelets incubated with idioacetate and deprived of anaerobic glycolysis produced the same quantity of ATP through respiration in the presence of all the uremic toxins studied as in their absence. Similarly, platelets incubated with cyanide and deprived of the oxidative pathway utilized anaerobic glycolysis to produce normal quantities of ATP in the presence of all the uremic toxins. The utilization of ATP, as indicated by active transmembrane potassium transport, was also unaffected by the above listed guanidines and phenols. It is concluded that the in vitro inhibition of ADP-induced platelet aggregation by the guanidines and phenols studied is not due to inhibition of production or utilization of ATP.

Metabolomic profiling of anaerobic and aerobic energy metabolic pathways in chronic obstructive pulmonary disease

2021 ◽  
pp. 153537022110088
Author(s):  
Mingshan Xue ◽  
Yifeng Zeng ◽  
Runpei Lin ◽  
Hui-Qi Qu ◽  
Teng Zhang ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Energy Metabolism ◽  
Pulmonary Disease ◽  
Metabolic Pathways ◽  
Energy Supply ◽  
Stable Phase ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients ◽  
Anaerobic Energy

While there is no cure for chronic obstructive pulmonary disease (COPD), its progressive nature and the formidable challenge to manage its symptoms warrant a more extensive study of the pathogenesis and related mechanisms. A new emphasis on COPD study is the change of energy metabolism. For the first time, this study investigated the anaerobic and aerobic energy metabolic pathways in COPD using the metabolomic approach. Metabolomic analysis was used to investigate energy metabolites in 140 COPD patients. The significance of energy metabolism in COPD was comprehensively explored by the Global Initiative for Chronic Obstructive Lung Disease–GOLD grading, acute exacerbation vs. stable phase (either clinical stability or four-week stable phase), age group, smoking index, lung function, and COPD Assessment Test (CAT) score. Through comprehensive evaluation, we found that COPD patients have a significant imbalance in the aerobic and anaerobic energy metabolisms in resting state, and a high tendency of anaerobic energy supply mechanism that correlates positively with disease progression. This study highlighted the significance of anaerobic and low-efficiency energy supply pathways in lung injury and linked it to the energy-inflammation-lung ventilatory function and the motion limitation mechanism in COPD patients, which implies a novel therapeutic direction for this devastating disease.

Evolutionary Consequences of Tradeoffs between Yield and Rate of ATP Production

2002 ◽  
Vol 216 (1) ◽  
Author(s):  
Thomas Pfeiffer ◽  
Sebastian Bonhoeffer
Keyword(s):  
Game Theory ◽  
Population Dynamics ◽  
Energy Metabolism ◽  
Adenosine Triphosphate ◽  
Organic Material ◽  
High Yield ◽  
Atp Production ◽  
Cellular Processes ◽  
Quantitative Properties ◽  
Evolutionary Consequences

Adenosine triphosphate (ATP) is a key compound in the energy metabolism of cells and is required to drive vital biochemical reactions. In heterotrophic organisms ATP production is coupled to the degradation of energy-rich organic material taken up from the environment. In the transfer of the environmental energy to cellular processes heterotrophs face a tradeoff, since the conversion of the environmental energy into ATP cannot be both maximally fast and efficient. Here we show how tradeoffs between rate and yield of ATP production arise firstly from thermodynamical principles, and secondly for the ATP production by respiration and fermentation. Using methods derived from game theory and population dynamics we investigate the evolutionary consequences for both tradeoffs. We show that spatially structured environments enable the evolution of efficient pathways with high yield. The strategies of ATP production realized in a population, however, depend on the quantitative properties of the tradeoffs.

scholarly journals MODELING THE EFFECTS OF LEAD POLLUTION ON LACTATE DEHYDROGENASE ACTIVITY

10.23856/3305 ◽  
2019 ◽  
Vol 33 (2) ◽  
pp. 50-55
Author(s):  
Olena Konovalova
Keyword(s):  
Heavy Metals ◽  
Lactate Dehydrogenase ◽  
Energy Metabolism ◽  
Lead Acetate ◽  
Lead Pollution ◽  
Lactate Dehydrogenase Activity ◽  
Influence Mechanism ◽  
Ldh Activity ◽  
Small Doses ◽  
Experimental Substantiation

The changes of activity of LDH and its isoenzymatic fractions under load with lead acetate are described. The introduction of a subacute dose of Pb2 + led to a decrease in the LDH activity of the rat liver and an increase in the heart. Preliminary introduction of small doses of Pb2 + partially prevents increased LDH activity in the heart and completely inhibits its increase in the liver. The proportion of urea-stable fraction in the heart and blood serum is significantly increased, indicating an increase in the aerobic direction of energy metabolism. The obtained results are the experimental substantiation of further investigations of influence mechanism of heavy metals on the organism, as well as the motivation to prevent environmental pollution by man-made xenobiotics.

Sign in / Sign up

Export Citation Format

Share Document