Awareness and knowledge of anal cancer in a community-recruited sample of HIV-negative and HIV-positive gay and bisexual men

Sexual Health ◽  
2019 ◽  
Author(s):  
Lance Feeney ◽  
Mary Poynten ◽  
Fengyi (Jeff) Jin ◽  
Craig Cooper ◽  
David J. Templeton ◽  
...  
Keyword(s):  
Anal Cancer ◽  
Gay And Bisexual Men ◽  
Hiv Positive ◽  
Bisexual Men ◽  
And Bisexual ◽  
Hiv Negative

Impact of combination therapies on HIV risk perceptions and sexual risk among HIV-positive and HIV-negative gay and bisexual men.

2000 ◽  
Vol 19 (2) ◽  
pp. 134-145 ◽  
Author(s):  
Peter A. Vanable ◽  
David G. Ostrow ◽  
David J. McKirnan ◽  
Kittiwut J. Taywaditep ◽  
Brent A. Hope
Keyword(s):  
Sexual Risk ◽  
Hiv Risk ◽  
Risk Perceptions ◽  
Gay And Bisexual Men ◽  
Hiv Positive ◽  
Bisexual Men ◽  
Combination Therapies ◽  
And Bisexual ◽  
Hiv Negative

HIV, immune dysfunction and the natural history of anal high-risk human papillomavirus infection in gay and bisexual men

2020 ◽  
Author(s):  
I Mary Poynten ◽  
Fengyi Jin ◽  
Suzanne M Garland ◽  
Richard J Hillman ◽  
Monica Molano ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
High Risk ◽  
Natural History ◽  
Anal Cancer ◽  
Gay And Bisexual Men ◽  
Hiv Positive ◽  
Bisexual Men ◽  
Clearance Rates ◽  
History Of ◽  
And Bisexual

Abstract Objectives Incidence of anal cancer is highest in gay and bisexual men (GBM). A better understanding of the natural history of anal high-risk human papillomavirus (HRHPV) infection is needed for anal cancer prevention. Methods The Study of the Prevention of Anal Cancer was a 3-year study of Australian GBM, aged 35 years or older. We examined incidence, clearance and risk factors for 13 HRHPV types tested for at baseline and 3 annual visits. Results In 525 men with ≥ 2 visits, 348 (66.3%) acquired ≥ 1 incident HRHPV infection. HPV16 incidence rates were similar, but non-16 HRHPV incidence was higher in HIV-positive (51.8/100 person years, PY) than HIV-negative men (36.5/100 PY, p < 0.001). Annual clearance rates of HPV16 (13.21/100 PY, 95% CI 10.53-16.56) were lower than for other HRHPV types. HRHPV clearance rates were not associated with HIV overall but were significantly lower in those with a lower nadir CD4 (<200 cells/µl) for HPV16 (p=0.015) and other HRHPV types (p=0.007). Conclusion The higher incidence of non-16 HRHPV types, coupled with the lower clearance of non-16 HRHPV types in those with past impaired immune function, is consistent with the greater role of non-16 HRHPV in anal cancer in HIV-positive people.

scholarly journals Sexual transmission of hepatitis C virus among gay and bisexual men: a systematic review

Sexual Health ◽  
2017 ◽  
Vol 14 (1) ◽  
pp. 28 ◽  
Author(s):  
Fengyi Jin ◽  
Gail V. Matthews ◽  
Andrew E. Grulich
Keyword(s):  
Systematic Review ◽  
Sexual Transmission ◽  
Case Series ◽  
Gay And Bisexual Men ◽  
Injecting Drug Use ◽  
Hiv Positive ◽  
Bisexual Men ◽  
And Bisexual ◽  
Hiv Negative ◽  
Hiv Positive Men

A systematic review was performed on the evidence of sexual transmission of hepatitis C virus (HCV) in gay and bisexual men (GBM). Studies conducted in industrialised countries and published in English from 2000 to 2015 with data on HCV in GBM were included. Pooled estimates of prevalence and incidence of HCV infection were stratified by study settings and participants’ HIV status using random effect models. Case-series reports were summarised descriptively. Of the 38 cross-sectional studies, the pooled HCV prevalence was substantially higher in HIV-positive men (8.3%, 95% CI: 6.7–9.9) than in HIV-negative men (1.5%, 95% CI 0.8–2.1), and higher in those who reported injecting drug use (34.8%, 95% CI 26.9–42.7) than in those who did not (3.5%, 95% CI 2.4–4.5). Of the 16 longitudinal studies, the pooled HCV incidence was markedly higher in clinic-based (7.0 per 1000 person-years, 95% CI 4.6–9.5) than in community-based (1.4 per 1000 person-years, 95% CI 0.7–2.1) studies, and in HIV-positive men (6.4 per 1000 person-years, 95% CI 4.6–8.1) than in HIV-negative men (0.4 per 1000 person-years, 95% CI 0–0.9). Since the early 2000s, 15 case-series reports increasingly pointed to the importance of sexual transmission of HCV in mainly HIV-positive men. Injecting drug use remained the major transmission route of HCV in GBM. Receptive condomless intercourse and concurrent ulcerative sexually transmissible infections are likely drivers that facilitated HCV sexual transmission in HIV-positive men. HCV incidence remains very low in HIV-negative GBM.

Hepatitis C risk factors, attitudes and knowledge among HIV-positive, HIV-negative and HIV-untested gay and bisexual men in Australia

Sexual Health ◽  
2015 ◽  
Vol 12 (5) ◽  
pp. 411 ◽  
Author(s):  
Loren Brener ◽  
Dean A. Murphy ◽  
Elena J. Cama ◽  
Jeanne Ellard
Keyword(s):  
Risk Factors ◽  
Sexual Transmission ◽  
Gay And Bisexual Men ◽  
Hiv Positive ◽  
Bisexual Men ◽  
Hcv Transmission ◽  
Risk Practices ◽  
And Bisexual ◽  
Hcv Testing ◽  
Hiv Negative

Background There are increasing reports of sexual transmission of hepatitis C virus (HCV) among HIV-positive men who have sex with men (MSM). Still unclear is the level of HCV knowledge and the risk factors specific to HCV transmission among this population. This study compared HCV knowledge and risk practices among HIV-positive, HIV-negative and HIV-untested gay and bisexual men in Australia. Methods: Participants (n = 534) completed an online survey assessing sexual risk practices, HCV knowledge, perceived risk of acquiring HCV and perceptions of people with HCV and who inject drugs. Results: HIV-positive participants were older, reported greater engagement in sexual risk and injecting drug practices, felt they were at greater risk of acquiring HCV, were less likely to socially and sexually exclude people with HCV and had more positive attitudes towards people who inject drugs and people with HCV compared with HIV-negative and HIV-untested participants. HIV-untested participants were younger, reported fewer HCV-related serosorting practices and were more likely to socially and sexually exclude people with HCV than the other groups. Conclusions: Findings suggest that HCV education and prevention for gay men may be most effective if tailored according to HIV status. For HIV-positive men, health promotion could focus on specific sexual practices and biological factors linked to HCV transmission, regular HCV testing and better strategies for disclosure of HCV serostatus. For HIV-negative and HIV-untested men, there should be a more general focus on awareness, changing attitudes towards HCV testing and increasing general knowledge around HCV, including evidence of sexual transmission.

scholarly journals Sexual behaviours associated with incident high-risk anal human papillomavirus among gay and bisexual men

2021 ◽  
pp. sextrans-2020-054851
Author(s):  
Ian K J Wong ◽  
Isobel Mary Poynten ◽  
Alyssa Cornall ◽  
David J Templeton ◽  
Monica Molano ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Anal Cancer ◽  
Gay And Bisexual Men ◽  
Anal Intercourse ◽  
Sexual Practices ◽  
Hiv Positive ◽  
Bisexual Men ◽  
Sexual Behaviours ◽  
And Bisexual

ObjectiveHigh-risk human papillomavirus (HRHPV) causes anal cancer, which disproportionately affects gay and bisexual men (GBM). We examined sexual behaviours associated with incident anal HRHPV in an observational cohort study of GBM in Sydney, Australia.MethodsGBM aged 35 years and above were enrolled in the Study of the Prevention of Anal Cancer. Detailed information on sexual practices in the last 6 months, including receptive anal intercourse (RAI) and non-intercourse receptive anal practices, was collected. Anal human papillomavirus (HPV) testing was performed at the baseline and three annual follow-up visits. Risk factors for incident HRHPV were determined by Cox regression using the Wei-Lin-Weissfeld method.ResultsBetween 2010 and 2015, 617 men were recruited and 525 who had valid HPV results at baseline and at least one follow-up visit were included in the analysis. The median age was 49 years (IQR 43–56) and 188 (35.8%) were HIV-positive. On univariable analysis, incident anal HRHPV was associated with being HIV-positive (p<0.001), having a higher number of recent RAI partners regardless of condom use (p<0.001 for both), preference for the receptive position during anal intercourse (p=0.014) and other non-intercourse receptive anal sexual practices, including rimming, fingering and receptive use of sex toys (p<0.05 for all). In multivariable analyses, being HIV-positive (HR 1.46, 95% CI 1.09 to 1.85, p=0.009) and reporting condom-protected RAI with a higher number of sexual partners (p<0.001) remained significantly associated with incident HRHPV. When stratified by recent RAI, non-intercourse receptive anal practices were not associated with incident HRHPV in men who reported no recent RAI.ConclusionGBM living with HIV and those who reported RAI were at increased of incident anal HRHPV. Given the substantial risk of anal cancer and the difficulty in mitigating the risk of acquiring anal HRHPV, HPV vaccination should be considered among sexually active older GBM.Trial registration numberANZCTR365383.

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