Anal intraepithelial neoplasia among HIV-positive men who have sex with men

Sexual Health ◽  
2015 ◽  
Vol 12 (6) ◽  
pp. 563
Author(s):  
José A. Mata-Marín ◽  
Jorge Hernández-Figueroa ◽  
Gloria Huerta-García ◽  
Jorge Sandoval-Ramírez ◽  
Miguel Pichardo-Farfán ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
High Risk ◽  
Intraepithelial Neoplasia ◽  
Risk Groups ◽  
Hiv Positive ◽  
High Grade ◽  
Common Cause ◽  
Screening Programs ◽  
Sex With Men ◽  
Intraepithelial Lesions

Neoplasia is the second most common cause of mortality in HIV patients. The prevalence of anal cancer among men who have sex with men (MSM) has continued to increase since the introduction of antiretroviral therapy. We screened 94 HIV-infected MSM patients. We found high-grade squamous intraepithelial lesions (HSIL) in six of the patients. The calculated prevalence of HSIL was 6.4% (95% confidence interval: 2.9–13.2). The study and implementation of screening programs for high-risk groups is a priority.

Anal cytological abnormalities are poor predictors of high-grade intraepithelial neoplasia amongst HIV-positive men who have sex with men

Sexual Health ◽  
2013 ◽  
Vol 10 (1) ◽  
pp. 9 ◽  
Author(s):  
Leon P. Botes ◽  
Sarah Pett ◽  
Andrew Carr ◽  
Debbie Marriott ◽  
David A. Cooper ◽  
...  
Keyword(s):  
Intraepithelial Neoplasia ◽  
Hiv Positive ◽  
High Grade ◽  
Histological Findings ◽  
Squamous Intraepithelial Lesions ◽  
Atypical Cells ◽  
Sex With Men ◽  
Intraepithelial Lesions ◽  
General Community ◽  
Undetermined Significance

Background Although anal squamous cell carcinomas (ASCC) are rare in the general community, rates of ASCC among HIV-positive men who have sex with men (MSM) approach those of major cancers in the general community, such as colorectal and lung cancers. Anal cytology and high-resolution anoscopy (HRA) have been proposed as methods for the diagnosis of high-grade anal intraepithelial neoplasia (HGAIN), the precursor of ASCC. To determine the prevalence of anal disease among HIV-positive MSM, we investigated anal cytological and histological findings in men from a large HIV clinic in Sydney, Australia. Methods: This was a single-centre study conducted between October 2008 and January 2010. Participants self-collected cytology specimens, and those yielding abnormal cytology results of atypical cells of undetermined significance, atypical cells of undetermined significance – possibly high-grade (ASC-H) and high-grade squamous intraepithelial lesions (HSIL) were offered HRA. In addition, of those yielding low-grade squamous intraepithelial lesions results, a systematically selected group (25%) were offered HRA. Results: Of the 1339 HIV-positive MSM who attended the clinic during the study period, 291 (31.8%) were finally included in the study, 262 yielded technically satisfactory cytological results and 101 (36.7%) participants underwent HRA. HGAIN was identified in 55 (54.5%) of the 101 men undergoing HRA. HGAIN was diagnosed in 28 (52.7%) without cytological ASC-H or HSIL results. Conclusions: Despite the poor correlation between anal cytological and histological findings, high levels of HGAIN were identified in HIV-positive MSM attending this clinical service.

scholarly journals Determinants of high-grade anal intraepithelial lesions in HIV-positive men having sex with men

2018 ◽  
Vol 5 ◽  
pp. S3
Author(s):  
Isabelle Etienney ◽  
Laurent Siproudhis ◽  
Lionel Piroth ◽  
Isabelle Poizot-Martin ◽  
Sylvie Radenne ◽  
...  
Keyword(s):  
Hiv Positive ◽  
High Grade ◽  
Sex With Men ◽  
Intraepithelial Lesions ◽  
Hiv Positive Men

Prevalence and predictors of high-grade anal intraepithelial neoplasia in a community-based sample of homosexual men

Sexual Health ◽  
2012 ◽  
Vol 9 (6) ◽  
pp. 574 ◽  
Author(s):  
Richard J. Hillman ◽  
Marina T. van Leeuwen ◽  
Claire M. Vajdic ◽  
Leo McHugh ◽  
Garrett P. Prestage ◽  
...  
Keyword(s):  
High Risk ◽  
Intraepithelial Neoplasia ◽  
Anal Intraepithelial Neoplasia ◽  
Hiv Positive ◽  
Homosexual Men ◽  
High Grade ◽  
Community Based ◽  
Cytological Abnormalities ◽  
Hiv Negative ◽  
Hiv Positive Men

Background We report the prevalence and predictors for high-grade anal intraepithelial neoplasia (HGAIN) in community-based cohorts of HIV-negative and HIV-positive homosexual men in Sydney, Australia. Methods: A cross-sectional study of consecutive participants in both cohorts was performed in 2005 (204 HIV-negative and 128 HIV-positive men). Anal swabs collected by a research nurse underwent cytological analysis, using the ThinPrep procedure, and human papillomavirus (HPV) testing. Participants who had cytological abnormalities other than low-grade squamous epithelial lesions (SIL) were referred for high resolution anoscopy (HRA). Results: A total of 114 men had cytological abnormalities (24.3% of HIV-negative and 57.5% of HIV-positive men, odds ratio (OR) = 4.21, 95% confidence interval (CI) 2.57–6.90). However, only three (2.3%) HIV-positive men and no HIV-negative men had high-grade SIL on anal cytology. Seventy-seven men were referred for HRA, of whom 63 (81.8%) attended. Histologically confirmed HGAIN was detected in 21 (33.3%). The prevalence of HGAIN was higher in HIV-positive men (10.8%) than in HIV-negative men (5.0%, OR = 2.29, 95% CI 0.93–5.63, P = 0.071). HGAIN was not related to age but was strongly associated with the detection of high-risk types of anal HPV (OR = 10.1, 95% CI 1.33–76.2) rather than low-risk types (OR = 1.97, 95% CI 0.74–5.25). Conclusion: HGAIN was prevalent in homosexual men across all age groups and was more than twice as common in HIV-positive men compared with HIV-negative men. The presence of high-risk anal HPV was highly predictive of HGAIN.

Progression From Perianal High-Grade Anal Intraepithelial Neoplasia to Anal Cancer in HIV-Positive Men Who Have Sex With Men

2016 ◽  
Vol 59 (9) ◽  
pp. 836-842 ◽  
Author(s):  
Jill Tinmouth ◽  
Valentina Peeva ◽  
Henok Amare ◽  
Sandra Blitz ◽  
Janet Raboud ◽  
...  
Keyword(s):  
Anal Cancer ◽  
Intraepithelial Neoplasia ◽  
Anal Intraepithelial Neoplasia ◽  
Hiv Positive ◽  
High Grade ◽  
Sex With Men ◽  
Hiv Positive Men

scholarly journals Incidence of cervical high-grade squamous intraepithelial lesions in HIV-1-infected women with no history of cervical pathology: up to 17 years of follow-up

2018 ◽  
Vol 30 (1) ◽  
pp. 56-63 ◽  
Author(s):  
Sebastián Videla ◽  
Antoni Tarrats ◽  
Arelly Ornelas ◽  
Roger Badia ◽  
Eva Castella ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
High Risk ◽  
Hpv Infection ◽  
High Grade ◽  
Papanicolaou Smear ◽  
Papanicolaou Smears ◽  
High Risk Hpv ◽  
Intraepithelial Lesions ◽  
Hiv 1

Currently, Papanicolaou smears are proposed at three-year intervals for cervical screening to all women living with HIV. The aim of this retrospective cohort study was to provide data on the incidence of cervical high-grade squamous intraepithelial lesions (HSIL) in cervical smear confirmed by histology in HIV-1-infected women (two consecutive normal Papanicolaou smears at baseline) after a long-term follow-up. Sixty-seven women (recruited between March 1999 and January 2003) were analyzed. The median period of follow-up was 13.2 years (range: 7.4–17.1 years) with a total of 583 Papanicolaou smears. Twenty-seven percent of these HIV-1-infected women had poorly-controlled HIV. Cumulative incidence of HSIL was 18% (12/67; 95%CI: 11–29%) of which one was an invasive squamous cell carcinoma and two were carcinoma in situ. These women had not been well-engaged with the annual Papanicolaou smear screening program and had poor adherence to antiretroviral therapy. Development of HSIL was associated with high-risk-HPV infection (OR: 14.9; 95%CI: 3.0, 75.1). At last Papanicolaou smear, prevalence of high-risk-HPV infection was 30% (20/66, 95%CI: 21–42%). In conclusion, the incidence of cervical HSIL in HIV-1-infected women with poor antiretroviral therapy adherence or poor immunological status reinforces the need to identify those HIV-1-infected women at risk of developing cervical cancer.

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