Models of cervical screening in the era of human papillomavirus vaccination

Sexual Health ◽  
2010 ◽  
Vol 7 (3) ◽  
pp. 359 ◽  
Author(s):  
Karen Canfell
Keyword(s):  
Human Papillomavirus ◽  
Screening Program ◽  
Cervical Screening ◽  
Age Groups ◽  
Simulation Modelling ◽  
Term Effect ◽  
Short Term ◽  
Human Papillomavirus Vaccination ◽  
Long Term Effect

Epidemiologic and economic evaluation using simulation modelling can support complex policy decisions, and is an important tool in predicting the future interaction between human papillomavirus vaccination and cervical screening. Several categories of screening program evaluation are of interest, including: (1) changes to screening considered over the short term, over which the effects of vaccination should be confined to the youngest age groups (<30 years old); (2) the medium and long-term effect of vaccination on the screening program; and (3) changes to screening in context of vaccination. This review considers some of the policy questions in each category and discusses the modelling implications, with particular focus on the Australian context.

Cytology and cervical cancer surveillance in an era of human papillomavirus vaccination

Sexual Health ◽  
2010 ◽  
Vol 7 (3) ◽  
pp. 328 ◽  
Author(s):  
Alison C. Budd ◽  
Christine J. Sturrock
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Hpv Vaccine ◽  
Screening Program ◽  
Cervical Screening ◽  
Cancer Surveillance ◽  
Human Papillomavirus Vaccination ◽  
Incidence Data ◽  
National Monitoring

Cytological and cancer surveillance will provide the most effective indications of short-term effects and long-term outcomes of the introduction of the human papillomavirus (HPV) vaccine in Australia. This article outlines how this surveillance is proposed to occur through the established national monitoring mechanisms of the National Cervical Screening Program in the annual Australian Institute of Health and Welfare (AIHW) publication ‘Cervical screening in Australia’. Cytological surveillance will be possible principally through cytology data provided annually by the state and territory cervical cytology registers, and it is expected that these data will provide the earliest and most comprehensive indications of effects from the HPV vaccine. Some potential issues in interpreting these data are also discussed, including the potentially confounding effects of the introduction of new National Health and Medical Research Council guidelines ‘Screening to prevent cervical cancer: guidelines for the management of asymptomatic women with screen-detected abnormalities’ some 9 months before the introduction of the vaccine. Cancer surveillance over the long term will be possible using cervical cancer incidence data reported annually for the National Cervical Screening Program in ‘Cervical screening in Australia’ using data sourced from the Australian Cancer Database. In a final discourse, the HPV vaccine and cervical screening are discussed concurrently, and the importance of continued cervical screening in the HPV vaccine era emphasised.

scholarly journals Controlled trial of the short- and long-term effect of psychological treatment of post-partum depression

2003 ◽  
Vol 182 (5) ◽  
pp. 412-419 ◽  
Author(s):  
Peter J. Cooper ◽  
Lynne Murray ◽  
Anji Wilson ◽  
Helena Romaniuk
Keyword(s):  
Primary Care ◽  
Postnatal Depression ◽  
Post Partum ◽  
Psychodynamic Therapy ◽  
Term Effect ◽  
Short Term ◽  
Post Partum Depression ◽  
Maternal Mood ◽  
Long Term Effect

BackgroundPsychological interventions for postnatal depression can be beneficial in the short term but their longer-term impact is unknown.AimsTo evaluate the long-term effect on maternal mood of three psychological treatments in relation to routine primary care.MethodWomen with post-partum depression (n=193) were assigned randomly to one of four conditions: routine primary care, non-directive counselling, cognitive–behavioural therapy or psychodynamic therapy. They were assessed immediately after the treatment phase (at 4.5 months) and at 9, 18 and 60 months post-partum.ResultsCompared with the control, all three treatments had a significant impact at 4.5 months on maternal mood (Edinburgh Postnatal Depression Scale, EPDS). Only psychodynamic therapy produced a rate of reduction in depression (Structured Clinical Interview for DSM–III–R) significantly superior to that of the control. The benefit of treatment was no longer apparent by 9 months post-partum. Treatment did not reduce subsequent episodes of post-partum depression.ConclusionsPsychological intervention for post-partum depression improves maternal mood (EPDS) in the short term. However, this benefit is not superior to spontaneous remission in the long term.

A comparison of the effects of body condition and short-term food restriction on the feeding behaviour of sheep

1996 ◽  
Vol 1996 ◽  
pp. 174-174
Author(s):  
A.M. Sibbald
Keyword(s):  
Food Intake ◽  
Body Condition ◽  
Feeding Behaviour ◽  
Food Restriction ◽  
Term Effect ◽  
Short Term ◽  
Daily Food ◽  
Long Term Effect ◽  
Single Meal

Voluntary food intake is generally inversely related to body condition or fatness in mature sheep (Foot, 1972). Since the intake of pelleted diets by housed sheep consists of a number of discrete feeding bouts or 'meals' (e.g. Bermudez et al., 1989), the relatively long-term effect of body condition on intake will be achieved through changes in feeding behaviour at the level of a single meal. The aim of this experiment was to compare the effects of body condition and short-term food restriction on meal patterns in sheep, to investigate the mechanism by which body condition influences daily food intake.

Brassinosteroid-induced de-etiolation of Arabidopsis thaliana seedlings resembles the long-term effects of cytokinins

1998 ◽  
Vol 25 (6) ◽  
pp. 719 ◽  
Author(s):  
Jie Luo ◽  
Ji-Chu Chen ◽  
Yu-Ju Zhao
Keyword(s):  
Arabidopsis Thaliana ◽  
Term Effect ◽  
Hypocotyl Elongation ◽  
Long Term Effects ◽  
Short Term ◽  
Expression Of Genes ◽  
Long Term Effect ◽  
In The Wild ◽  
Positive Regulators

Cytokinins can cause de-etiolation of Arabidopsis thaliana (L.) Heynh. seedlings growing in the dark. Brassinosteroids (BRs) have been considered to regulate negatively the de-etiolation in dark-grown Arabidopsis seedlings. We show here that epi-brassinolide (epi-BL) can partially produce the phenotype of de-etiolation as caused by treatment with cytokinins in the dark, including the development of leaves and epicotyls in the wild-type and the BR-deficient mutant det2. But BRs cannot inhibit hypocotyl elongation, nor restore all the inhibition caused by cytokinins and light. We have found that there are distinct short term and long term phases of induction of de-etiolation by cytokinins. The short-term effect is probably coupled to ethylene in the inhibition of the hypocotyl elongation; the long-term effect causes morphogenesis of leaves and epicotyls. BRs can only regulate de-etiolation in the long term. We propose that the inhibition of hypocotyl elongation of det2 in darkness is caused by the absence of BR-dependent elongation rather than the inhibition caused by the expression of genes for photomorphogenesis. We propose that BRs resemble cytokinins in regulating de-etiolation as positive regulators, and that the inhibition of hypocotyl elongation and the development of leaves and epicotyls in de-etiolation are independent processes.

Long-term regulation of hexose uptake by isoproterenol in cultured 3T3 adipocytes

1985 ◽  
Vol 248 (6) ◽  
pp. E706-E711 ◽  
Author(s):  
J. P. van Putten ◽  
H. M. Krans
Keyword(s):  
Protein Synthesis ◽  
Prolonged Exposure ◽  
Term Effect ◽  
Long Term Effects ◽  
Fat Cell ◽  
Short Term ◽  
Long Term Effect ◽  
Short Term Exposure ◽  
Hexose Uptake

Catecholamines are known to have short-term regulatory effects on fat cell hexose uptake. We examined the long-term effects of catecholamines on the insulin-sensitive 2-deoxyglucose (dGlc) uptake in cultured 3T3-L1 adipocytes. Prolonged exposure (48 h) to isoproterenol (beta-adrenergic agonist) stimulated the basal dGlc uptake up to 90%. The effect was specific, time, concentration, and protein synthesis dependent and reversible. The effect of insulin was unaltered and superimposed on the increase in basal dGlc uptake. The long-term effect of isoproterenol was mimicked by epinephrine, dibutyryl cAMP (DBcAMP), and 1-methyl-3-isobutylxanthine (IBMX). By contrast, short-term exposure to isoproterenol (and epinephrine) induced a protein synthesis-independent increase in basal dGlc uptake (30%) not accompanied by an increase in insulin responsiveness. Moreover, on short-term basis, DBcAMP and IBMX suppressed both the basal and insulin-stimulated uptake up to 50%. Determination of the intracellular nonphosphorylated dGlc during the uptake and of the hexokinase activity revealed that the long-term effect of isoproterenol was most likely due to alterations low in dGlc transport. In conclusion, long-term regulators of hexose uptake are in cultured 3T3-L1 adipocytes, isoproterenol, and other cAMP stimulators. The long-term effect is independent from the short-term regulatory effect of the agents and from the effect of insulin.

scholarly journals Sensibility of Children of Different Age Groups to Alarm Intervention for Enuresis

2015 ◽  
Vol 35 (1) ◽  
pp. 49-56 ◽  
Author(s):  
KV Kosilov ◽  
SA Loparev ◽  
MA Ivanovskaya ◽  
LV Kosilova
Keyword(s):  
Nocturnal Enuresis ◽  
Age Groups ◽  
Term Effect ◽  
Random Numbers ◽  
Treatment Control ◽  
Optimal Response ◽  
Long Term Effect ◽  
High Age ◽  
The Difference

Introduction: Prevalence of primary monosymptomatic night enuresis (PMNE) is high. Age, gender and race of patients, as well as diagnostics criteria used by the researchers, have an impact on the data on enuresis prevalence, and alarm intervention has been used for enuresis treatment for several decades The purpose of this study is to try to find out the difference in efficiency of the Alarm intervention for children of different age for improving recommendations on usage of alarm systems.Materials and Methods: Sampling consisted of 399 persons: 238 males and 161 females suffering PMNE. A method of random numbers was used for group randomization. Persons of both genders at the age of 7 to 15 years old having at least two episodes of nocturnal enuresis per week were included into the treatment group. Then they were distributed into three subgroups where questionnaires were filled, uro-flowmetry and investigations were done Treatment control was carried out with the help of bladder diaries where episodes of nocturnal, spontaneous awakenings in case of desire to urinate and dry nights were registered. Alarm intervention was conducted by standard method with the use of device Wet Stop/ BYE-WET by PALCO LABS, Inc (USA).Results: Initial data showed that children of junior and average age subgroups show optimal response to conducted therapy. However, the results of 10-12-yearold children proved to be stable, the result of 7-9-year-old children was significantly worse in two months after the end of treatment.Conclusion: Alarm intervention has the best direct and long-term effect on 10-12-year old children.J Nepal Paediatr Soc 2015;35(1):49-56

The short‐term and the long‐term effect of primary schools and classes on mathematics and language achievement scores

2007 ◽  
Vol 33 (3) ◽  
pp. 419-440 ◽  
Author(s):  
Heidi Pustjens ◽  
Eva Van de gaer ◽  
Jan Van Damme ◽  
Patrick Onghena ◽  
Georges Van Landeghem
Keyword(s):  
Primary Schools ◽  
Term Effect ◽  
Achievement Scores ◽  
Language Achievement ◽  
Short Term ◽  
Long Term Effect
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