Sexual dysfunction in men treated with depot antipsychotic drugs: a pilot study

Sexual Health ◽  
2007 ◽  
Vol 4 (4) ◽  
pp. 269 ◽  
Author(s):  
David Plevin ◽  
Cherrie Galletly ◽  
Penny Roughan
Keyword(s):  
Sexual Dysfunction ◽  
Sexual Function ◽  
Antipsychotic Drugs ◽  
Elevated Serum ◽  
Serum Testosterone ◽  
Chronic Schizophrenia ◽  
Structured Interview ◽  
Drug Dose ◽  
Serum Prolactin ◽  
Long Acting

Background: Sexual dysfunction is common, but often under-recognised, in people with schizophrenia. Many antipsychotic drugs are known to cause prolactin elevation, and it is often assumed that sexual dysfunction is a consequence of prolactin elevation. We investigated the relationship between sexual function and serum concentrations of prolactin and testosterone in men receiving regular long-acting depot injections of antipsychotic medication. Methods: Twenty-two men attending a community depot clinic participated. A structured interview was used to collect information about sexual function, and serum prolactin and testosterone concentrations were measured. Results: Sexual dysfunction was common, with 73% of men reporting problems in at least one area of sexual function. Six men had elevated serum prolactin and one had reduced serum testosterone. Antipsychotic drug dose was positively correlated with serum prolactin and negatively correlated with serum testosterone, but there was no association between serum prolactin or testosterone concentrations and any measure of sexual dysfunction. Conclusion: Sexual dysfunction is a major problem for men living with chronic schizophrenia, but our results suggest that it is not directly attributable to elevated prolactin or reduced testosterone concentrations.

scholarly journals Stimulation of a non-functioning pituitary macroadenoma after administration of goserelin acetate for locally advanced prostate cancer causing a sustained elevation in PSA and testosterone

2013 ◽  
Vol 6 (2) ◽  
Author(s):  
Fady R. Youssef ◽  
Robert T. Robinson ◽  
Nigel R. Boucher
Keyword(s):  
Prostate Cancer ◽  
Advanced Prostate Cancer ◽  
Locally Advanced ◽  
Elevated Serum ◽  
Serum Testosterone ◽  
Androgen Deprivation ◽  
Alternative Methods ◽  
Pituitary Macroadenoma ◽  
Locally Advanced Prostate Cancer ◽  
Long Acting

Long-acting luteinizing hormone-releasing hormone (LHRH) agonists, such as goserelin, have been used for locally advanced and metastatic prostate cancer for many years and are the main forms of androgen deprivation therapy (ADT). Acting on pituitary LHRH receptors, they initially stimulate a transient rise in serum follicle stimulating hormone (FSH) and LH. Long-term administration of an LHRH analogue will eventually lead to down regulation of LHRH receptors, thus suppressing FSH and LH secretion. This in turn suppresses testosterone production hence achieving and maintaining androgen deprivation. This case highlights the potential anomaly of a sustained elevated serum testosterone in the context of newly diagnosed locally advanced prostate cancer with a co-existing pituitary macroadenoma after administration of LHRH analogues. Alternative methods of androgen deprivation must be considered in such patients.

Sexual behavior in psychiatric patients: a review

2015 ◽  
Vol 3 (2) ◽  
pp. 378-388
Keyword(s):  
Sexual Behavior ◽  
Sexual Dysfunction ◽  
Psychiatric Disorder ◽  
Sexual Function ◽  
Antipsychotic Drugs ◽  
Psychotic Disorders ◽  
Psychiatric Patients ◽  
Normal Population ◽  
Relational Factors ◽  
Natural Component

Sexuality is a natural component of human behavior, and the nature of sexual behavior in the normal population has been well addressed. Further interplay of multiple facets, including anatomical, physiological, psychological, developmental, cultural, and relational factors. Sexual dysfunction is common in people with Psychiatric disorder e.g. schizophrenia and other psychotic disorders, and it are known to affect all domains of sexual function including desire, arousal, erection, ejaculation and orgasm. Furthermore, antipsychotic drugs are associated with sexual dysfunction with unclear mechanisms. This article will review the literatures on the psychiatric sexual behavior in focusing on prevalence, etiology, and treatment.

scholarly journals Problems with the Administration of Antipsychotic Drugs in Depot Formulations in the Treatment of Schizophrenia

2018 ◽  
Vol 35 (1) ◽  
pp. 65-72 ◽  
Author(s):  
Anica Ranković ◽  
Slobodan Janković
Keyword(s):  
Severe Pain ◽  
Antipsychotic Drugs ◽  
Structured Interview ◽  
Not Given ◽  
Treatment Burden ◽  
Depot Injection ◽  
History Of ◽  
Long Acting ◽  
Needle Diameter ◽  
And Training

Summary The aim of this study was to investigate problems with the administration of antipsychotic long-acting injections (LAIs) in patients with schizophrenia. Besides many benefits, long-acting injections have been associated with a number of complications at the site of the injection. The qualitative study included four medical workers and five patients who had been treated with fluphenazine, haloperidol, risperidone given in the form of a long-acting depot injection. The data were collected by direct observation, analysis of the history of the disease and used semi-structured interview. Interviews completed by patients, psychiatrists and nurses were analyzed and condensed into nine key categories: Competence and training of the medical workers, Sites and technique, Registration of complications, Care of patients and privacy, Availability and evidence, Duration and frequency of treatment, Burden for the patients, The choice of formulation therapy, and Sense of stigma. Monitoring of side-effects of LAIs was not extensive and doctors did not write adverse effects. The nurses who administered the injections were competent. Not enough attention is paid to the choice of the needle diameter and the patient was not given a choice to decide on the sites of the administraton of injection. Three out of five patients did not feel any changes at the injection site, but another patient had severe pain, redness, and induration. The exchange of information, a possibility of choosing the site of administration, and monitoring of the effects of treatment are all positive strategies that doctors and nurses can use to help patients in the compliance to the treatment with antipsychotic long-acting injections.

scholarly journals Sexual side-effects of antidepressant and antipsychotic drugs

2003 ◽  
Vol 9 (3) ◽  
pp. 202-210 ◽  
Author(s):  
David Baldwin ◽  
Andrew Mayers
Keyword(s):  
Side Effects ◽  
Sexual Dysfunction ◽  
Adverse Effects ◽  
Sexual Function ◽  
Psychotropic Drugs ◽  
Antipsychotic Drugs ◽  
Well Being ◽  
Sexual Expression ◽  
Human Relationships ◽  
Sexual Side Effects

Adequate sexual expression is essential to many human relationships and provides a sense of physical, psychological and social well-being. Epidemiological and clinical studies show that depression and schizophrenia are associated with impairment of sexual function and satisfaction, even in untreated patients. Most antidepressant and antipsychotic drugs have adverse sexual effects but it is difficult accurately to identify the incidence of treatment-emergent dysfunction, as disturbances can be reliably detected only from systematic enquiries made at baseline and during treatment. Growing awareness of the adverse effects of psychotropic drugs has led to attempts to use adjuvants or substitute treatments to resolve sexual dysfunction. More studies of the effects of antidepressant and antipsychotic drugs on sexual function are needed.

scholarly journals Sexual Dysfunction and its Determinants in Male Patients with Rheumatoid Arthritis

2021 ◽  
Vol 9 (B) ◽  
pp. 350-355
Author(s):  
Hassan O. Ghareeb ◽  
Ghada M. Khafagy ◽  
Hatem H. Eleishi ◽  
Hala A. Hussein ◽  
Marwa D. Hasan
Keyword(s):  
Quality Of Life ◽  
Rheumatoid Arthritis ◽  
Sexual Dysfunction ◽  
Sexual Function ◽  
Disease Activity ◽  
Serum Testosterone ◽  
Sexual Problems ◽  
Psychological State ◽  
Male Patients

BACKGROUND: Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease affects about 0.5–1% of adults. Sexuality is an integral part of human quality of life and responsible for our individual welfare, study the association between them is highly important as many studies revealed that sexuality is greatly affected in RA patients. AIM: This study aims to determine the possible different risk factors for sexual dysfunction (SD) in RA and to study the magnitude of SD among RA male patients. METHODS: This is a case–control study carried on 60 males – aged between 18–45 years – attending Family Medicine and Rheumatology Clinic in Kasr Alainy, Cairo University, Egypt. Participants were divided into case and control groups, both groups were matched regarding socioeconomic status. All participants were evaluated for sexual function using international index of erectile function (IIEF), psychological state using patient health questionnaire (PHQ9), disease-related disability using health assessment questionnaire, disease severity using disease activity score 28, and serum testosterone level was assessed. RESULTS: There was a statistically significant difference between both groups regarding IIEF (OR o’s SD among patients were 1.66), PHQ9, and serum testosterone (p = 0.005). There was highly statistically significant negative correlation between sexual problems and depression, disease caused disability, RA duration and there was highly statistically significant positive correlation between sexual problems and serum hormonal level. CONCLUSION: Sexual problems are a prominent problem in males who suffer from RA. Sexual function was significant associated with disease activity, depression, quality of life, and with lower levels of total and free testosterone.

Ventrolateral Preoptic Nucleus of Hypothalamus: A Possible Target for Deep Brain Stimulation for Treating Sexual Dysfunction

2020 ◽  
Vol 5 (3 And 4) ◽  
pp. 99-102
Author(s):  
Fariborz Ghaffarpasand ◽  
◽  
Mousa Taghipour ◽  
Keyword(s):  
Deep Brain Stimulation ◽  
Sexual Dysfunction ◽  
Sexual Function ◽  
Brain Stimulation ◽  
Sexual Behaviors ◽  
Angular Gyrus ◽  
Parahippocampal Gyrus ◽  
Left Caudate ◽  
Ventrolateral Preoptic Nucleus ◽  
Deep Brain

Sexual function and orientation is a complex platform of human personality which is being modulated by several brain circuities which is less understood currently. Recently, several studies have demonstrated interesting results regarding the role of several brain locations in sexual behaviors and orientation. Sexual arousal in homosexual men is associated with activation of the left angular gyrus, left caudate nucleus, Ventrolateral Preoptic (VLPO) Nucleus of Hypothalamus and right pallidum; while it is associated with bilateral lingual gyrus, right hippocampus, and right parahippocampal gyrus in heterosexual men. We postulate that sexual-orientation behaviors are being mediated by several circuits in the brain in the center of which the VLPO is playing an indistinguishable role. We hypothesize that the different aspects of the sexual dysfunction could be associated with innate or acquired lesions of VLPO. Accordingly, the electrical stimulation of the nucleus in those with sexual dysfunction would be a treatment option. Thus the VLPO could be considered a target for Deep Brain Stimulation (DBS) in individuals with impaired sexual function.

The Novel Antipsychotic Drug Cariprazine and Cognition Enhancing Drugs: Indications for Their Use as an Add-on Therapy in Schizophrenia

2020 ◽  
Vol 26 ◽  
Author(s):  
Felix-Martin Werner ◽  
Rafael Coveñas
Keyword(s):  
Clinical Trials ◽  
Maintenance Therapy ◽  
Antipsychotic Drug ◽  
Cognitive Functions ◽  
Antipsychotic Drugs ◽  
Psychotic Disorders ◽  
Therapeutic Effects ◽  
Treatment Resistant ◽  
Long Acting ◽  
Novel Antipsychotic

Background: Schizophrenia and schizoaffective disorder are treated with antipsychotic drugs. Some patients show treatment-resistant forms of psychotic disorders and, in this case, they can be treated with clozapine. In these patients and based on previous reviews on novel antipsychotic drugs, it is important to know whether an add-on therapy with new drugs can ameliorate the positive and negative schizophrenic scale (PANSS) total score. Objective: The aim of this review is to suggest an appropriate treatment for patients with treatment-resistant forms of psychotic disorders. A combination of current available antipsychotic drugs with novel antipsychotic or modulating drugs might improve negative schizophrenic symptoms and cognitive function and thereby social functioning and quality of life. Results: The mechanisms of action, the therapeutic effects and the pharmacokinetic profiles of novel antipsychotic drugs such as cariprazine, brexipiprazole and lumateperone are up-dated. Published case reports of patients with treatmentresistant psychoses are also discussed. These patients were treated with clozapine but a high PANSS total score was observed. Only an add-on therapy with cariprazine improved the score and, above all, negative schizophrenic symptoms and cognitive functions. To ensure a constant antipsychotic drug concentration, long-acting injectable antipsychotic drugs may be a choice for a maintenance therapy in schizophrenia. New modulating drugs, such as receptor positive allosteric modulators (N-methyl-D-aspartate receptor; subtype 5 of the metabotropic glutamatergic receptor) and encenicline, an alpha7 nicotinic cholinergic receptor agonist, are being investigated in preclinical and clinical trials. Conclusion: In clinical trials, patients with treatment-resistant forms of psychosis should be examined to know whether a combination therapy with clozapine and a novel antipsychotic drug can ameliorate the PANSS total score. In schizophrenia, long-acting injectable antipsychotic drugs are a safe and tolerable maintenance therapy. In further clinical studies, it should be investigated whether patients with treatment-resistant forms of psychoses can improve negative schizophrenic symptoms and cognitive functions by an add-on therapy with cognition enhancing drugs.

Sign in / Sign up

Export Citation Format

Share Document