197 The Effect of Gonadotropin-Releasing Hormone Agonist on Superovulation and Estrous Synchronization in Female Sprague Dawley Rat

2018 ◽  
Vol 30 (1) ◽  
pp. 239
Author(s):  
Y.-K. Jin ◽  
H.-S. Bae ◽  
J.-Y. Lee ◽  
S.-Y. Yum ◽  
K.-M. Kim ◽  
...  
Keyword(s):  
Gonadotropin Releasing Hormone ◽  
Oestrous Cycle ◽  
Control Group ◽  
Sprague Dawley ◽  
Releasing Hormone ◽  
Estrous Synchronization ◽  
Injection Group ◽  
Significant Difference ◽  
The Difference ◽  
Set Up

A large number of oocytes and adequate recipient conditions are required to produce genetically modified rats by embryo transfer. In this study, we investigated the effect of a synthetic gonadotropin-releasing hormone (GnRH) agonist, buserelin, on (1) superovulatory response in donor rats, and (2) oestrous cycle synchrony in recipient female Sprague Dawley rats at 8 weeks of age. First, for superovulation, donors were divided into 2 groups: control and buserelin injection group (42 μg mL−1). Superovulation was performed in both groups by injection of pregnant mare’s serum gonadotropin (PMSG, 150 IU) at Day −3 and human chorionic gonadotropin (hCG, 150 IU) at Day −1 (Day 0 = oocyte collection). In addition, the buserelin group was given 42 μg mL−1 buserelin on Day −4. Oviduct and ampulla were removed surgically to collect the oocytes. As results, more ovulations were detected in the 42 μg mL−1 buserelin group (6.18 ± 1.10 oocyte/rat, n = 240) than in the control group (5.06 ± 0.82 oocyte/rat; n = 124; t-test P = 0.038). Second, 2 groups were set up to investigate the effect of administration of buserelin on synchronizing the oestrus cycle of recipients. Because the oestrous cycle of the rat was 4 to 5 days, we examined the difference of vaginal impedance between the 2 groups on Day 4 after injection and checked whether there was a significant difference in the synchronization of the oestrous cycle. An impedance value >3.0 kΩ was considered as an indication for proestrus stage; therefore, we analysed the data >3.0 kΩ in both groups. In results, the incidence of proestrus was significantly increased in buserelin injection group (n = 128) than in the control group (n = 70). In addition, there was a significant difference in mean impedance in the 2 groups (buserelin injection group: 4.25 ± 3.79 kΩ; control group: 1.43 ± 1.20 kΩ; P < 0.005). In conclusion, administration of 42 μg mL−1 buserelin had a beneficial effect on oocyte ovulation and oestrous synchronization, and it will be usefully applied in the production of transgenic rats.

252 EFFECT OF SUPERSTIMULATORY TREATMENT TO DONOR COWS IN OXYGEN CONSUMPTION OF MATURED OOCYTES

2013 ◽  
Vol 25 (1) ◽  
pp. 273
Author(s):  
K. Imai ◽  
S. Sugimura ◽  
M. Ohtake ◽  
Y. Aikawa ◽  
Y. Inaba ◽  
...  
Keyword(s):  
Oxygen Consumption ◽  
Prostaglandin F2α ◽  
Gonadotropin Releasing Hormone ◽  
Oestrous Cycle ◽  
Control Group ◽  
Releasing Hormone ◽  
And Control ◽  
Bovine Oocytes

We previously reported that follicular wave synchronization and follicular growth treatment (FGT) before ovum pick-up (OPU) were effective in improving oocyte competence, which was associated with an increase in related embryos obtained by somatic cell nuclear transfer (Sugimura et al. 2012 Cell. Reprogram. 14, 29–37). However, oxygen consumption in oocytes remained unknown. The present study was designed to examine the differences in oxygen consumption between bovine oocytes obtained by OPU with or without FGT after in vitro maturation. Holstein dry cows (n = 8) were reared under the same feeding and environmental conditions. Two OPU sessions were conducted in each cow to collect immature oocytes, as described by Sugimura et al. (2012). The first OPU session (OPU group) was performed in cows on arbitrary days of the oestrous cycle, using a 7.5-MHz linear transducer with the needle connected to an ultrasound scanner. Follicles larger than 8 mm in diameter were then aspirated and a controlled internal drug release device (CIDR) was inserted on Day 5 (the day of the first OPU session = Day 0). Then 30 Armour units (AU) of FSH (Antrin, Kyoritsu Seiyaku, Tokyo, Japan) was administrated to cows twice a day from Day 7 to 10 in decreasing doses (6, 6, 4, 4, 3, 3, 2, 2 AU day–1). Cloprostenol (prostaglandin F2α; 0.75 mg) was administered in the morning of Day 9. The second OPU session (FGT-OPU group) was performed 48 h after prostaglandin F2α administration (Day 11), and only follicles larger than 5 mm in diameter were aspirated. The CIDR was removed from the cows just before OPU. Collected cumulus–oocyte complexes in the OPU and FGT-OPU groups were matured in vitro as described by Imai et al. [2006 J. Reprod. Dev. 52(Suppl.), S19–S29]. To collect in vivo-matured oocytes (control group), the CIDR was inserted into the cows on arbitrary days of the oestrous cycle (= Day 0), and oestradiol benzoate (0.8 mg) was administered on Day 1. The cows received the FGT treatment (as described above) from Day 6 to 10; however, the CIDR was removed in the evening of Day 8. Buserelin (gonadotropin-releasing hormone; 200 µg) was then administrated in the morning of Day 10, and OPU was performed at 24 h after gonadotropin-releasing hormone administration (Day 11). Oxygen consumption of matured oocytes was measured noninvasively with a scanning electron microscopy system (HV-405SP; Hokuto Denko Co., Tokyo, Japan). Data were analysed by ANOVA followed by a Tukey-Kramer test. There was no difference in the mean oxygen consumption between the FGT-OPU group (0.34 ± 0.02 × 10–14 mol–1, mean ± SEM) and control group (0.40 ± 0.01 × 10–14 mol–1). However, oxygen consumption in the FGT-OPU and control groups was significantly lower (P < 0.01) than that in the OPU group (0.50 ± 0.02 × 10–14 mol–1). These results revealed significantly lower oxygen consumption in OPU-derived in vitro-matured bovine oocytes after FGT treatment compared with those obtained without FGT treatment. Oxygen consumption of oocytes obtained from FGT-OPU was similar to that of in vivo-matured oocytes, which may reflect their cytoplasmic maturation status with high developmental competence.

scholarly journals Effects of Different Estrous Synchronization Methods on the Composition of Simmental Cow’s Milk

2017 ◽  
Vol 45 (1) ◽  
pp. 7 ◽  
Author(s):  
Ibrahim Seker ◽  
Ali Risvanli ◽  
Mehmet Calicioglu ◽  
Gokhan Kursad Incili ◽  
Nevzat Saat
Keyword(s):  
Dairy Cattle ◽  
Milk Fat ◽  
Management Practices ◽  
Primary Objective ◽  
Control Group ◽  
Lactation Period ◽  
Estrous Synchronization ◽  
Milk Samples ◽  
Significant Difference ◽  
The Difference

Background: Estrous synchronization is one of the primary applications performed to improve the fertility and to consolidate the parturition times in dairy cattle farms. Since the primary objective is to increase fertility regardless of the method of synchronization used, the effect of this process on the udder health and the quality of milk is generally ignored. Therefore, in the present study, the aim was to investigate the effect of different estrous synchronization methods t on the milk quality in a dairy cattle farm.Materials, Methods & Results: In this study, a total of 100 Simmental cows the same farm under good management practices were used. The animals were randomly divided into 4 groups of 25 cows each. The animals in the 1st group were used as a control group without any treatment. Progesterone-releasing intravaginal device (PRID) was inserted to the animals in the 2nd group, double dose of prostaglandin F2 alpha (PGF2-alpha) with 11 days apart was applied to the animals in the 3rd group, and the Ovsynch protocol was applied to the animals in the 4th group. Starting from the first day of the applications, milk samples from each milk tank belonging to the groups were taken, kept frozen for 3 months and analyzed for the levels of fat, nonfat solids, density, protein, lactose and minerals over the course of one month. According to the results, the minimum milk fat content was found in the PRID group as 2.47 ± 0.354%, and the highest value was in the PGF2-alpha group as 3.58 ± 0.207%. The difference in milk fat ratio between the groups was found to be significant (P < .05). However, the differences between the groups for other parameters were not significant (P > .05).Discussion: Among the reasons for the low values of the milk fat rates obtained in the present study than the mean values of all lactation milk fat rates of the Simmental breed, the effect of the lactation period in which the milk samples were collected comes to mind. Because, as we know, the first 45-60 day period following the start of lactation after parturition in cattle is accepted as the period in which daily milk yield reaches to the maximum level of the lactation period. This period lasts for a certain period of time, and then starts to decrease gradually. Among the non-hereditary factors, the most important factor causing changes in the composition of the milk and its amount is the lactation period. In this study, the significant difference in the milk fat rates between the control and the application groups is quite remarkable compared to the low level of milk fat rates in the milk in all groups. According to the multiple comparison test results to determine which groups these differences arise from, the difference was found to be particularly between the PGF2-alpha group and PRID group. In this study, no significant effects of different synchronization methods on all components of the milk except the milk fat and the density values were determined. But results indicate that Ovsynch group was the synchronization group that caused the minimum change in milk fat compared to the other groups.

scholarly journals Use of a five-day progesterone-based timed artificial insemination protocol for dairy water buffaloes

2017 ◽  
Vol 38 (6) ◽  
pp. 3927
Author(s):  
Luiz Francisco Machado Pfeifer ◽  
Natália Avila de Castro
Keyword(s):  
Artificial Insemination ◽  
Estradiol Benzoate ◽  
Gonadotropin Releasing Hormone ◽  
Control Group ◽  
Releasing Hormone ◽  
Water Buffaloes ◽  
Estrous Synchronization ◽  
Timed Artificial Insemination

The objective of this study was to determine the effect of a short five-day (5 d) progesterone-based timed artificial insemination (TAI) protocol on the time of ovulation and fertility in dairy water buffaloes. In experiment 1, 30 dairy buffaloes were subjected to one of two estrous synchronization protocols. Females in the control group (n=17) were administered 2 mg of estradiol benzoate (EB), and an intravaginal progesterone-releasing device (CIDR) was inserted on day -12. On day -3, CIDR inserts were removed and all cows were treated with 150 ?g of D-cloprostenol (a PGF2?-analogue). Forty-eight hours after CIDR removal, all cows received 100 µg of gonadotropin-releasing hormone (GnRH). Females assigned to the short 5 d group (n=13) received treatment similar to the control group, except that the CIDR device was inserted on day -8, and the EB treatment was eliminated. In experiment 2, 51 dairy buffaloes were separated into control (n=27) and short 5 d (n=24) groups that received the same treatment as described for cows in experiment 1, except that all females were inseminated 16 to 18 h after GnRH injection. The use of a short 5 d progesterone-based TAI protocol with or without treatment with EB on day 0 did not affect the time of ovulation and pregnancy per artificial insemination in lactating water buffaloes. Thus, we suggest that the short 5 d TAI protocol may be successfully used as an alternative to induce ovulation in dairy buffaloes, with the particular advantages of avoiding EB treatment and a shorter interval from the beginning of the protocol to TAI.

scholarly journals Is gonadotropin-releasing hormone agonist usage really leading to thyroid dysfunction?

2020 ◽  
Vol 11 (3) ◽  
pp. 136-138
Author(s):  
Nafiye Yilmaz ◽  
Necati Hancerliogullari ◽  
Mustafa Kara ◽  
Yaprak Engin-Ustun
Keyword(s):  
Cross Sectional Study ◽  
Gonadotropin Releasing Hormone ◽  
Cross Sectional ◽  
Serum Free ◽  
Releasing Hormone ◽  
Gonadotropin Releasing Hormone Agonist ◽  
Significant Difference ◽  
The Difference ◽  
Serum Tsh ◽  
Tsh Levels

Objectives Gonadotropin-releasing hormone agonist (GnRHa) could influence the levels of sex hormones and thyroid hormones. The aim of this study was to investigate the effect of GnRHa on thyroid function. Materials and methods The data of the patients were collected from the registrations of July 2014–October 2014. A total of 41 women who underwent one-time IVF cyclus were evaluated in this cross-sectional study. The patients were categorized into two groups according to the serum T3, T4, and TSH levels before and 2 weeks’ after the administration of GnRHa. Results Mean basal TSH and mean TSH levels on hCG day were 1.98 ± 0.77 and 1.75 ± 0.70, respectively. The difference between the two groups was statistically significant (p < 0.05). GnRHa did not lead to statistically significant difference on serum-free T3 and T4 levels. Conclusions In conclusion, our results demonstrate that GnRHa led to a decrease on serum TSH level. Serum-free T3 and T4 levels were remained unchanged and this might be due to early measurement of the hormone levels (just 2 weeks later from GnRHa administration).

scholarly journals The Early Start of Gonadotropin-releasing Hormone Antagonist Versus Flexible Antagonist Ovarian Stimulation Protocol in Poor Responders: A Randomized Clinical Trial

2020 ◽  
Author(s):  
Tayebeh Esfidani ◽  
Ashraf Moini ◽  
Arezoo Arabipoor ◽  
Maryam Farid Mojtahedi ◽  
Shima Mohiti ◽  
...  
Keyword(s):  
Ovarian Stimulation ◽  
Early Onset ◽  
Randomized Clinical Trials ◽  
Gonadotropin Releasing Hormone ◽  
Control Group ◽  
Early Start ◽  
Releasing Hormone ◽  
Significant Difference ◽  
And Control ◽  
Antagonist Group

Abstract Background: Determining the initiation day of antagonist administration is an important and challenging issue and different results have been reported in the previous studies. The present study was designed to compare the controlled ovarian hyperstimulation (COH) cycles outcomes of the early start of gonadotropin-releasing hormone antagonist (GnRH-ant) protocol with conventional flexible GnRH-ant protocol in patients with poor ovarian response (POR) diagnosis. Methods: This randomized controlled trial was performed on infertile women who were diagnosed as poor ovarian responder in IVF/ICSI cycles at Arash Women’s Hospital affiliated to Tehran University of Medical Sciences between September 2019 and May 2020. POR was defined according to the Bologna criteria and the eligible women were randomly allocated into an experimental (early onset GnRH-ant) and control (flexible GnRH-ant) groups. The women in the experimental group received recombinant gonadotropins (150-225 IU) and GnRH-ant (0.25 mg) simultaneously on the second day of the cycle. In control group, the starting and dose of gonadotropins were similar but daily administration of GnRH-ant was initiated when the leading follicle diameter was ≥ 13 mm. The IVF/ICSI outcomes were compared between groups.Results: Totally, 116 women were randomly assigned to early start antagonist group (n=58) and control group (n=58). The analysis showed that the two groups did not have a statistically significant difference in terms of the ovarian stimulation duration and the total dose of used gonadotropins. Although, the total number of MII oocytes in early start of antagonist group was significantly higher than that of in control group (P=0.04). In the following, clinical and ongoing pregnancy rates per ET in early start of antagonist group were significantly higher than those of in control group (P=0.02 and P=0.03, respectively); however, the implantation and miscarriage rates were similar between group.Conclusion: The early onset of GnRH-ant protocol can improve the number of retrieved and MII oocytes rates and probably the pregnancy outcome after fresh embryo transfer in POR patients; however, larger randomized clinical trials are required to compare the pregnancy outcomes after this approach with other COH protocols with considering cost-effectiveness issue.Trial registration: IRCT, IRCT20110731007165N9. Registered 8 February 2020 – Registered while recruiting, https://www.irct.ir/trial/45024.

Evaluation of the resilience of the girls with central precocious puberty treated with gonadotropin-releasing hormone analog

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Sevinc Odabasi Gunes ◽  
Onur Akin ◽  
Safak Eray
Keyword(s):  
Precocious Puberty ◽  
Negative Correlation ◽  
Central Precocious Puberty ◽  
Gonadotropin Releasing Hormone ◽  
Control Group ◽  
Adequate Treatment ◽  
Releasing Hormone ◽  
Long Term Treatment ◽  
Significant Difference ◽  
Weak Negative Correlation

Abstract Objectives The aim of this study was to evaluate the resilience of girls with central precocious puberty (CPP) during treatment with a gonadotropin-releasing hormone agonist (GnRHa) and compare these results with their healthy peers. Methods The Connor–Davidson Resilience Scale (CD-RISC) is a self-report scale used to quantify resilience, which is divided into seven subgroups (hardiness, coping, flexibility, purpose, optimism, regulation of emotion and cognition (REC), and self-efficacy). Fifty-one girls with CPP receiving GnRHa treatment and 51 healthy controls were involved in the study. Anthropometric measurements were evaluated and CD-RISC was performed at least six months after the initiation of GnRHa treatment. Results There was no statistically significant difference between the anthropometric evaluations of girls with CPP and the control group. Similarly, the total score and subgroup scores of patients with CPP and the control group showed no statistically significant difference. In the correlation analysis, there was a weak negative correlation between height and flexibility (r=−0.314 p=0.025), height SDS and flexibility (r=−0.254 p=0.092), height SDS, and purpose (r=−0.285 p=0.058). Also, there was a weak negative correlation between REC and weight (r=−0.435 p=0.003), REC and weight SDS (r=−0.461 p=0.002), REC and height (r=−0.269 p=0.077), REC and height SDS (r=−0.322 p=0.033), REC and BMI (r=−0.289 p=0.058), and REC and BMI SDS (r=−0.353 p=0.019). Conclusions The resilience of girls with CPP treated with GnRHa was found to be similar to their healthy peers. The early diagnosis of the disease and adequate treatment may decrease the discrepancy of somatic changes between girls with CPP and their peers, which may help them to overcome the stress of CPP and long-term treatment.

scholarly journals The Effect of Single and Triple Testicular Biopsy Using Biopty Gun on Spermatogenesis in Pubertal Rats

Animals ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1569
Author(s):  
Tomislav Šušnjar ◽  
Ivana Kuzmić Prusac ◽  
Ivan Švagelj ◽  
Anđela Jurišić ◽  
Tomislav Šušnjar ◽  
...  
Keyword(s):  
Sperm Count ◽  
Semen Analysis ◽  
Study Groups ◽  
Testicular Biopsy ◽  
Male Rats ◽  
Lower Percentage ◽  
Control Group ◽  
Sprague Dawley ◽  
Left Testis ◽  
Significant Difference

Background: The aim of this study was to compare consequences in single and triple testicular biopsy by biopty gun in pubertal rats using histological and immunohistochemical analysis. Methods: Thirty-two Sprague-Dawley male rats were used as the experimental model. The rats were randomly divided into three study groups. The rats from the first group (n = 12) received a single-biopsy of upper pole of the left testis, while the rats from the second group (n = 10) received triple-biopsy of upper and lower poles and lateral surface of left testis. The third group (n = 10) was a control group. On the eightieth day after the biopsy in all rats bilateral orchiectomy and funiculectomy were performed to obtain testicular tissue and sperm for analysis. The consequences of the puncture were observed by pathohistology, immunohistochemistry and semen analysis. Results: The results of the study showed lower percentage of sperm count (14.5 mill/mL vs. 16 mill/mL, p = 0.130), sperm motility (24.6% vs. 32.7%, p > 0.05), abnormal sperm (30% vs. 27%, p > 0.05), atrophic tubules (21% vs. 6%, p < 0.001), volume (1.7 mL vs. 2.28 mL, p < 0.01) and apoptotic index (1.56 vs. 1.19, p = 0.650) in the testes with a triple-biopsy compared to the testes with a single-biopsy. Semen analysis showed a borderline significant difference between the group with triple-biopsy where sperm count was lower than it in the control group (14.5 mill/mL vs. 17.5 mill/mL, p = 0.05). A single-biopsy has little effect on the testis, especially on overall fertility. A triple-biopsy showed higher degree of the testicular damage but without a significant impact on overall fertility. Semen analysis showed that single- and triple-biopsies did not have a significant effect on sperm count, motility and morphology. Conclusion: Biopty gun procedure is a cheap, simple and reliable method for testicular biopsy in rats without a significant effect on sperm count, motility and morphology.

scholarly journals QOLP-17. GROUP MEDICAL PLAY EFFECTIVELY IMPROVES HOSPITALIZATIONADAPTABILITY OF PEDIATRIC PATIENTS WITH NEUROTUMOR

2020 ◽  
Vol 22 (Supplement_2) ◽  
pp. ii178-ii178
Author(s):  
Xing Zhang ◽  
Fuqiang Zhang ◽  
Mingyao Lai ◽  
Juan Li ◽  
Yangqiong Zhang ◽  
...  
Keyword(s):  
Social Status ◽  
Pediatric Patients ◽  
Picture Book ◽  
Family Satisfaction ◽  
Control Group ◽  
Play Intervention ◽  
Significant Difference ◽  
The Difference ◽  
Therapeutic Play ◽  
Experimental Group

Abstract OBJECTIVE To explore the effect of group medical games on the hospitalization adaptability of pediatric patients with neuro tumor. METHODS pediatric patients with neuro tumor (age:6 to 13 years) who were treated in hospital from June to December 2019 and were hospitalized for 1 month to 2 months. 29 pediatric patients(mean age:9y) were selected as the control group and treated as usual; 26 pediatric patients(meanage:8y) were selected as the experimental group for group therapeutic play intervention. Interventions last Monday, Wednesday and Friday of each week, with an average duration of one hour. Group medical play include: medical picture book education, medical preview game, emotional games, social table games. Two groups completed self-made questionnaires at the time of admission and two weeks after admission, including: diet, sleep, compliance, and social status, hospital adaptation and other related issues, two groups completed a satisfaction questionnaire after two weeks of admission, recorded analysis and compared the difference of questionnaire data and satisfaction of the two groups of pediatric patients. RESULTS There was no statistical difference in age and sex between the two groups, and there was no significant difference in baseline RESULTS: The re-test results showed that the experimental group was significantly better than the control group in terms of social status, hospital adaptation, compliance and family satisfaction(p＜0.05). CONCLUSION Group medical games can effectively improve the adaptability, compliance and family satisfaction of pediatric with neuro tumor.

scholarly journals Comparison of Bax and Caspase-3 Protein Expression in Liver Cells following UVB Irradiation for 7 days and Treatment of Pimpinella alpina Molk during 7 and 15 days

2020 ◽  
Vol 19 (2) ◽  
pp. 296-303
Author(s):  
Eni Widayati ◽  
Taufiqurrachman Nasihun ◽  
Azizah Hikma Savitri ◽  
Nurina Tyagita
Keyword(s):  
Protein Expression ◽  
Caspase 3 ◽  
Medical Science ◽  
Liver Cells ◽  
Male Rats ◽  
Control Group ◽  
Sprague Dawley ◽  
Control Group Design ◽  
Uvb Irradiation ◽  
The Difference

Objective: The effect of Pimpinela alpina Molk (PaM) on decrease in Bax and Caspase-3 protein expression in liver cells apoptosis have been proven. However, the difference result between 7 and 15 days treatment duration of PaM need to be confirmed. This study aimed to confirm that treatment of PaM during 15 days is more effective decreasing Bax and Caspase-3 protein expression in liver cells following UVB irradiation. Methods: In the post test only control group design, 35 Sprague Dawley male rats, 300 gram body weight were divided into two arms, consisting of three groups respectively. First arm comprise Neg-7, PaM7-100, and PaM7-150. Second arm comprise Neg-15, PaM15-100, and PaM15-150. Nor-G was added as normal control neither exposed to UVB nor PaM treatment. In negative group was only radiated to UVB and PaM groups were exposed to UVB and treatment with 100, and 150 mg PaM per oral for 7 and 15 days respectively. At day 8 (first arm) and 16 (second arm), liver organ was taken and Bax and Caspase-3 protein expression assessed by Immunohistochemical staining method. Result: Post Hoc LSD analysis indicated that Bax and Caspase-3 protein expression in PaM15-100 and PaM15-150 was significant lower compared to that of Nor-G, PaM7-100, and PaM7-150, p < 0.05. Conclusion: Ttreatment of PaM with doses 100 and 150 mg for 15 days was better in decreasing Bax and Caspase-3 protein expression of liver cells following UVB irradiation. Bangladesh Journal of Medical Science Vol.19(2) 2020 p.296-303

Mainstream and Remedial School Attention Deficit Hyperactivity Disorder Boys: More Alike than Different

2005 ◽  
Vol 35 (1) ◽  
pp. 73-88
Author(s):  
J. B. Savitz ◽  
P. Jansen
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Control Group ◽  
Adhd Group ◽  
Hyperactivity Disorder ◽  
Significant Difference ◽  
Executive Deficits ◽  
Mainstream School ◽  
The Difference ◽  
Neuropsychological Tasks

The literature on the neuropsychology of Attention Deficit Hyperactivity Disorder (ADHD) is plagued by inconsistent findings, which are usually attributed to a variety of extraneous variables. One of the most inadequately explored of these variables is the difference between ADHD children attending remedial and mainstream schools. This study aimed to investigate whether the performance of remedial and mainstream school ADHD boys differs on relevant neuropsychological tasks. The sample consisted of three groups of 8- to 12-year-old boys. Two of these groups consisted of children with ADHD: one from remedial schools and one from mainstream schools. The third group was made up of participants without ADHD, who attended mainstream schools. The performance of the remedial school learners on the Stroop, Lurian and cancellation tasks was investigated and compared to a mainstream school ADHD sample. The performance of the ADHD group as a whole was compared with that of a control group. No significant difference in performance was found between the two ADHD groups, except for the length of time taken to read words in the control condition of the Stroop. The control group out-performed the ADHD samples on the Stroop, Lurian and cancellation tasks. The findings suggest that mainstream and remedial ADHD boys do not differ in the severity of their executive deficits, but that boys with ADHD attending remedial schools may be more likely to have another learning disorder than their counterparts at mainstream schools.

Sign in / Sign up

Export Citation Format

Share Document