The molecular biology of SRY and its role in sex determination in mammals

1995 ◽  
Vol 7 (4) ◽  
pp. 713 ◽  
Author(s):  
P Koopman
Keyword(s):  
Molecular Biology ◽  
Transgenic Mice ◽  
Sex Determination ◽  
Gene Product ◽  
Mode Of Action ◽  
Recent Progress ◽  
Sry Gene ◽  
Testis Development ◽  
Direct Demonstration

SRY is the gene that initiates the genetic cascade leading to testis development in mammals. Since its discovery in 1990 and the direct demonstration of its male-determining role in transgenic mice, attention has turned to understanding the biochemical mode of action of the SRY gene product, and to the identification of other genes in the sex-determining pathway. Recent progress in these efforts is summarized in this review.

scholarly journals Recent Progress in Torovirus Molecular Biology

Viruses ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 435
Author(s):  
Makoto Ujike ◽  
Fumihiro Taguchi
Keyword(s):  
Molecular Biology ◽  
Recent Progress ◽  
Reverse Genetics ◽  
Cultured Cells ◽  
Host Adaptation ◽  
Economic Losses ◽  
New Family ◽  
Enteric Diseases ◽  
Long Time ◽  
Medical Importance

Torovirus (ToV) has recently been classified into the new family Tobaniviridae, although it belonged to the Coronavirus (CoV) family historically. ToVs are associated with enteric diseases in animals and humans. In contrast to CoVs, which are recognised as pathogens of veterinary and medical importance, little attention has been paid to ToVs because their infections are usually asymptomatic or not severe; for a long time, only one equine ToV could be propagated in cultured cells. However, bovine ToVs, which predominantly cause diarrhoea in calves, have been detected worldwide, leading to economic losses. Porcine ToVs have also spread globally; although they have not caused serious economic losses, coinfections with other pathogens can exacerbate their symptoms. In addition, frequent inter- or intra-recombination among ToVs can increase pathogenesis or unpredicted host adaptation. These findings have highlighted the importance of ToVs as pathogens and the need for basic ToV research. Here, we review recent progress in the study of ToV molecular biology including reverse genetics, focusing on the similarities and differences between ToVs and CoVs.

A PCR assay for sex determination of yak (Bos grunniens) meat by amplification of the male-specific SRY gene

Food Control ◽  
2010 ◽  
Vol 21 (5) ◽  
pp. 726-731 ◽  
Author(s):  
W.L. Bai ◽  
R.H. Yin ◽  
S.J. Zhao ◽  
C. Li ◽  
Z.J. Ma ◽  
...  
Keyword(s):  
Sex Determination ◽  
Sry Gene ◽  
Pcr Assay ◽  
Bos Grunniens ◽  
Male Specific

Chemistry, Molecular Biology and Mode of Action of Parathyroid Hormone

1989 ◽  
pp. 11-18
Author(s):  
J. T. Potts ◽  
S. Nussbaum ◽  
K. Wiren ◽  
M. Freeman ◽  
T. Igarashi ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Molecular Biology ◽  
Mode Of Action

scholarly journals Gadd45g Is Essential for Primary Sex Determination, Male Fertility and Testis Development

PLoS ONE ◽  
2013 ◽  
Vol 8 (3) ◽  
pp. e58751 ◽  
Author(s):  
Heiko Johnen ◽  
Laura González-Silva ◽  
Laura Carramolino ◽  
Juana Maria Flores ◽  
Miguel Torres ◽  
...  
Keyword(s):  
Sex Determination ◽  
Male Fertility ◽  
Testis Development

Amplification and application of the HMG box of bovine SRY gene for sex determination

2007 ◽  
Vol 100 (1-2) ◽  
pp. 186-191 ◽  
Author(s):  
Wenfa Lu ◽  
Norman Rawlings ◽  
Jing Zhao ◽  
Heng Wang
Keyword(s):  
Sex Determination ◽  
Sry Gene ◽  
Hmg Box

A Survey of Recent Progress in Phosphorus-Based Flame Retardants and Some Mode of Action Studies

1999 ◽  
Vol 144 (1) ◽  
pp. 17-20 ◽  
Author(s):  
Edward D. Weil ◽  
Sergei V. Levchik ◽  
Maney Ravey ◽  
Weiming Zhu
Keyword(s):  
Mode Of Action ◽  
Flame Retardants ◽  
Recent Progress

scholarly journals The bcl-2 gene product inhibits clonal deletion of self-reactive B lymphocytes in the periphery but not in the bone marrow.

1993 ◽  
Vol 178 (4) ◽  
pp. 1247-1254 ◽  
Author(s):  
S Nisitani ◽  
T Tsubata ◽  
M Murakami ◽  
M Okamoto ◽  
T Honjo
Keyword(s):  
Bone Marrow ◽  
B Cells ◽  
Transgenic Mice ◽  
Gene Product ◽  
B Lymphocytes ◽  
Immunoglobulin Genes ◽  
Clonal Deletion ◽  
Immature B Cells ◽  
B1 Cells ◽  
Self Antigen

To test whether the product of the bcl-2 proto-oncogene blocks clonal deletion of self-reactive B cells, we have generated transgenic mice carrying the bcl-2 gene and the immunoglobulin genes for the anti-erythrocyte 4C8 antibody. In these transgenic mice, clonal deletion of self-reactive immature B cells in the bone marrow was not inhibited in spite of expression of the bcl-2 gene. In contrast, self-antigen-induced clonal deletion of mature self-reactive Ly-1 B (B1) cells in the peritoneal cavity was inhibited in the transgenic mice. These results indicate that the mechanism for clonal deletion of immature self-reactive B cells in the bone marrow differs from that of mature self-reactive B cells in the periphery.

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