Studies on glucocorticoid hormone actions in the regulation of human amnion PGHS

1995 ◽  
Vol 7 (3) ◽  
pp. 517 ◽  
Author(s):  
T Zakar ◽  
DM Olson
Keyword(s):  
Protein Phosphorylation ◽  
Transcriptional Activity ◽  
Inhibitory Protein ◽  
Induced Expression ◽  
Human Amnion ◽  
Prostaglandin Endoperoxide ◽  
Excellent Model ◽  
Glucocorticoid Hormone ◽  
Endoperoxide H Synthase

The human amnion is an excellent model in which to study the regulation of the expression of prostaglandin endoperoxide H synthase-2 (PGHS-2) mRNA by glucocorticoids, as glucocorticoids can both stimulate and inhibit PGHS activity and can have their stimulatory effect reversed to an inhibitory one. Our studies suggest the presence of a glucocorticoid-induced inhibitory protein which affects the post-transcriptional activity of PGHS-2 mRNA. Glucocorticoid-induced expression of PGHS-2 mRNA may be dependent on protein phosphorylation.

scholarly journals Regulation of prostaglandin endoperoxide H synthase by glucocorticoids and activators of protein kinase C in the human amnion

Reproduction ◽  
1994 ◽  
Vol 100 (1) ◽  
pp. 43-50 ◽  
Author(s):  
T. Zakar ◽  
F. J. Teixeira ◽  
J. J. Hirst ◽  
F. Guo ◽  
E. A. MacLeod ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Human Amnion ◽  
Prostaglandin Endoperoxide ◽  
Kinase C ◽  
Endoperoxide H Synthase
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