Experimental strategies for the development of an immunocontraceptive vaccine for the European red fox, Vulpes vulpes

1994 ◽  
Vol 6 (3) ◽  
pp. 307 ◽  
Author(s):  
MP Bradley
Keyword(s):  
Reproductive Tract ◽  
Mucosal Immune Response ◽  
Antigen Delivery ◽  
Effective Form ◽  
Sperm Antigens ◽  
Long Term Impact ◽  
Experimental Strategies ◽  
Selection Of ◽  
Immunocontraceptive Vaccine

The development of an immunocontraceptive vaccine to control fox populations in Australia would confer considerable advantages in controlling the long-term impact of this predator on native and endangered species. Studies are currently under way to identify sperm antigens that might be used in such a vaccine, and some of these studies are described. It is proposed that such a vaccine would be delivered orally in a bait, thereby stimulating a mucosal immune response to the foreign antigen(s). Such a vaccine requires a detailed understanding of reproductive-tract mucosal immunity in foxes, and selection of the most effective form of antigen delivery. Those under consideration include viral or bacterial vectors and microencapsulated antigens.

A bait-delivered immunocontraceptive vaccine for the European red fox (Vulpes vulpes) by the year 2002?

1997 ◽  
Vol 9 (1) ◽  
pp. 111 ◽  
Author(s):  
Mark P. Bradley ◽  
Lyn A. Hinds ◽  
Peter H. Bird
Keyword(s):  
Immune Responses ◽  
Oral Delivery ◽  
Reproductive Tract ◽  
Recombinant Expression ◽  
Vaccine Delivery ◽  
Mucosal Immune Response ◽  
Female Reproductive Tract ◽  
Mucosal Antibody ◽  
Sperm Antigens ◽  
Immunocontraceptive Vaccine

An orally-delivered immunocontraceptive vaccine is being developed for the control of fox populations. A number of genes (PH-20, LDH-C4, ZP3) encoding gamete proteins have been cloned, produced in recombinant expression systems and used in fertility trials to test the efficacy of these antigens. As the immunocontraceptive vaccine will be delivered in a bait, there is a requirement for a greater understanding of the immune responses of the reproductive mucosa in canids, and the assessment of the best vaccine delivery system that will evoke a mucosal antibody response. Several vaccine delivery systems including microencapsulated antigens, and both vaccinia virus and bacterial vectors are being investigated. Oral administration of Salmonella typhimurium recombinants expressing different fox sperm antigens stimulates both systemic IgG responses to the antigen and a mucosal immune response within the female reproductive tract in the fox, indicating that salmonella may have potential with respect to the oral delivery of antigen. The enhancement of mucosal immune responses to orally-delivered vaccines is also being examined, research focussing on the possible use of fox-specific cytokines or the β-subunit of cholera toxin in forming part of the vaccine construct.

Impact of Covid 19 Induced Conditions on the Consumer Behavior on A Short, Mid and Long Term, for Consumption of Services

2021 ◽  
Vol 12 (2) ◽  
pp. 1906-1923
Author(s):  
Shripad Joshi, Et. al.
Keyword(s):  
Consumer Behavior ◽  
Health And Safety ◽  
Primary Objective ◽  
Primary Data ◽  
The People ◽  
The Government ◽  
Long Term Impact ◽  
The Impact ◽  
Selection Of

The covid-19 pandemic has demonstrated the interconnected and quiet picture of the nation with humans without their human touch – and that no one is safe until everyone is safe. With this pandemic different changes taken place and after fighting and juggling with it for around 4 months, consumers accepted the fact “this is new normal”. But this pandemic affected as well as changed the pattern of consumer behavior in so many ways be it behavioral change or psychological change. As the current situation made us all come across a lot of newness and to study that change in consumer behavior, my internship was an attempt to do a research on the impact of Covid19 induced conditions on the consumer behavior on a short, mid and long term impact for consumption of services. This research was taken out to understand the same in better way. In the tenure of two months of my internship was to carry out a detailed analysis of consumer behavior in terms of services and their impact. This project’s primary objective was to perform set of task in order to study different psychological changes taking place in consumer for achieving the same I have giving following task which needs to be followed in the mentioned sequence itself. The tasks were mainly divided into five sets: Background study and collection of information related to covid-19. Preparation of questionnaire on the basis of Primary data collection from respondent (min.300) on telephonic Analysis of data and key findings Formation of report on the collected information This market research was carried out with constraint, provided from the external mentor in terms of the selection of respondent. Covid-19 made a great impact on the consumer behavior in just a course of few months as few restrictions were imposed on the Indian citizen by the government of India to make sure health and safety of the people. This study in only recited to consumer of India who reside in India itself for a focused study and targeted group of people. Alongside this there was great learning regarding some technical knowledge like working on excel and analysis of the respondent’s response.

Crisis Phones - Suicide Prevention Versus Suggestion/Contagion Effects

Crisis ◽  
2015 ◽  
Vol 36 (3) ◽  
pp. 220-224 ◽  
Author(s):  
Steven Stack
Keyword(s):  
Suicide Prevention ◽  
Contagion Effects ◽  
Long Term Impact

Abstract. Background: There has been no systematic work on the short- or long-term impact of the installation of crisis phones on suicides from bridges. The present study addresses this issue. Method: Data refer to 219 suicides from 1954 through 2013 on the Skyway Bridge in St. Petersburg, Florida. Six crisis phones with signs were installed in July 1999. Results: In the first decade after installation, the phones were used by 27 suicidal persons and credited with preventing 26 or 2.6 suicides a year. However, the net suicide count increased from 48 in the 13 years before installation of phones to 106 the following 13 years or by 4.5 additional suicides/year (t =3.512, p < .001). Conclusion: Although the phones prevented some suicides, there was a net increase after installation. The findings are interpreted with reference to suggestion/contagion effects including the emergence of a controversial bridge suicide blog.

Long-Term Impact of Participation in the Adolescent Diversion Project

2009 ◽  
Author(s):  
Jenna L. Claes ◽  
Sean S. Hankins ◽  
J. K. Ford
Keyword(s):  
Long Term Impact

966-P: The Long-Term Impact of a Flash Glucose Monitoring System on Glycemic Control

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 966-P
Author(s):  
ATSUSHI FUJIYA ◽  
TOSHIKI KIYOSE ◽  
TAIGA SHIBATA ◽  
HIROSHI SOBAJIMA
Keyword(s):  
Glycemic Control ◽  
Monitoring System ◽  
Glucose Monitoring ◽  
Flash Glucose Monitoring ◽  
Long Term Impact ◽  
Flash Glucose Monitoring System

Dual lumen intervention for aortic dissection: long-term impact on aortic remodeling

2020 ◽  
Vol 27 (1) ◽  
Author(s):  
Xun Yuan ◽  
Andreas Mitsis ◽  
Thomas Semple ◽  
Michael Rubens ◽  
Christoph A. Nienaber
Keyword(s):  
Aortic Dissection ◽  
Long Term Impact ◽  
Aortic Remodeling
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