Structure-function relationships and mechanism of action of pituitary and placental gonadotrophins

1994 ◽  
Vol 6 (2) ◽  
pp. 157 ◽  
Author(s):  
F Apparailly ◽  
V Laurent-Cadoret ◽  
F Lecompte ◽  
M Chopineau ◽  
MC Maurel ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Receptor Binding ◽  
Mechanism Of Action ◽  
Follicle Stimulating Hormone ◽  
Mechanisms Of Action ◽  
Structure And Function ◽  
Target Cells ◽  
Beta Subunits ◽  
And Function ◽  
Homologous Desensitization

Data from the author's laboratory on relationships between structure and function of equine luteinizing hormone, follicle-stimulating hormone and choriogonadotrophin as well as their mechanisms of action are reviewed and compared with their human counterparts. Polymorphism of these hormones and problems associated with their purification are discussed as well as the association and dissociation of their alpha- and beta-subunits. The affinity of receptor binding, the superactivity of membrane transduction and homologous desensitization of target cells by non-stimulatory doses of the gonadotrophins are also reviewed.

scholarly journals Regulation of synaptic structure and function by palmitoylated AMPA receptor binding protein

2010 ◽  
Vol 43 (4) ◽  
pp. 341-352 ◽  
Author(s):  
Charu Misra ◽  
Sophie Restituito ◽  
Jainne Ferreira ◽  
Gerald A. Rameau ◽  
Jie Fu ◽  
...  
Keyword(s):  
Ampa Receptor ◽  
Receptor Binding ◽  
Binding Protein ◽  
Structure And Function ◽  
Synaptic Structure ◽  
Ampa Receptor Binding Protein ◽  
And Function ◽  
Receptor Binding Protein

Structure and Function Relationship of Murine Insulin-like Peptide 5 (INSL5): Free C-Terminus Is Essential for RXFP4 Receptor Binding and Activation

Biochemistry ◽  
2011 ◽  
Vol 50 (39) ◽  
pp. 8352-8361 ◽  
Author(s):  
Alessia Belgi ◽  
Mohammed A. Hossain ◽  
Fazel Shabanpoor ◽  
Linda Chan ◽  
Suode Zhang ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Structure And Function ◽  
C Terminus ◽  
Function Relationship ◽  
Structure And Function Relationship ◽  
And Function ◽  
Relationship Of

Steroid structure and function—IX. Molecular conformation and receptor binding of isomeric analogs of d-Homo-Estradiol

1981 ◽  
Vol 14 (1) ◽  
pp. 1-7 ◽  
Author(s):  
William L. Duax ◽  
G.David Smith ◽  
Dale C. Swenson ◽  
Phyllis D. Strong ◽  
Charles M. Weeks ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Molecular Conformation ◽  
Structure And Function ◽  
And Function ◽  
Steroid Structure

scholarly journals Cytochemical Studies of the Effects of Activin on Gonadotropin-releasing Hormone (GnRH) Binding by Pituitary Gonadotropes and Growth Hormone Cells

1997 ◽  
Vol 45 (12) ◽  
pp. 1603-1610 ◽  
Author(s):  
Gwen V. Childs ◽  
Geda Unabia
Keyword(s):  
Growth Hormone ◽  
Luteinizing Hormone ◽  
Follicle Stimulating Hormone ◽  
Gonadotropin Releasing Hormone ◽  
Target Cells ◽  
Pituitary Cells ◽  
Releasing Hormone ◽  
Average Area ◽  
Gnrh Receptors ◽  
Gh Cells

Activin stimulates the synthesis and secretion of follicle-stimulating hormone (FSH). It inhibits the synthesis and release of growth hormone (GH). It acts on gonadotropes by stimulating the synthesis of gonadotropin-releasing hormone (GnRH) receptors. To test activin's effects on GnRH target cells, pituitary cells from diestrous or proestrous rats were exposed to media with and without 60 ng/ml activin for 24 hr and stimulated with biotinylated GnRH (Bio-GnRH). The populations were double-labeled for Bio-GnRH and/or luteinizing hormone-β (LH-β), FSH-β, or GH antigens. In both diestrous and proestrous rats, activin stimulated more LH and FSH cells and increased the percentages of GnRH target cells. In diestrous rats, activin stimulated increases in the average area and density of Bio-GnRH label on target cells. In addition, more FSH, LH, and GH cells bound Bio-GnRH. The increment in binding by gonadotropes was not as great as that normally seen from diestrus to proestrus, suggesting that additional factors (such as estradiol) may be needed. These data suggest that activin plays an important role in the augmentation of Bio-GnRH target cells normally seen before ovulation. Its actions on GH cells may reflect a role in the transitory change from a somatotrope to a somatogonadotrope that is seen from diestrus to proestrus.

scholarly journals Monoclonal antibodies reacting with multiple epitopes on the human insulin receptor

1986 ◽  
Vol 235 (1) ◽  
pp. 199-208 ◽  
Author(s):  
M A Soos ◽  
K Siddle ◽  
M D Baron ◽  
J M Heward ◽  
J P Luzio ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Insulin Receptor ◽  
Human Insulin ◽  
Human Placenta ◽  
Structure And Function ◽  
Beta Subunits ◽  
Intact Cells ◽  
Receptor Structure ◽  
Human Insulin Receptor ◽  
And Function

Monoclonal antibodies for the human insulin receptor were produced following immunization of mice with IM-9 lymphocytes and/or purified placental receptor. Four separate fusions yielded 28 antibodies, all of which reacted with receptor from human placenta, liver and IM-9 cells. Some antibodies cross-reacted to varying degrees with receptor from rabbit, cow, pig and sheep, but none reacted with rat receptor. At least 10 distinct epitopes were recognized as indicated by species specificity and binding competition experiments. All of these epitopes appeared to be on extracellular domains of the receptor as shown by binding of antibodies to intact cells. In some cases the epitopes were further localized to alpha or beta subunits by immunoblotting. Several antibodies inhibited binding of 125I-insulin to the receptor, some had no effect on binding, and others enhanced the binding of 125I-insulin. It is concluded that these antibodies will be valuable probes of receptor structure and function.

Structure and Function of the Branched Receptor-Binding Complex of Bacteriophage CBA120

2019 ◽  
Vol 431 (19) ◽  
pp. 3718-3739 ◽  
Author(s):  
Michel Plattner ◽  
Mikhail M. Shneider ◽  
Nikolay P. Arbatsky ◽  
Alexander S. Shashkov ◽  
Alexander O. Chizhov ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Structure And Function ◽  
And Function
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