Di-n-butyl phthalate diminishes testicular steroidogenesis by blocking the hypothalamic–pituitary–testicular axis: relationship with germ cell apoptosis in Japanese quail

2021 ◽  
Author(s):  
Mohammad Shah Alam ◽  
Masamichi Kurohmaru
Keyword(s):  
Germ Cell ◽  
Japanese Quail ◽  
Cell Apoptosis ◽  
Germ Cell Apoptosis ◽  
Testicular Steroidogenesis ◽  
Butyl Phthalate

Bcl-2 and Bax are involved in experimental cryptorchidism-induced testicular germ cell apoptosis in rhesus monkey

Contraception ◽  
2003 ◽  
Vol 68 (4) ◽  
pp. 297-301 ◽  
Author(s):  
Zhi-Hong Zhang ◽  
Xuan Jin ◽  
Xue-Sen Zhang ◽  
Zhao-Yuan Hu ◽  
Ru-Jin Zou ◽  
...  
Keyword(s):  
Rhesus Monkey ◽  
Germ Cell ◽  
Cell Apoptosis ◽  
Testicular Germ Cell ◽  
Germ Cell Apoptosis

scholarly journals TheCaenorhabditis elegans ing-3Gene Regulates Ionizing Radiation-Induced Germ-Cell Apoptosis in a p53-Associated Pathway

Genetics ◽  
2008 ◽  
Vol 181 (2) ◽  
pp. 473-482 ◽  
Author(s):  
Jingjing Luo ◽  
Sitar Shah ◽  
Karl Riabowol ◽  
Paul E. Mains
Keyword(s):  
Ionizing Radiation ◽  
Germ Cell ◽  
Cell Apoptosis ◽  
Germ Cell Apoptosis ◽  
Radiation Induced

Minocycline up-regulates BCL-2 levels in mitochondria and attenuates male germ cell apoptosis

2005 ◽  
Vol 337 (2) ◽  
pp. 663-669 ◽  
Author(s):  
Mark Castanares ◽  
Yanira Vera ◽  
Krista Erkkilä ◽  
Sauli Kyttänen ◽  
Yanhe Lue ◽  
...  
Keyword(s):  
Germ Cell ◽  
Cell Apoptosis ◽  
Male Germ Cell ◽  
Germ Cell Apoptosis

scholarly journals Transient Testicular Warming Enhances the Suppressive Effect of Testosterone on Spermatogenesis in Adult Cynomolgus Monkeys (Macaca fascicularis)

2006 ◽  
Vol 91 (2) ◽  
pp. 539-545 ◽  
Author(s):  
Yanhe Lue ◽  
Christina Wang ◽  
Yi-Xun Liu ◽  
Amiya P. Sinha Hikim ◽  
Xue-Sen Zhang ◽  
...  
Keyword(s):  
Germ Cell ◽  
Cell Apoptosis ◽  
Synergistic Effects ◽  
Recovery Period ◽  
Heat Exposure ◽  
Suppressive Effect ◽  
Controlled Study ◽  
Cynomolgus Monkeys ◽  
Germ Cell Apoptosis ◽  
Sperm Counts

Context: The context of the study was to examine whether combined testosterone (T) and heat (H) treatment have additive or synergistic effects on suppression of spermatogenesis. Objective: The objective of the study was to determine whether T+H induces a greater suppression of spermatogenesis than either treatment alone in monkeys. Design: The study was a randomized, placebo-controlled study. Setting: The study was conducted at a primate center in China. Participants: The study population was comprised of 32 adult cynomolgus monkeys. Interventions: Groups of eight adult monkeys were treated for 12 wk with: 1) two empty implants (C); 2) two T implants (T); 3) daily testicular heat exposure (43 C for 30 min) for 2 consecutive days (H); or 4) two T implants plus testicular heat exposure (T+H). Treatment was followed by an 8-wk recovery period. Main Outcome Measures: Measures included sperm counts and germ cell apoptosis. Results: Serum T levels were elevated in both the T and T+H groups during treatment but not in the C or H group. Sperm counts were transiently suppressed after heat to 16.4% of baseline at 4 wk and then returned to pretreatment levels. Sperm counts were suppressed slowly after T treatment to nadir of 6.4% of pretreatment levels at 12 wk. T+H rapidly suppressed sperm output as early as 4 wk to 3.9% of pretreatment levels that was maintained throughout treatment. The decreased sperm counts were due to increased germ cell apoptosis in all treatment groups. Sperm counts recovered to the pretreatment levels in all groups by 8 wk after treatment. Conclusion: This proof-of-concept study demonstrates that transient testicular warming enhances and hastens the effect of T implant on the suppression of spermatogenesis in monkeys.

Targeted disruption of galectin 3 in mice delays the first wave of spermatogenesis and increases germ cell apoptosis

2021 ◽  
Author(s):  
Tao Lei ◽  
Sandra M. Blois ◽  
Nancy Freitag ◽  
Martin Bergmann ◽  
Sudhanshu Bhushan ◽  
...  
Keyword(s):  
Germ Cell ◽  
Cell Apoptosis ◽  
Targeted Disruption ◽  
Germ Cell Apoptosis ◽  
Galectin 3
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