Fertility and the transition dairy cow

2018 ◽  
Vol 30 (1) ◽  
pp. 85 ◽  
Author(s):  
J. R. Roche ◽  
C. R. Burke ◽  
M. A. Crookenden ◽  
A. Heiser ◽  
J. L. Loor ◽  
...  
Keyword(s):  
Metabolic Diseases ◽  
Transition Period ◽  
Fold Increase ◽  
Negative Energy ◽  
Smooth Transition ◽  
Ovarian Activity ◽  
Transition Cow ◽  
Research Findings ◽  
Metabolic Challenge

The transition from pregnancy to lactation (i.e. the transition period) is a time of significant metabolic challenge, with a several-fold increase in a cow’s requirement for energy, protein and minerals within days of calving. A successful transition involves the initiation and coordination of changes in multiple tissues that facilitate the provision of these nutrients to the cow and, more specifically, to the mammary gland, often at the considerable expense of other tissues. Failure to coordinate the necessary changes effectively results in transition period maladaptation, which can broadly be grouped into three categories: (1) negative energy balance and metabolic diseases associated with energy metabolism; (2) immune dysfunction and inflammation; and (3) metabolic diseases associated with mineral deficiency. Because reinitiation of ovarian activity, follicle recruitment, ovulation, fertilisation and, potentially, even maternal recognition of pregnancy and implantation occur against the backdrop of this metabolic and immunological disturbance in early lactation, the role of nutrition in ensuring a smooth transition between the pregnant and lactating state is important. In this paper we integrate recent research findings with previous knowledge of the interaction between transition cow metabolism and nutrition and reproductive outcomes, and offer new insights into key elements of successful cow management to avoid transition ‘maladaptation’ and improve pregnancy rates.

scholarly journals Managing the transition period of dairy cows to prevent major metabolic postpartum disorders

2017 ◽  
Vol 60 (4) ◽  
pp. 544
Author(s):  
C. N. BROZOS ◽  
E. KALAITZAKIS ◽  
N. PANOUSIS
Keyword(s):  
Dairy Cows ◽  
Dry Matter ◽  
Metabolic Diseases ◽  
Transition Period ◽  
Good Health ◽  
Dry Matter Intake ◽  
Reproductive Efficiency ◽  
Transition Cow ◽  
Postpartum Disorders ◽  
Abomasal Displacement

The transition period refers to the time between 3-4 weeks prior to and 4 weeks after calving. This is the period with the highest incidence of metabolic and other periparturient disorders. Many of these disorders interrelated and often coincide. Proper management and nutrition of the transition cow are critical for obtaining maximum dry matter intake, good health, increased reproductive efficiency and optimum milk production in the following lactation. The present review is comprised from two parts. In the first one, selected information is provided concerning the most important metabolic diseases of the transition period (hypocalcemia, ketosis) and, in brief, how hypocalcemia is interrelated to other diseases (mastitis, metritis, retained fetal membranes and abomasal displacement). In the second part, up-to-date nutritional methods applied in the transition period to prevent these metabolic periparturient diseases, with emphasis in hypocalcemia, are described.

scholarly journals Evaluation of some metabolic profile parameters in transition cows: thresholds for estimating postpartum diseases in Aydin province

2021 ◽  
Vol 24 (1) ◽  
pp. 108-118
Author(s):  
S. Erdoğan ◽  
K. Ural
Keyword(s):  
Metabolic Diseases ◽  
Transition Period ◽  
Body Condition Score ◽  
Threshold Value ◽  
Negative Energy ◽  
Operating Characteristics ◽  
Transition Cows ◽  
Condition Score ◽  
Biological Tests ◽  
Subclinical Hypocalcaemia

This study aimed to evaluate non-esterified fatty acids (NEFA), beta hydroxybutyric acid (BHBA), magnesium (Mg2+), calcium (Ca2+) and lactate as biological tests for the detection of some metabolic diseases during transition period in selected dairy farms located in Aydın province. Cow-side analysis with body condition score evalutation were performed weekly in at least 12 dairy cattle from each farm from prepartum week 2 to postpartum week 2. According to the prepartum NEFA ≥0.4 mmol/L, postpartum BHBA ≥1.4 mmol/L and Ca2+ ≤ 2.0 mmol/L at parturition (day 0) in herd-based evaluation, it was observed that all farms were positively evaluated for negative energy balance and also at risk for subclinical hypocalcaemia. Regarding the threshold value of Mg2+ <0.61 mmol/L, subclinical hypomagnesaemia was observed at the Ist and IInd farms. It was concluded that prepartum NEFA threshold (0.68 mmol/L), obtained from the receiver operating characteristics statistical analysis could be used for observing some postpartum clinical diseases. It was suggested that it allowed planning and strategic interventions to prevent herd-based diseases in Turkey and will be a precedent for future studies and herd management.

Plasminogen Activation In Vivo upon Intravenous Infusion of DDAVP

1992 ◽  
Vol 67 (01) ◽  
pp. 111-116 ◽  
Author(s):  
Marcel Levi ◽  
Jan Paul de Boer ◽  
Dorina Roem ◽  
Jan Wouter ten Cate ◽  
C Erik Hack
Keyword(s):  
Monoclonal Antibodies ◽  
Plasminogen Activator ◽  
Plasma Levels ◽  
Fold Increase ◽  
Fibrinolytic System ◽  
Plasminogen Activation ◽  
Plasminogen Activator Activity ◽  
Insight Into

SummaryInfusion of desamino-d-arginine vasopressin (DDAVP) results in an increase in plasma plasminogen activator activity. Whether this increase results in the generation of plasmin in vivo has never been established.A novel sensitive radioimmunoassay (RIA) for the measurement of the complex between plasmin and its main inhibitor α2 antiplasmin (PAP complex) was developed using monoclonal antibodies preferentially reacting with complexed and inactivated α2-antiplasmin and monoclonal antibodies against plasmin. The assay was validated in healthy volunteers and in patients with an activated fibrinolytic system.Infusion of DDAVP in a randomized placebo controlled crossover study resulted in all volunteers in a 6.6-fold increase in PAP complex, which was maximal between 15 and 30 min after the start of the infusion. Hereafter, plasma levels of PAP complex decreased with an apparent half-life of disappearance of about 120 min. Infusion of DDAVP did not induce generation of thrombin, as measured by plasma levels of prothrombin fragment F1+2 and thrombin-antithrombin III (TAT) complex.We conclude that the increase in plasminogen activator activity upon the infusion of DDAVP results in the in vivo generation of plasmin, in the absence of coagulation activation. Studying the DDAVP induced increase in PAP complex of patients with thromboembolic disease and a defective plasminogen activator response upon DDAVP may provide more insight into the role of the fibrinolytic system in the pathogenesis of thrombosis.

Design and Testing of an Experimental IPv4-to-IPv6 Transition Network

2006 ◽  
Vol 3 (1) ◽  
pp. 27
Author(s):  
Mustaffa Samad
Keyword(s):  
Transition Period ◽  
Internet Protocol ◽  
Smooth Transition ◽  
Internet Users ◽  
Ipv6 Transition ◽  
Information And Communication ◽  
Ipv6 Networks ◽  
And Migration ◽  
Set Up ◽  
Design And Testing

The Internet has been an integral part of the Information and Communication Technology (ICT) community in recent years. New internet users have been growing steadily over the years. This has lead to the depletion of new Internet Protocol (IP) addresses worldwide. To overcome this predicament, the new Internet Protocol version 6 (IPv6) had been introduced. The existing Internet Protocol version 4 (IPv4) is expected to be eventually replaced by this IPv6. The changeover from IPv4 to IPv6 is expected to be implemented progressively. During this transition period, these two protocols are expected to coexist for a number of years. IPv4-to-IPv6 transition tools have been designed to facilitate a smooth transition from IPv4 to IPv6. The two most basic IPv4-to-IPv6 transition tools available are the hybrid stack mechanism and tunneling. Tunneling is the encapsulation of IPv6 traffic within IPv4 packets so they can be sent over an IPv4 infrastructure. This project was initiated to set up an experimental IPv6 testbed, in order to study the performance as well as transition and migration issues of IPv6 networks under controlled conditions. This paper looks at how tunneling can be performed over existing internetwork infrastructure at Fakulti Kejuruteraan Elektrik (FKE), UiTM.

PERAN KELEMBAGAAN LOKAL DALAM PENGELOLAAN PERIKANAN DI ERA DESENTRALISASI

2018 ◽  
Vol 2 (1) ◽  
pp. 91
Author(s):  
Mustaqim - Mustaqim
Keyword(s):  
Phenomenological Approach ◽  
Validity And Reliability ◽  
Fishery Resources ◽  
Depth Interview ◽  
Research Findings ◽  
Interpretation Process ◽  
The Government ◽  
Critical Interpretation ◽  
Centralization And Decentralization

Abstract. The purpose of this research is to analyze the role of Panglima Laot in the management of fishery resources in Sabang Island. To be able to understand the fisheries management that involves the role of the community in the form of local institutions, a series in-depth interview, observation, as well as literature were successfully carried out to local fishery community. Since this study is a combination of qualitative and quantitative method, the data collection was analysed using phenomenological approach and critical interpretation process to see the validity and reliability of the research findings.  Referring to previous research evidence, the results show that the presence of Panglima Laot has played an important role in providing information, invitation, supervision and participation in the management of fishery resources. In addition, the role of Panglima Laot in the management of fishery resources includes carrying out customs, assisting the government, resolving conflicts in the community, preventing illegal fishing, preserving the coastal environment and fighting for the living standards of fishermen is very influential both in centralization and decentralization era.  Therefore, these findings can be categorized as a useful information for any party working in field of fishery program. 

Giscience in the Mountain Geography

2010 ◽  
Vol 27 (1-2) ◽  
pp. 81-90
Author(s):  
Krishna Poudel
Keyword(s):  
Spatial Data ◽  
Environmental Data ◽  
Temporal Data ◽  
Observation Systems ◽  
Research Findings ◽  
Temporal And Spatial ◽  
Temporal And Spatial Characteristics ◽  
Mountain Geography ◽  
Different Sources

Mountains have distinct geography and are dynamic in nature compared to the plains. 'Verticality' and 'variation' are two fundamental specificities of the mountain geography. They possess distinct temporal and spatial characteristics in a unique socio-cultural setting. There is an ever increasing need for spatial and temporal data for planning and management activities; and Geo Information (GI) Science (including Geographic Information and Earth Observation Systems). This is being recognized more and more as a common platform for integrating spatial data with social, economic and environmental data and information from different sources. This paper investigates the applicability and challenges of GISscience in the context of mountain geography with ample evidences and observations from the mountain specific publications, empirical research findings and reports. The contextual explanation of mountain geography, mountain specific problems, scientific concerns about the mountain geography, advances in GIScience, the role of GIScience for sustainable development, challenges on application of GIScience in the contexts of mountains are the points of discussion. Finally, conclusion has been made with some specific action oriented recommendations.

Sharing Seoul: Appropriating Alleys as Communal Space through Localized Sharing Practices

2020 ◽  
Vol 46 (1) ◽  
pp. 99-114
Author(s):  
Im Sik Cho ◽  
Blaž Križnik
Keyword(s):  
Community Engagement ◽  
Public Space ◽  
Social Relationship ◽  
Spatial Dimension ◽  
Urban Life ◽  
Communal Life ◽  
Relationship Networks ◽  
Research Findings ◽  
Communal Space

Sharing practices are an important part of urban life. This article examines the appropriation of alleys as communal space to understand how sharing practices are embedded in localities, how communal space is constituted and maintained, and how this sustains communal life. In this way, the article aims to understand the spatial dimension of sharing practices, and the role of communal space in strengthening social relationship networks and urban sustainability. Seowon Maeul and Samdeok Maeul in Seoul are compared in terms of their urban regeneration approaches, community engagement in planning, street improvement, and the consequences that the transformation had on the appropriation of alleys as communal space. The research findings show that community engagement in planning is as important as the provision of public space if streets are to be appropriated as communal space. Community engagement has changed residents' perception and use of alleys as a shared resource in the neighbourhood by improving their capacity to act collectively and collaborate with other stakeholders in addressing problems and opportunities in cities.

The emerging role of COX-2, 15-LOX, and PPARγ in metabolic diseases and cancer: An introduction to novel multi-target directed ligands (MTDLs)

2020 ◽  
Vol 27 ◽  
Author(s):  
Rana A. Alaaeddine ◽  
Perihan A. Elzahhar ◽  
Ibrahim AlZaim ◽  
Wassim Abou-Kheir ◽  
Ahmed S.F. Belal ◽  
...  
Keyword(s):  
Metabolic Diseases ◽  
Biological Effects ◽  
Arachidonic Acid Metabolism ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Cellular Targets ◽  
Design And Synthesis ◽  
Early Results ◽  
Cox 2

: Emerging evidence supports an intertwining framework for the involvement of different inflammatory pathways in a common pathological background for a number of disorders. Of importance are pathways involving arachidonic acid metabolism by cyclooxygenase-2 (COX-2) and 15-lipoxygenase (15-LOX). Both enzyme activities and their products are implicated in a range of pathophysiological processes encompassing metabolic impairment leading to adipose inflammation and the subsequent vascular and neurological disorders, in addition to various pro-and anti-tumorigenic effects. A further layer of complexity is encountered by the disparate, and often reciprocal, modulatory effect COX-2 and 15-LOX activities and metabolites exert on each other or on other cellular targets, the most prominent of which is peroxisome proliferator-activated receptor gamma (PPARγ). Thus, effective therapeutic intervention with such multifaceted disorders requires the simultaneous modulation of more than one target. Here, we describe the role of COX-2, 15-LOX, and PPARγ in cancer and complications of metabolic disorders, highlight the value of designing multi-target directed ligands (MTDLs) modifying their activity, and summarize the available literature regarding the rationale and feasibility of design and synthesis of these ligands together with their known biological effects. We speculate on the potential impact of MTDLs in these disorders as well as emphasize the need for structured future effort to translate these early results facilitating the adoption of these, and similar, molecules in clinical research.

Non-pharmacological Strategies Against Systemic Inflammation: Molecular Basis and Clinical Evidence

2020 ◽  
Vol 26 (22) ◽  
pp. 2620-2629 ◽  
Author(s):  
Rita Del Pinto ◽  
Davide Pietropaoli ◽  
Annalisa Monaco ◽  
Giovambattista Desideri ◽  
Claudio Ferri ◽  
...  
Keyword(s):  
Human Genome ◽  
Systemic Inflammation ◽  
Clinical Evidence ◽  
Metabolic Diseases ◽  
Lifestyle Changes ◽  
Common Denominator ◽  
Active Lifestyle ◽  
Systemic Impact ◽  
Public Health Strategies

Systemic inflammation is a common denominator to a variety of cardiovascular (CV) and non-CV diseases and relative risk factors, including hypertension and its control, metabolic diseases, rheumatic disorders, and those affecting the gastrointestinal tract. Besides medications, a non-pharmacological approach encompassing lifestyle changes and other complementary measures is mentioned in several updated guidelines on the management of these conditions. We performed an updated narrative review on the mechanisms behind the systemic impact of inflammation and the role of non-pharmacological, complementary measures centered on lowering systemic phlogosis for preserving or restoring a good global health. The central role of genetics in shaping the immune response is discussed in conjunction with that of the microbiome, highlighting the interdependence and mutual influences between the human genome and microbial integrity, diversity, and functions. Several plausible strategies to modulate inflammation and restore balanced crosstalk between the human genome and the microbiome are then recapitulated, including dietary measures, active lifestyle, and other potential approaches to manipulate the resident microbial community. To date, evidence from high-quality human studies is sparse to allow the unconditioned inclusion of understudied, though plausible solutions against inflammation into public health strategies for global wellness. This gap claims further focused, well-designed research targeted at unravelling the mechanisms behind future personalized medicine.

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