scholarly journals Faecal microbiota transplantation: a review

2020 ◽  
Vol 41 (2) ◽  
pp. 65
Author(s):  
Holly A Sinclair ◽  
Paul Chapman
Keyword(s):  
Adverse Events ◽  
Healthy Donor ◽  
Donor Selection ◽  
Faecal Microbiota ◽  
Human Faeces ◽  
Faecal Microbiota Transplantation ◽  
Gut Dysbiosis ◽  
Clostridioides Difficile ◽  
Clostridioides Difficile Infection

Faecal microbiota transplantation (FMT) is the transfer of human faeces from a healthy donor to a recipient with a disease associated with gut dysbiosis. Here we review faecal microbiota transplantation as a treatment for Clostridioides difficile infection (CDI) and other conditions including decolonisation of multiresistant organisms. Donor selection and screening, adverse events, processing, administration and regulation of FMT are discussed.

scholarly journals Faecal microbiota transplantation for recurrent Clostridioides difficile infection: An updated systematic review and meta-analysis

2020 ◽  
Vol 29-30 ◽  
pp. 100642
Author(s):  
Simon Mark Dahl Baunwall ◽  
Mads Ming Lee ◽  
Marcel Kjærsgaard Eriksen ◽  
Benjamin H. Mullish ◽  
Julian R. Marchesi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Faecal Microbiota ◽  
Faecal Microbiota Transplantation ◽  
Clostridioides Difficile ◽  
Clostridioides Difficile Infection

scholarly journals Faecal transplantation and Clostridioides difficile infection

2021 ◽  
Vol 52 (3) ◽  
pp. 215-223
Author(s):  
Darija Knežević ◽  
Miroslav Petković
Keyword(s):  
Public Health ◽  
Intestinal Microbiota ◽  
Healthy Donor ◽  
Intestinal Microflora ◽  
Anaerobic Bacteria ◽  
Antibiotic Consumption ◽  
Faecal Microbiota ◽  
Clostridioides Difficile ◽  
Clostridioides Difficile Infection ◽  
Faecal Suspension

Faecal microbiota transplantation (FMT), known equally well as faecal transplantation or faecal bacteriotherapy, is the process of implanting the faecal suspension containing balanced microbiota from a healthy donor to the colon of a recipient patient. Excessive growth of Clostridioides difficile (C difficile) in the intestinal microbiota resulting from antibiotic consumption is currently a rising threat to public health. FMT is one of the most important, newer approaches to treating C difficile infections. Since C difficile is regarded as an opportunistic bacterium triggering disease in conditions of disturbed homeostasis of the intestinal microbiota, restoration of healthy intestinal microflora facilitates suppression of toxic strain of C difficile by anaerobic bacteria of normal intestinal microflora with concomitant cure. Nurses have important role in caring for patients after faecal transplantation.

scholarly journals Faecal microbiota transplantation in Clostridioides difficile infection: real-life experience from an academic Italian hospital

2020 ◽  
Vol 13 ◽  
pp. 175628482093431
Author(s):  
Brigida Barberio ◽  
Sonia Facchin ◽  
Edoardo Mele ◽  
Renata D’Incà ◽  
Giacomo Carlo Sturniolo ◽  
...  
Keyword(s):  
Therapeutic Option ◽  
Laboratory Data ◽  
Real Life ◽  
Collagenous Colitis ◽  
Faecal Microbiota ◽  
Effective Treatment Option ◽  
Faecal Microbiota Transplantation ◽  
Clostridioides Difficile ◽  
Clostridioides Difficile Infection

Background: Faecal microbiota transplantation (FMT) is a reasonable therapeutic option for the treatment of Clostridioides difficile infection (CDI) recurrent and refractory (RCDI) to therapy, but little evidence on the long-term impact of this therapy is currently available in the literature. The aim of this study was to evaluate the efficacy and safety of FMT in recurrent and refractory CDI and the modifications of the recipient’s gut microbiota in the medium–long term. Methods: This prospective study collects the clinical and laboratory data of RCDI patients treated with FMT by colonoscopy from February 2016 to October 2019. Stool samples for metagenomic analysis were collected pre-FMT at 1 week and at 6 and 12–24 months post-FMT. Results: In the study period, 20 FMT procedures were performed on 19 patients. Overall, FMT was effective in 85% of treated patients. No serious adverse event was recorded. In the medium- to long-term follow up, a newly diagnosed case of collagenous colitis was observed. Post-FMT, significant changes in microbiota were observed, characterised by the transition from a low- to a greater-diversity profile. Therefore, FMT restores eubiosis and maintains it over time. Conclusion: FMT is a safe and effective treatment option in RCDI patients. This procedure induces profound microbiota changes that explain its high clinical efficacy.

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