scholarly journals Fast tracking drug development: balancing risks and rewards

2002 ◽  
Vol 23 (5) ◽  
pp. 20
Author(s):  
Harry Majewski
Keyword(s):  
Drug Design ◽  
Drug Development ◽  
High Throughput ◽  
Combinatorial Chemistry ◽  
High Throughput Screening ◽  
Target Discovery ◽  
New Therapies ◽  
Fast Tracking ◽  
Great Hope

The biotechnology revolution offers great hope for new therapies based on rational approaches to target discovery and drug design based on genomics, proteomics, advanced chemistry (3-D modelling, combinatorial chemistry) and high throughput screening.

scholarly journals High-Throughput Screening and Drug Development to Fix RyR Pathology

2021 ◽  
Vol 120 (3) ◽  
pp. 148a-149a
Author(s):  
Robyn T. Rebbeck ◽  
Kaja Rozman ◽  
Gabrielle M. Evans ◽  
Jacob Schwarz ◽  
Marzena Baran ◽  
...  
Keyword(s):  
Drug Development ◽  
High Throughput ◽  
High Throughput Screening

scholarly journals Improved method of structure-based virtual screening based on ensemble learning

RSC Advances ◽  
2020 ◽  
Vol 10 (13) ◽  
pp. 7609-7618
Author(s):  
Jin Li ◽  
WeiChao Liu ◽  
Yongping Song ◽  
JiYi Xia
Keyword(s):  
Virtual Screening ◽  
Drug Design ◽  
Ensemble Learning ◽  
High Throughput ◽  
High Throughput Screening ◽  
Screening Method ◽  
Improved Method ◽  
Complementary Technique

Virtual screening has become a successful alternative and complementary technique to experimental high-throughput screening technologies for drug design. This paper proposed a target-specific virtual screening method based on ensemble learning named ENS-VS.

scholarly journals Selected Approaches for Rational Drug Design and High Throughput Screening to Identify Anti-Cancer Molecules

2012 ◽  
Vol 12 (9) ◽  
pp. 1143-1155 ◽  
Author(s):  
Michael Hedvat ◽  
Luni Emdad ◽  
Swadesh K. Das ◽  
Keetae Kim ◽  
Santanu Dasgupta ◽  
...  
Keyword(s):  
Drug Design ◽  
High Throughput ◽  
High Throughput Screening ◽  
Rational Drug Design ◽  
Rational Drug ◽  
Anti Cancer

Development of Combinatorial Chemistry Methods for Coatings:  High-Throughput Screening of Abrasion Resistance of Coatings Libraries

2002 ◽  
Vol 74 (19) ◽  
pp. 5105-5111 ◽  
Author(s):  
Radislav A. Potyrailo ◽  
Bret J. Chisholm ◽  
Daniel R. Olson ◽  
Michael J. Brennan ◽  
Chris A. Molaison
Keyword(s):  
High Throughput ◽  
Combinatorial Chemistry ◽  
Abrasion Resistance ◽  
High Throughput Screening

scholarly journals The Effects of Combinatorial Chemistry and Technologies on Drug Discovery and Biotechnology – a Mini Review

2014 ◽  
Vol 13 (2) ◽  
pp. 87-108 ◽  
Author(s):  
Pierfausto Seneci ◽  
Giorgio Fassina ◽  
Vladimir Frecer ◽  
Stanislav Miertus
Keyword(s):  
Drug Discovery ◽  
Drug Design ◽  
Expert Opinion ◽  
High Throughput ◽  
Combinatorial Chemistry ◽  
Rational Design ◽  
Combinatorial Libraries ◽  
Computer Assisted ◽  
Future Trends ◽  
The Impact

Abstract The review will focus on the aspects of combinatorial chemistry and technologies that are more relevant in the modern pharmaceutical process. An historical, critical introduction is followed by three chapters, dealing with the use of combinatorial chemistry/high throughput synthesis in medicinal chemistry; the rational design of combinatorial libraries using computer-assisted combinatorial drug design; and the use of combinatorial technologies in biotechnology. The impact of “combinatorial thinking” in drug discovery in general, and in the examples reported in details, is critically discussed. Finally, an expert opinion on current and future trends in combinatorial chemistry and combinatorial technologies is provided.

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