UV-induced photodegradation of oseltamivir (Tamiflu) in water

2011 ◽  
Vol 8 (2) ◽  
pp. 182 ◽  
Author(s):  
Alfred Y. C. Tong ◽  
Rhiannon Braund ◽  
Eng W. Tan ◽  
Louis A. Tremblay ◽  
Tristan Stringer ◽  
...  
Keyword(s):  
High Performance ◽  
Advanced Oxidation Processes ◽  
Treatment Options ◽  
Antiviral Drug ◽  
Advanced Oxidation ◽  
Degradation Process ◽  
Order Rate Constant ◽  
Sewage Water ◽  
Oxidation Processes ◽  
First Order

Environmental contextOseltamivir (Tamiflu) is widely used to prevent and treat influenza but conventional wastewater processes involving sedimentation and biotic oxidation do not appear to significantly remove it from sewage, leading to its discharge into the environment. A range of advanced oxidation processes (AOPs) involving photolysis of aqueous solutions of oseltamivir with UV alone, UV/H2O2 and UV/H2O2/FeII is demonstrated to lead to photodegradation of oseltamivir to products with no ecotoxicity observed. These AOPs may therefore offer potentially environmentally friendly sewage water treatment options. AbstractAqueous solutions of the antiviral drug oseltamivir phosphate (OSP, Tamiflu, (3R,4R,5S)-ethyl 4-acetamido-5-amino-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate) were degraded using advanced oxidation processes (AOPs) involving photodegradation with UV alone, UV/H2O2 and UV/H2O2/FeII (photo-Fenton reaction). The photodecay of the parent OSP in all three cases followed first-order kinetics with respective rate constants of 0.21, 1.56 and 1.75 min–1 at 20°C in pH 7 phosphate-buffered Milli-Q water. The rate of UV/H2O2 photolysis in the presence of 2-methylpropan-2-ol was significantly slower with an approximate first-order rate constant of 0.13 min–1 suggesting the involvement of •OH in the degradation process. NMR spectroscopy, mass spectrometry and high-performance liquid chromatography (HPLC) with UV diode array detection were used to identify the crude photoproduct as the hydroxylated OSP derivative (3S,4R,5S)-ethyl 4-acetamido-5-amino-2-hydroxy-3-(pentan-3-yloxy)cyclohexanecarboxylate that occurs by an unknown mechanism. OSP and this crude photoproduct demonstrated no effect on the survival of Quinquelaophonte sp. over 96 h.

scholarly journals Degradation of the pharmaceuticals lamivudine and zidovudine using advanced oxidation processes

2020 ◽  
Vol 42 ◽  
pp. e9
Author(s):  
Alex Leandro Andrade de Lucena ◽  
Daniella Carla Napoleão ◽  
Hélder Vinícius Carneiro da Silva ◽  
Rayany Magali da Rocha Santana ◽  
Beatriz Galdino Ribeiro ◽  
...  
Keyword(s):  
Lactuca Sativa ◽  
Advanced Oxidation Processes ◽  
Advanced Oxidation ◽  
Kinetic Studies ◽  
Degradation Process ◽  
Oxidation Processes ◽  
First Order ◽  
Input Variables ◽  
Pharmaceutical Degradation ◽  
Uv C

The existence of pharmaceuticals in nature is a growing environmental problem, turning necessary the use of efficient treatments for the degradation of these substances, as the advanced oxidation processes (AOPs). In this work the AOPs UV/H2O2 and photo-Fenton were applied to degrade the pharmaceuticals lamivudine and zidovudine in an aqueous solution using a bench reactor, composed of three UV-C lamps. It was verified that the UV/H2O2 process presented a degradation of 97.33 ± 0.14% for lamivudine and 93.90 ± 0.33% for zidovudine, after 180 min of treatment and for an initial concentratin of each pharmaceutical of  5 mg.L-1 and [H2O2] of 600 mg.L-1.  A methodology by artificial neural networks (ANNs) was used to model the photocatalytic process, with the MLP 7-23-2 ANN representing it well, and determining the relative importance (%) of each of the input variables for the pharmaceutical’s degradation process. Kinetic studies for the pharmaceutical degradation and the conversion of organic matter showed good adjustments to the pseudo first-order models with R2 raging from 0.9705 to 0.9980. Toxicity assays for the before treatment solution indicated that the seeds Lactuca sativa and Portulaca grandiflora showed growth inhibition whereas the post-treatment solution inhibited only the growth of Lactuca sativa.

scholarly journals Degradation of the pharmaceuticals lamivudine and zidovudine using advanced oxidation processes

2020 ◽  
Vol 42 ◽  
pp. e30
Author(s):  
Alex Leandro Andrade de Lucena ◽  
Daniella Carla Napoleão ◽  
Hélder Vinícius Carneiro da Silva ◽  
Rayany Magali Da Rocha Santana ◽  
Beatriz Galdino Ribeiro ◽  
...  
Keyword(s):  
Lactuca Sativa ◽  
Advanced Oxidation Processes ◽  
Advanced Oxidation ◽  
Kinetic Studies ◽  
Degradation Process ◽  
Oxidation Processes ◽  
First Order ◽  
Input Variables ◽  
Pharmaceutical Degradation ◽  
Uv C

The existence of pharmaceuticals in nature is a growing environmental problem, turning necessary the use of efficient treatments for the degradation of these substances, as the advanced oxidation processes (AOPs). In this work the AOPs UV/H2O2 and photo-Fenton were applied to degrade the pharmaceuticals lamivudine and zidovudine in an aqueous solution using a bench reactor, composed of three UV-C lamps. It was verified that the UV/H2O2 process presented a degradation of 97.33 ± 0.14% for lamivudine and 93.90 ± 0.33% for zidovudine, after 180 min of treatment and for an initial concentratin of each pharmaceutical of  5 mg.L-1 and [H2O2] of 600 mg.L-1.  A methodology by artificial neural networks (ANNs) was used to model the photocatalytic process, with the MLP 7-23-2 ANN representing it well, and determining the relative importance (%) of each of the input variables for the pharmaceutical’s degradation process. Kinetic studies for the pharmaceutical degradation and the conversion of organic matter showed good adjustments to the pseudo first-order models with R2 raging from 0.9705 to 0.9980. Toxicity assays for the before treatment solution indicated that the seeds Lactuca sativa and Portulaca grandiflora showed growth inhibition whereas the post-treatment solution inhibited only the growth of Lactuca sativa.

scholarly journals Evaluation of the degradation potential of different advanced oxidation processes for a textile dye mixture: a kinetic study with mathematical modeling and toxicological tests

2020 ◽  
Vol 42 ◽  
pp. e7
Author(s):  
Joanna Cysneiros Silva ◽  
Rayany Magali da Rocha Santana ◽  
Graziele Elisandra do Nascimento ◽  
Alex Leandro Andrade de Lucena ◽  
Ana Maria Ribeiro Bastos da Silva ◽  
...  
Keyword(s):  
Advanced Oxidation Processes ◽  
Treatment Process ◽  
Wastewater Treatment Plants ◽  
Advanced Oxidation ◽  
Textile Dye ◽  
Rapid Decay ◽  
Oxidation Processes ◽  
First Order ◽  
Heterogeneous Processes ◽  
Brazilian Northeast

Studies and research have been developed around the world on environmental pollution. Among the most diverse types of pollutants, textile dyes have attracted attention in the Brazilian Northeast. These compounds, besides being persistent, resist to the conventional treatments applied in the wastewater treatment plants. Thus, the present study evaluated the degradation of the mixture of direct red 23, direct red 227 and direct orange 26 dyes by advanced oxidation processes (AOPs). It was observed that the homogeneous AOPs were more efficient, being able to degrade 100% of the chromophoric groups after the optimization of the variables [H2O2], [Fe] and pH. The reaction kinetics for the photo-Fenton process followed a pseudo-first order non-linear model, with rapid decay of the concentrations in the first 60 min. Aiming to have a methodology capable of predicting the degradation efficiency for the studied processes, it was verified that the artificial neural networks MLP 4-9-3 and MLP 5-6-3 well represent the data from the homogeneous and heterogeneous processes, respectively. A toxicity study was carried out using seeds, bacteria and microcrustaceans and it was found that the intermediate compounds formed during the treatment process act differently for each of them.

Degradation of propoxycarbazone-sodium with advanced oxidation processes

2011 ◽  
Vol 11 (1) ◽  
pp. 129-134 ◽  
Author(s):  
A. Dulov ◽  
N. Dulova ◽  
Y. Veressinina ◽  
M. Trapido
Keyword(s):  
Rate Constants ◽  
Advanced Oxidation Processes ◽  
Advanced Oxidation ◽  
Fenton Process ◽  
Oxidation Processes ◽  
First Order ◽  
Order Rate ◽  
Conversion Time ◽  
Pseudo First Order ◽  
Kinetics Of

The degradation of propoxycarbazone-sodium, an active component of commercial herbicide, in aqueous solution with ozone, UV photolysis and advanced oxidation processes: O3/UV, O3/UV/H2O2, H2O2/UV, and the Fenton process was studied. All these methods of degradation proved feasible. The kinetics of propoxycarbazone-sodium degradation in water followed the pseudo-first order equation for all studied processes except the Fenton treatment. The application of schemes with ozone demonstrated low pseudo-first order rate constants within the range of 10−4 s−1. Addition of UV radiation to the processes improved the removal of propoxycarbazone-sodium and increased the pseudo-first order rate constants to 10−3 s−1. The Fenton process was the most efficient and resulted in 5 and 60 s of half-life and 90% conversion time of propoxycarbazone-sodium, respectively, at 14 mM H2O2 concentration. UV treatment and the Fenton process may be recommended for practical application in decontamination of water or wastewater.

scholarly journals Electrochemical Hydrogen Peroxide Production in Acidic Medium Using a Tubular Photo-reactor: Application in Advanced Oxidation Processes

2017 ◽  
Vol 58 (3) ◽  
Author(s):  
Juan M. Peralta-Hernández ◽  
Luis A. Godínez
Keyword(s):  
Hydrogen Peroxide ◽  
Acidic Medium ◽  
High Performance ◽  
Advanced Oxidation Processes ◽  
Advanced Oxidation ◽  
Electrochemical Reactor ◽  
Coliform Bacteria ◽  
Carbon Cloth ◽  
Oxidation Processes ◽  
Electrochemical Advanced Oxidation Processes

<p>This paper describes the results obtained in the design and characterization of a tubular electrochemical reactor. The set-up was employed for on-site hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) production in an acidic medium (pH 3) to promote three electrochemical advanced oxidation processes (EAOP): electro-Fenton (EF), photoelectro-Fenton (PEF) and photocatalysis treatment (PT). These processes were evaluated by their abilities to degrade a commercial dye, Orange-II (OGII), in solution using total organic carbon (TOC) removal and high performance liquid chromatography (HPLC). To have free solutions of iron in the EF and PEF systems, a Nafion<sup>TM</sup> membrane with dispersed iron was prepared. For use in photocatalysis, electrodes with a large superficial area were prepared by coating carbon cloth fiber supports with titanium dioxide (TiO<sub>2</sub>) using the electrophoretic (EP) method. In this work, wastewater samples with a large number of microorganisms (coliform bacteria) were treated with this new reactor design.</p>

Advanced Oxidation Processes for Dye Removal From Wastewater

2020 ◽  
pp. 205-238 ◽  
Author(s):  
Victor Odhiambo Shikuku ◽  
Wilfrida N. Nyairo
Keyword(s):  
Electrochemical Oxidation ◽  
Reaction Mechanisms ◽  
Advanced Oxidation Processes ◽  
Dye Removal ◽  
Treatment Options ◽  
Advanced Oxidation ◽  
Factors Affecting ◽  
Oxidation Processes ◽  
Potential Alternative ◽  
Alternative Techniques

Advanced oxidation processes (AOPs), namely the Fenton oxidation, ozonation, electrochemical oxidation, and photocatalysis, are potential alternative techniques for dye removal from textile effluents. Their inherent ability to completely mineralize pollutants including those recalcitrant to biodegradation and to be compatibly integrated in conventional technologies present grounds for consideration of AOPs as alternative wastewater treatment options. Advanced oxidation involves generation and subsequent reaction of various radicals and reacting species with the target compounds. This chapter discusses the fundamentals and chemistry and efficiencies of the Fenton process, ozonation, electrochemical oxidation, and photocatalysis processes for complete dye removal from wastewater. The reaction mechanisms, performance, and factors affecting efficiency are discussed.

Parameters controlling the advanced oxidation degradation kinetics of nitroglycerin and pentaerythritol tetranitrate

2018 ◽  
Vol 7 (1) ◽  
pp. 61-67
Author(s):  
Do Ngoc Khue ◽  
Tran Dai Lam ◽  
Dao Duy Hung ◽  
Vu Quang Bach ◽  
Nguyen Van Anh ◽  
...  
Keyword(s):  
Advanced Oxidation Processes ◽  
Degradation Kinetics ◽  
Advanced Oxidation ◽  
Reaction Rates ◽  
Pentaerythritol Tetranitrate ◽  
Order Model ◽  
Oxidation Processes ◽  
First Order ◽  
Oxidation Degradation ◽  
Kinetics Of

AbstractSeveral advanced oxidation processes have been performed for the decomposition of ester nitrates (ENs), such as nitroglycerine (NG) and pentaerythritol tetranitrate (PETN). The reaction kinetics for removing NG and PETN by some of the advanced oxidation processes (e.g. UV-H2O2, Fenton, UV-Fenton) followed the pseudo-first-order model. The reaction rates in different systems followed the sequence ENs/UV<ENs/H2O2<ENs/UV-H2O2<ENs/Fenton<ENs/UV-Fenton. The effect of various parameters, such as pH, concentration of hydrogen peroxide, and temperature, on the degradation of NG and PETN were studied.

scholarly journals Photo-Fenton and Fenton Oxidation of Recalcitrant Industrial Wastewater Using Nanoscale Zero-Valent Iron

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Henrik Hansson ◽  
Fabio Kaczala ◽  
Marcia Marques ◽  
William Hogland
Keyword(s):  
Advanced Oxidation Processes ◽  
Treatment Options ◽  
Advanced Oxidation ◽  
Zero Valent Iron ◽  
Process Industries ◽  
Dry Process ◽  
Oxidation Processes ◽  
Wood Floor ◽  
Positive Effects ◽  
Nanoscale Zero Valent Iron

There is a need for the development of on-site wastewater treatment technologies suitable for “dry-process industries,” such as the wood-floor sector. Due to the nature of their activities, these industries generate lower volumes of highly polluted wastewaters after cleaning activities. Advanced oxidation processes such as Fenton and photo-Fenton, are potentially feasible options for treatment of these wastewaters. One of the disadvantages of the Fenton process is the formation of large amounts of ferrous iron sludge, a constraint that might be overcome with the use of nanoscale zero-valent iron (nZVI) powder. Wastewater from a wood-floor industry with initial COD of 4956 mg/L and TOC of 2730 mg/L was treated with dark-Fenton (nZVI/H2O2) and photo-Fenton (nZVI/H2O2/UV) applying a 2-level full-factorial experimental design. The highest removal of COD and TOC (80% and 60%, resp.) was achieved using photo-Fenton. The supply of the reactants in more than one dose during the reaction time had significant and positive effects on the treatment efficiency. According to the results, Fenton and mostly photo-Fenton are promising treatment options for these highly recalcitrant wastewaters. Future investigations should focus on optimizing treatment processes and assessing toxic effects that residual pollutants and the nZVI might have. The feasibility of combining advanced oxidation processes with biological treatment is also recommended.

scholarly journals Kinetics and Mechanistic Studies of Photochemical and Oxidative Stability of Galaxolide

Water ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 1813
Author(s):  
Aneta Sokol ◽  
Artur Ratkiewicz ◽  
Iwona Tomaszewska ◽  
Joanna Karpinska
Keyword(s):  
Advanced Oxidation Processes ◽  
Degradation Products ◽  
Advanced Oxidation ◽  
Degradation Process ◽  
Oh Radicals ◽  
Direct Photolysis ◽  
Oxidation Processes ◽  
First Order Kinetics ◽  
Kinetics Of ◽  
Oxidative Agents

Studies on kinetics of galaxolide (HHCB) degradation under influence of UV, simulated sunlight and some advanced oxidation processes (H2O2, UV/H2O2, and Vis/H2O2) were conducted. Galaxolide appeared to be a photolabile compound. The first-order kinetics model was assumed for all studied processes. It was observed that basic pH favored HHCB degradation. The influence of natural matrices (river water and artificial sweat) on direct photolysis of HHCB was examined. It was stated that the process of the photodegradation proceeded slower at the presence of each matrix. HHCB lactone was identified using the GC-MS technique. The recorded chromatograms showed that apart from the lactone, other degradation products were formed that we could not identify. In order to deeper understand the HHCB degradation process, DFT calculations were performed. The results pointed out that OH radicals play a key role in HHCB decomposition, which mainly proceeds via H abstractions as well as OH additions. It follows from the calculations that the visible light is sufficient to initiate the advanced oxidation processes (AOPs) under the oxidative conditions, whereas UV irradiation is needed to start decay with no oxidative agents.

scholarly journals Oxidación electroquímica para la degradación de ciprofloxacíno asistida con radiación ultravioleta utilizando ánodos dimensionalmente estables

2020 ◽  
Author(s):  
◽  
Angel Eduardo Yañez Rios
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Organic Carbon ◽  
Total Organic Carbon ◽  
High Performance ◽  
Advanced Oxidation Processes ◽  
Advanced Oxidation ◽  
Visible Spectroscopy ◽  
Oxidation Processes ◽  
Dimensionally Stable Anode

Numerosos reportes han descrito un aumento de los productos farmacéuticos y de cuidado personal, detectados en diversos cuerpos de agua durante los últimos años. Su continua detección es un riesgo, ya que puede significar una afectación directa hacia el ecosistema. La presencia de este tipo de contaminantes en efluentes de plantas de tratamiento de aguas residuales, demuestran las bajas eficiencias de degradación por los métodos convencionales. Debido a lo anterior, alternativas como los procesos de oxidación avanzada (AOPs, Advanced Oxidation Processes) han ganado interés, por la producción de especies oxidantes capaces de degradar compuestos altamente recalcitrantes. El acoplar dos o más AOPs, puede favorecer el aumento en la producción de agentes oxidantes (HOCl, .OH), así como incrementar la eficiencia de degradación y mineralización de contaminantes. Con este último propósito, se realizó la degradación de ciprofloxacino (20 ppm) al implementar un sistema electroquímico foto-asistido, donde se utilizó un electrodo de RuO2 como ánodo dimensionalmente estable (DSA, Dimensionally Stable Anode), sintetizado mediante el método de Pechini, en conjunto con una fuente de radiación de 254 nm y soluciones de 0.05M de NaCl como fuente de cloruros. Además, se estudió el comportamiento del sistema foto-electrocatalítico en condiciones de pH 3, 6 y 9, con ayuda de la imposición de densidades de corriente de 5 y 10 mA cm−2, ocurriendo entonces, la electrogeneración de especies de cloro activo, así como reacciones de homólisis de las mismas para la degradación del ciprofloxacino. Los productos de los sistemas se evaluaron por medio de espectroscopía UV (UV-Vis, Ultraviolet-Visible Spectroscopy), cromatografía de líquidos de alta resolución (HPLC, High Performance Liquid Chromatography) y carbono orgánico total (TOC, Total Organic Carbon). Los resultados indicaron mayor eficiencia durante el proceso a condiciones de pH 6 e imposición de 10 mA cm-2, obteniendo una mineralización promedio del 69.4±5.6%, del contaminante a 60 minutos, mientras que la degradación del contaminante ocurrió durante los primeros 5 minutos del proceso.

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