Internal phosphorus requirements of six legumes and two grasses

1994 ◽  
Vol 34 (3) ◽  
pp. 373 ◽  
Author(s):  
A Pinkerton ◽  
PJ Randall
Keyword(s):  
Field Experiments ◽  
Early Stage ◽  
Sand Culture ◽  
Published Data ◽  
P Deficiency ◽  
Critical Concentrations ◽  
Phosphate Fertiliser ◽  
Full Flowering ◽  
Lotus Pedunculatus ◽  
Phosphorus Requirements

Critical phosphorus (P) values, both total (P,) and inorganic Pi, for the diagnosis of P deficiency were derived for a number of pasture species that are increasingly used in Australia. Trifolium balansae and Medicago murex, with T. subterraneum for comparison, were grown for 2 seasons in field experiments to which 7 rates of phosphate fertiliser were applied. The legumes T. balansae, M. murex, M. polymorpha, Ornithopus compressus, and Lotus pedunculatus, and the grasses Phalaris aquatica and Danthonia richardsonii, were grown in sand culture in glasshouse experiments and provided with nutrient solutions containing 6 rates of P (0.05-1.6 mmol/L). Diagnostic indices were derived for blades of the youngest open leaves (YOL) or youngest expanded blades, and for whole shoots. Critical Pt concentration in the YOL of T. balansae did not decline until full flowering and was the most stable indicator. The range of critical concentrations was 0.45-0.50% for both diagnosis of deficiency and prediction of seasonal yield. A Pi concentration of 150 mg/kg was critical for T. balansae during vegetative growth only. Critical concentrations in M. murex declined from an early stage, but a Pt concentration in YOL of 0.40% was the most useful indicator for diagnosis until flowering. The critical values for T. subterraneum agreed well with previously published data. Critical P concentrations in O. compressus were similar at 2 sampling times. For the remaining species, critical concentrations declined with time and it was necessary to know plant age when interpreting them.

scholarly journals Relationships of Gibberellic Acid to Water and Phosphorus in the Growth, Sugar Production, and Enzyme Behavior of Sugarcane

1969 ◽  
Vol 53 (3) ◽  
pp. 149-166
Author(s):  
Alex G. Alexander
Keyword(s):  
Gibberellic Acid ◽  
Water Supply ◽  
Field Experiments ◽  
Maximum Growth ◽  
Sand Culture ◽  
Growth Responses ◽  
P Deficiency ◽  
P Content ◽  
Variable Water ◽  
P Supply

Immature sugarcane was subjected to variable water and phosphorus (P) supply and then treated with foliar gibberellic acid (GA). All plants were grown in sand culture and received initial water and P treatments at 88 days of age. Water regimes of inadequate, adequate, and abundant supply were established with 1, 2, and 4 liters of water per day, respectively. Variable P included 0, 6, and 30 meq./liter. Foliar GA was given as 0-, 0.01-, and 0.10-percent solutions. There were three objectives: 1 To determine the effectiveness of GA as a growth stimulant and regulator of sugar-enzyme relationships under conditions of water and P stress; 2, to explore physiological limits within which GA-enzyme relationships persist; and 3, to explore the enzyme basis of water and P performance under extreme conditions of GA-stimulated growth. The following results were recorded: 1. Both water and GA had greatly increased stalk weight and intemode length 5 weeks after GA treatment. 2. Water supply strongly affected GA-growth responses. Water-deficient plants were proportionately more stimulated by GA than water-rich plants. However, maximum growth required both GA and abundant water. 3. GA appeared to increase the efficiency of water utilization, regardless of the amount of water supplied. 4. Variable water supply severely transformed the behavior patterns of ATP-ase, amylase, invertase and polyphenol oxidase. 5. GA treatment of low-water plants appeared to increase the severity of water shortage. Hydrolytic enzymes were severely retarded by GA when water supply was low, but not when adequate or abundant water was available. On the basis of growth and enzyme data it was proposed that GA caused an internal redeployment of water so that the net quantity available for enzymatic functions was reduced. It was also proposed that GA might decrease the internal water supply while increasing growth, in contrast to the commercial practice of externally withholding water which decreases growth. 6. Low P was inadequate for maximum growth, but severe P deficiency was not achieved. GA was proportionally more effective in promoting fresh weights and internode elongation when P supply was low. 7. GA moderately increased leaf P content when P supply was low. The increase was primarily organic P (PO) and this was attributed to GA suppression of phosphatase and ATP-ase. The significance of GA alteration of PO is discussed. 8. Evidence was found of a GA-induced PO decline mediated by increased amylase activity. 9. Leaf peroxidase was extremely sensitive to P supply, and to GA in P-hungry plants. The enzyme was excessively active in low-P X low-GA plants. 10. It is shown that cane growth and enzymology is far more sensitive to P than field experiments have indicated. The importance of PO, phosphatases and phosphorylase, as contrasted to total P content, is stressed.

Sulfur requirements during early growth of Trifolium balansae, Trifolium subterraneum, Medicago murex, and Phalaris aquatica

1995 ◽  
Vol 35 (2) ◽  
pp. 199 ◽  
Author(s):  
A Pinkerton ◽  
PJ Randall
Keyword(s):  
Subterranean Clover ◽  
Trifolium Subterraneum ◽  
Early Growth ◽  
Critical Values ◽  
Sand Culture ◽  
Published Data ◽  
Phalaris Aquatica ◽  
Critical Concentrations ◽  
Highly Correlated ◽  
Nutrient Solutions

Sulfur (S) requirements for early growth were determined for 3 legumes (Trifolium balansae, T. subterraneum, Medicago murex) and 1 grass (Phalaris aquatica). Plants were grown in sand culture in a glasshouse and supplied with nutrient solutions containing 6 rates of S (1-32 �g/mL). Legumes were supplied with nitrogen (N) at 168 �g/mL, and phalaris with 28 or 168 pg N/mL. Plants were sampled twice, the second sampling coinciding with flowering of the legumes. Diagnostic indices [total S (St), HI-reducible S (sulfate-S), oxidised S (S6+)], and ratios (sulfate-S/St, S6+/St) were derived for whole shoots (WS), youngest open leaves (YOL) of legumes, and youngest expanded blades (YEB) of the grass. The largest responses to S by the legumes were made by balansa clover and murex medic, which both outyielded subterranean clover, but subterranean clover was the most efficient user of S and had the lowest external S requirement. Concentrations of S6+ were always higher than concentrations of sulfate-S, but the 2 were highly correlated and much lower than St. No S fraction or plant part sampled was consistently superior as an indicator of S status. The larger relative increases and sharper breaks in gradient of the relationships between yield and sulfate-S or S6+ compared with St were offset by their greater relative variability. All indices were subject to Piper-Steenbjerg effects, although these did not seriously affect the critical values. Critical values of St and S6+ in YOL, St in WS of balansa clover, and S, and S6+ in WS of subterranean clover changed little up to 60 days after sowing, but it was necessary to know plant age when assessing the S status of murex medic or phalaris. Critical concentrations of S, in phalaris were little affected by N supply, but critical concentrations of sulfate-S and S6+ were higher with 28 than 168 �g N/mL. Critical values for subterranean clover agreed well with previously published data.

Establishment theoretical of recommendation fertilization guide of vegetable crops in Algeria: concept and validation

2015 ◽  
Vol 5 (1) ◽  
pp. 606-620
Author(s):  
Mahtali Sbih ◽  
Zoubeir BENSID ◽  
Zohra BOUNOUARA ◽  
Fouad DJAIZ ◽  
Youcef FERRAG
Keyword(s):  
Soil Fertility ◽  
Field Experiments ◽  
Soil Analysis ◽  
Critical Value ◽  
Yield Response ◽  
Published Data ◽  
Vegetable Crops ◽  
Fertilizer Recommendation ◽  
Continuous Models ◽  
Poor Soil

The goal of fertilization is to meet the nutritional needs of plants by completing the supply of soil nutrients in an economically profitable and environmentally friendly. Achieving on-farm optimum economic crop yields of marketable quality with minimum adverse environmental impact requires close attention to fertilization guide. The recommendations seek to do this by ensuring that the available supply of plant nutrients in soil is judiciously supplemented by additions of nutrients in fertilizers. The objective is that crops must have an adequate supply of nutrients, and many crops show large and very profitable increases in yield from the correct use of fertilizers to supply nutrients. The main objective of this work is to establishing a reference guide of fertilization of vegetable crops and cereal in Algeria. To meet this objective, we have processes in two steps: 1) Establishment of theoretical fertilizer recommendation from international guide of crop fertilization; 2) Validation of these developed theoretical fertilizer recommendation by trials in the fields. Sixteen fertilization guides of vegetable crops from the Canadian provinces (5 guides), USA (10 guides) and countries of northern Europe England (1 guide). Generally, the rating of these recommendation is ranging from poor soil to soil exceedingly rich; however, the numbers of fertility classes are very different. Indeed, Quebec Ontario, Minnesota, Wisconsin New England, Maryland and Kentucky and Florida guides are subdivided into 5 fertility classes, ranging from poor soil to soil exceedingly rich. The recommendation of New Brunswick and Manitoba contain six classes. The recommendation of Michigan, Nova Scotia and England contain 10 and 7 fertility classes respectively. The recommendation fertilizer of New York and New Jersey have 3classes. Unlike the systems of fertilization recommendation mentioned above, the recommendation fertilizer of Pennsylvania is based on continuous models of P, K and contains 34 classes for P and 22 classes K. Then we standardized the P soil analysis with conversion equations (Olsen method) and units of measurement (kg/ha, mg/kg…).Following this procedure we transformed discontinued systems of fertility classes in to continuous models to facilitate comparison between the different fertilization recommendation models in one hand, in other hand to obtain critical value (CV).Finally, we used statistics of the conditional expectation in order to generate the theoretical recommendation fertilization guide of fertilization with 7 fertility classes (VL, L, M, MH, OP, H and VH). The next step was calibrating soil tests against yield responses to applied nutrient in field experiments. A database (not published data) from agriculture and agri-food Canada, were used. Production of pumpkin responded positively and significantly to P or K soil fertility levels, increases being observed with P more often than with K. According to the Cate-Nelson methods, the critical value of Olsen-P in the top 20 cm of soil was about 25 mg/kg: at values of greater than or equal to 25 mg/kg, crops achieved about 80% of their maximal yield in the absence of fertilizer application. The CV of K in soil for this crop was about 140 mg/kg. The CV found was very close to this generated by the theoretical method for recommendation of fertilization guide. Finally, we used the procedure of Cope and Rouse in both sides of the CV in order to make subdivisions of different groups of soil fertility. One calibrates the soil-test value against yield response to tile nutrient to predict fertilizer requirement.

scholarly journals Incorporating biomarkers in ecological risk assessment of chemical contaminants of soils

2007 ◽  
Vol 26 (2) ◽  
pp. 120-137
Author(s):  
A. J. Reinecke ◽  
S. A. Reinecke ◽  
M. S. Maboeta ◽  
J. P. Odendaal ◽  
R. Snyman
Keyword(s):  
Risk Assessment ◽  
South African ◽  
Field Experiments ◽  
Early Stage ◽  
Population Level ◽  
Diagnostic Tools ◽  
Future Research ◽  
Chemical Contaminants ◽  
Toxic Response ◽  
Future Research Directions

Soil is an important but complex natural resource which is increasingly used as sink for chemicals. The monitoring of soil quality and the assessment of risks posed by contaminants have become crucial. This study deals with the potential use of biomarkers in the monitoring of soils and the assessment of risk resulting from contamination. Apart from an overview of the existing literature on biomarkers, the results of various of our field experiments in South African soils are discussed. Biomarkers may have potential in the assessment of risk because they can indicate at an early stage that exposure has taken place and that a toxic response has been initiated. It is therefore expected that early biomarkers will play an increasing role as diagnostic tools for determining exposure to chemicals and the resulting effects. They may have predictive value that can assist in the prevention or minimising of risks. The aim of this study was to investigate the possibilities of using our results on biomarker responses of soil dwelling organisms to predict changes at higher organisational levels (which may have ecological implications). Our recent experimental results on the evaluation of various biomarkers in both the laboratory and the field are interpreted and placed in perspective within the broader framework of response biology. The aim was further to contribute to the development and application of biomarkers in regulatory risk assessment schemes of soils. This critical review of our own and recent literature on biomarkers in ecotoxicology leads to the conclusion that biomarkers can, under certain conditions, be useful tools in risk assessment. Clear relationships between contamination loads in soil organisms and certain biomarker responses were determined in woodlice, earthworms and terrestrial snails. Clear correlations were also established in field experiments between biomarker responses and changes at the population level. This indicated that, in spite of the fact that direct mechanistic links are still not clarified, biomarkers may have the potential to provide early indications of forthcoming changes at higher organisational levels. Ways are proposed in which biomarkers could be used in the future in risk assessment schemes of soils and future research directions are suggested. 

Effect of fertiliser phosphorus and nitrogen on the concentrations of oil and protein in grain and the grain yield of canola (Brassica napus L.) grown in south-western Australia

2007 ◽  
Vol 47 (8) ◽  
pp. 984 ◽  
Author(s):  
R. F. Brennan ◽  
M. D. A. Bolland
Keyword(s):  
Brassica Napus ◽  
Grain Yield ◽  
Western Australia ◽  
Field Experiments ◽  
Grain Production ◽  
Brassica Napus L ◽  
Single Superphosphate ◽  
P Deficiency ◽  
Soil P ◽  
Soil P Testing

The effect of fertiliser phosphorus (P) and nitrogen (N) on seed (grain) yield and concentration of oil and protein in grain of canola (oil-seed rape; Brassica napus L.) was measured in two field experiments undertaken at eight sites from 1993–2005 in south-western Australia, on soils deficient in P and N. Six rates of P (0–40 kg P/ha as single superphosphate) and four rates of N (0–138 kg N/ha as urea) were applied. Significant grain yield increases (responses) to applied P occurred in both experiments and these responses increased as rates of applied N increased. For grain production, the P × N interaction was significant in all eight years and locations of the two experiments. Application of P had no effect on concentration of oil and protein in grain. Application of N always decreased the concentration of oil and increased the concentration of protein in grain. For canola grain production in the region, responses to applied N always occur whereas responses to applied P are rare, but if soil P testing indicates likely P deficiency, both P and N fertiliser need to be applied.

scholarly journals Updated Opinion of the Uterus Commission of the Gynecological Oncology Working Group (AGO) and the Gynecological Endoscopy Working Group (AGE) of the German Society of Gynecology and Obstetrics (DGGG) on the Randomized Study Comparing Minimally Invasive with Abdominal Radical Hysterectomy for Early-stage Cervical Cancer (LACC)

2019 ◽  
Vol 79 (02) ◽  
pp. 145-147 ◽  
Author(s):  
Peter Hillemanns ◽  
Sara Brucker ◽  
Bernd Holthaus ◽  
Rainer Kimmig ◽  
Björn Lampe ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Minimally Invasive ◽  
Radical Hysterectomy ◽  
Working Group ◽  
Early Stage ◽  
Randomized Study ◽  
Published Data ◽  
Gynecological Oncology ◽  
Gynecology And Obstetrics ◽  
Early Stage Cervical Cancer

AbstractIn this opinion on the randomized study comparing minimally invasive with abdominal radical hysterectomy for early-stage cervical cancer (LACC), the Uterus Commission of the Gynecological Oncology Working Group (AGO) and the Gynecological Endoscopy Working Group (AGE) of the Germany Society of Gynecology and Obstetrics (DGGG) state that, based on their examination of the published data, patients with FIGO stage IA1 (with LVSI), IA2 or IB1 cervical cancer must be informed about the results of this LACC study prior to making a decision on the route for radical hysterectomy.

scholarly journals Transcatheter Arterial Chemoembolization Based on Hepatic Hemodynamics for Hepatocellular Carcinoma

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Satoru Murata ◽  
Takahiko Mine ◽  
Tatsuo Ueda ◽  
Ken Nakazawa ◽  
Shiro Onozawa ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Conservative Therapy ◽  
Transcatheter Arterial Chemoembolization ◽  
Early Stage ◽  
Percutaneous Ablation ◽  
Published Data ◽  
Advanced Stage ◽  
Multikinase Inhibitor ◽  
The World ◽  
Arterial Chemoembolization

Hepatocellular carcinoma (HCC) is the sixth most common cancer and the third leading cause of cancer-related deaths in the world. The Barcelona Clinic Liver Cancer (BCLC) classification has recently emerged as the standard classification system for clinical management of patients with HCC. According to the BCLC staging system, curative therapies (resection, transplantation, and percutaneous ablation) can improve survival in HCC patients diagnosed at an early stage and offer potential long-term curative effects. Patients with intermediate-stage HCC benefit from transcatheter arterial chemoembolization (TACE), and those diagnosed at an advanced stage receive sorafenib, a multikinase inhibitor, or conservative therapy. Most patients receive palliative or conservative therapy only, and approximately 50% of patients with HCC are candidates for systemic therapy. TACE is often recommended for advanced-stage HCC patients all over the world because these patients desire therapy that is more effective than systemic chemotherapy or conservative treatment. This paper aims to summarize both the published data and important ongoing studies for TACE and to discuss technical improvements in TACE for advanced-stage HCC.

Mineral assemblages and xenolith cargo in the Storkwitz carbonatite (Delitzsch Complex, Germany)

2020 ◽  
Author(s):  
Hripsime Gevorgyan ◽  
Sascha Schmidt ◽  
Ilja Kogan ◽  
Manuel Lapp
Keyword(s):  
Late Cretaceous ◽  
Early Stage ◽  
Soft Rock ◽  
Core Material ◽  
Compositional Variation ◽  
Published Data ◽  
Fine Grained ◽  
Ultramafic Lamprophyre ◽  
The Matrix ◽  
History Of

<p>The multi-compositional carbonatite body of Storkwitz is one of several purported diatremes of the Late Cretaceous Delitzsch Complex, which comprises carbonatites and ultramafic lamprophyres emplaced into a heterogeneous series of volcanic and sedimentary rocks of Precambrian to Early Permian age (Krüger et al., 2013; Seifert et al., 2000). The Late Cretaceous peneplain is covered with about one hundred meters of Tertiary soft rock. According to Röllig et al. (1990), the Delitzsch Complex developed in six stages: (i) hidden intrusion of a dolomite carbonatite (rauhaugite) that led to the formation of a fenite aureole; (ii) ultramafic and alkaline lamprophyre intrusion (alnöite, aillikite, monchiquite); (iii) formation of beforsitic diatremes (intrusive breccias), including xenoliths of dolomite carbonatite and ultramafic lamprophyre; (iv) ultramafic and alkali lamprophyres (dykes within diatremes of 3<sup>rd</sup> stage); (v) formation of beforsite and (vi) alvikite dykes.</p><p>The Storkwitz carbonatite is mainly characterized by beforsitic breccias containing abundant angular xenoliths of metasediments form the complete underlying stratigraphic succession, metamorphic and igneous rocks, as well as rounded xenoliths of ultramafic lamprophyre, rauhaugite, fenite, and glimmerite, which suggest the existence of a deep-seated carbonatite pluton (Seifert et al., 2000). It is remarkable that the fenites exhibit a different degree of fenitization and show occurrence of phlogopite in the strongly fenitized samples. The matrix of the Storkwitz carbonatite is mainly composed of ankerite and calcite/siderite, which corresponds to ferro- or silico-carbonatites.</p><p>Detailed petrographical observations on extensive drill core material, new analyses and a reinterpretation of published data confirm the existence of compositional variation and zonation within the carbonatite body that reflect independent crystallization history and formation due to multiple magmatic events. The different generations of apatite and phlogopite from the early stage of the plutonic dolomite carbonatite through the late-stage beforsite dykes and fine-grained calcite carbonatite veins shed light on the crystallization history and magma development of carbonatites.</p><p> </p><p>References</p><p> </p><p>Krüger, J.C., Romer, R.L., Kämpf, H., 2013. Late Cretaceous ultramafic lamprophyres and carbonatites from the Delitzsch Complex, Germany. Chemical Geology, 353, 140-150.</p><p>Röllig, G., Viehweg, M., Reuter, N., 1990. The ultramafic lamprophyres and carbonatites of Delitzsch/GDR. Zeitschrift für Angewandte Geologie, 36, 49-54.</p><p>Seifert, W., Kämpf, H., Wasternack, J., 2000. Compositional variation in apatite, phlogopite and other accessory minerals of the ultramafic Delitzsch complex, Germany: implication for cooling history of carbonatites. Lithos, 53, 81-100.</p>

The Outcome of CLL Patients with 97% Identity to Germline Is Inferior to Other ‘Mutated’ Cases Defined by a 98% Cut off

Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. 2842-2842
Author(s):  
Zadie Davis ◽  
Anton Parker ◽  
Daniel Catovsky ◽  
David Oscier
Keyword(s):  
Cox Regression ◽  
Conflicts Of Interest ◽  
Early Stage ◽  
Prognostic Significance ◽  
Published Data ◽  
Early Stage Disease ◽  
Ighv Gene ◽  
Significant Difference ◽  
Gene Usage ◽  
The Uk

Abstract Abstract 2842 IGHV gene mutational load and use of specific IGHV genes and stereotypes have all been reported to have prognostic significance in CLL. In the UK CLL4 trial there were significant differences in response rate and progression free survival regardless of whether a 97% or 98% cut off was used, and the percentage of mutations which correlates best with clinical outcome remains controversial. We performed IGHV gene sequencing on 1071 patients with CLL or ‘clinical’ MBL (n= 153) in whom biomarkers, time to first treatment (TTFT) and overall survival (OS) were available. Four hundred and ninety six cases were entered into the UK CLL4 trial and 575 presented or were referred to the Royal Bournemouth Hospital. TTFT and OS were determined for cases with <96% identity and for each mutational point from 96% – 100% identity separately, excluding cases utilising IGHV3-21 assigned to stereotype subset 2. There was a significant difference in median TTFT and median OS between those with 97% identity (TTFT-20.9 and OS-99.3 months) and <97% identity (TTFT-118 and OS-191 months; p<0.001 and p<0.001), but not between cases with 97% and >97% identity (TTFT -13.1 months p=0.052 and OS-84.5 months p=0.177). When TTFT was determined for patients with early stage disease only (stage A CLL or CLL-like MBL, n=571), those with 97% identity, determined using either leader sequence or BIOMED 2 primers, had a significantly longer median TTFT than those with >97% identity (92.0 and 36.4 months respectively; p=0.012) and significantly shorter than those cases with <97% identity (273.1 months; p=0.012). If only stage A cases were analysed, those with 97% identity had a significantly longer median TTFT than those with >97% identity (TTFT; 68 vs. 26 months p=0.034). However, when compared to cases with <97% identity, there was a trend towards a shorter TTFT but significance was not reached (68 vs. 128 months p=0.060). A series of Cox Regression analyses were conducted to see if the prognostic value of the 98% cut off in MBL/stage A cases could be improved. In univariate analyses a model which incorporated <97%, 97%, >97% identity and stereotype subset 2 was the best discriminator of TTFT (p=0.0011) (Figure 1).Figure 1.Four subgroups of MBL/stage A CLL with differing TTFT based on stereotype subset 2 and relationship to 97% germline identityFigure 1. Four subgroups of MBL/stage A CLL with differing TTFT based on stereotype subset 2 and relationship to 97% germline identity Multivariate analysis, selected 97% and >97% identity as independent predictors of shorter TTFT (HR 2.5; 95% CI 1.3–4.9; p=0.007 and HR 4.2; 95% CI 2.9–6.1; p<0.001 respectively) in a model including <97%, 97%, >97% identity to germline, age at diagnosis, gender, expression of ZAP70, expression of CD38, del11q, del17p, stereotypy and stereotype subset 2 (Table 1). Further analyses were performed to investigate whether the differences in TTFT between cases with <97%, 97% or >97% identity could be explained by differences in IGHV gene usage. Sixty-one percent of cases with 97% identity to germline utilised only five genes; IGHV3-21, IGHV3-23, IGHV3-48, IGHV3-53 and IGHV1-18 and these genes were significantly over-represented in cases with 97% compared to either, cases with <97% (p>0.001) or >97% (p>0.001). When subset 2 cases were excluded, there was no difference in TTFT between cases using the above 5 genes and all other IGHV genes at this identity (p=0.288). In contrast to previously published data we found no difference in TTFT between mutated IGHV3-23 cases and other mutated cases (using a 98% cut-off), but IGHV3-23 cases with 97% identity had a shorter TTFT than cases with <97% identity (p<0.001). In conclusion the clinical course of cases with 97% identity, especially if diagnosed early in their disease, appears distinct from other cases defined as having mutated IGHV genes using the conventional 98% cut off. This is not accounted for by differences in IGHV gene usage, the incidence of stereotypy or other biomarkers and may reflect differences in response to BCR stimulation between cases with 97% and <97% identity.Table.Multivariate analysis for TTFT in MBL/stage A CLLOutcomeCovariateHazard Ratio (HR)95% CI for HRSignificance (p)TTFT97% identity2.51.3–4.90.007>97% identity4.22.9–6.1<0.001Subset 23.71.8–7.4<0.001Del11q1.71.1–2.70.014CD381.51.0–2.00.028Age at diagnosis0.980.96–0.99<0.001 Only covariates selected as significant are listed above. Disclosures: No relevant conflicts of interest to declare.

Radiation-induced lung and heart toxicity in patients with early-stage breast cancer treated with hypofractionated radiotherapy following breast-conservative surgery.

2013 ◽  
Vol 31 (26_suppl) ◽  
pp. 73-73 ◽  
Author(s):  
Ioanna Fragkandrea-Nixon
Keyword(s):  
Breast Cancer ◽  
Negative Impact ◽  
Early Stage ◽  
Strong Association ◽  
Univariate Analysis ◽  
Conservative Surgery ◽  
Published Data ◽  
Breast Radiotherapy ◽  
Whole Breast Radiotherapy ◽  
Group B

73 Background: Hypofractionated RT for breast cancer (BC), although reducing cost and time, could have negative impact on normal underlying lung and heart. We studied and compared lung function and the post –RT radiological changes using High–Resolution CT (HRCT) in early BC patients, treated with 3-D conformal whole breast radiotherapy (WBRT) using either conventional or hypofractionated regime. Additionaly, in patients with right-sided breast cancer, we monitored changes in LVEF performing MUGA scans. Methods: Between 2008 and 2009, 61 early BC patients (TI-2N0M0) were randomised into Group A (n=31) and Group B (n=30) receiving standard radiotherapy with 50Gy/25f/5w plus boost 10Gy/5f/1w to tumour bed or 43.2Gy/16f/22d plus same boost dose respectively. All patients were subjected to dynamic lung testing, on D0 (before RT), during and after RT at 3 and 6 months. HRCT scans were performed at baseline, and 3, 6, 12 months after RT. Dosimetric factors (CLD, V20, D25, MLD) were calculated. MUGA was performed in patients with right sided BC prior and 6 and 12 months post RT. Results: At 3 months after RT, pulmonary changes were classified at HRCT as follows: 91.8% were Grade 0, 8.19% Grade 1, and 0% Grade 2. At 6 months, 86.98% were Grade 0, 11.47 % Grade 1, and 1.6% Grade 2. At 12 months, 88.52% were Grade 0, 9.19 % Grade 1 and 3.27% Grade 2. Univariate analysis showed strong association between radiation pneumonitis, age and all dosimetric parameters. There was no association between fractionation type and incidence of RN. FEV1, FVC, FEV 25, FEV 50 and DLCO showed no statistically significant reduction in both treatment groups in 3 and 6 months following RT, compared to baseline. Multivariate analysis showed no relation between HRCT findings and age, smoking, chemotherapy, hormonotherapy, V20. No changes were found in LVEF prior and 6 and 12 months post radiotherapy. Conclusions: Lung toxicity as assessed with HRCT and PFTs was minimal in both treatment arms and our results are in consistency with other published data. In our series, no significant changes were found in LVEF in both treatment arms.

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