Biological basis for variation in residual feed intake in beef cattle. 2. Synthesis of results following divergent selection

2004 ◽  
Vol 44 (5) ◽  
pp. 431 ◽  
Author(s):  
E. C. Richardson ◽  
R. M. Herd
Keyword(s):  
Beef Cattle ◽  
Ion Transport ◽  
Feed Intake ◽  
Protein Turnover ◽  
Residual Feed Intake ◽  
Divergent Selection ◽  
Tissue Metabolism ◽  
Indirect Measures ◽  
Selection For ◽  
The Difference

Experiments on Angus steer progeny following a single generation of divergent selection for residual feed intake suggest that there are many physiological mechanisms contributing to variation in residual feed intake. Difference in energy retained in protein and fat accounted for only 5% of the difference in residual feed intake following divergent selection. Differences in digestion contributed (conservatively) 10% and feeding patterns 2% to the variation in residual feed intake. The heat increment of feeding contributed 9% and activity contributed 10%. Indirect measures of protein turnover suggest that protein turnover, tissue metabolism and stress contributed to at least 37% of the variation in residual feed intake. About 27% of the difference in residual feed intake was due to variation in other processes such as ion transport, not yet measured. It is hypothesised that susceptibility to stress is a key driver for many of the biological differences observed following divergent selection for residual feed intake in beef cattle. Further research is required to accurately quantify the effect of selection for improved residual feed intake on protein turnover, tissue metabolism and ion transport, and to confirm the association between stress susceptibility and residual feed intake in beef cattle.

230 Effect of divergent selection for residual feed intake on whole body protein turnover in growing gilts fed either adequate or lysine deficient diets

2016 ◽  
Vol 94 (suppl_2) ◽  
pp. 108-109 ◽  
Author(s):  
D. J. Hewitt ◽  
C. F. M. de Lange ◽  
T. Antonick ◽  
J. C. M. Dekkers ◽  
A. R. Pendleton ◽  
...  
Keyword(s):  
Feed Intake ◽  
Protein Turnover ◽  
Residual Feed Intake ◽  
Divergent Selection ◽  
Whole Body ◽  
Body Protein ◽  
Selection For

scholarly journals RAPID COMMUNICATION: Residual feed intake in beef cattle is associated with differences in protein turnover and nutrient transporters in ruminal epithelium

2019 ◽  
Vol 97 (5) ◽  
pp. 2181-2187
Author(s):  
Ahmed A Elolimy ◽  
Emad Abdel-Hamied ◽  
Liangyu Hu ◽  
Joshua C McCann ◽  
Daniel W Shike ◽  
...  
Keyword(s):  
Amino Acid ◽  
Beef Cattle ◽  
Protein Degradation ◽  
Insulin Signaling ◽  
Feed Intake ◽  
Feed Efficiency ◽  
Protein Turnover ◽  
Residual Feed Intake ◽  
Ubiquitin Proteasome ◽  
Ruminal Epithelium

Abstract Residual feed intake (RFI) is a widely used measure of feed efficiency in cattle. Although the precise biologic mechanisms associated with improved feed efficiency are not well-known, most-efficient steers (i.e., with low RFI coefficient) downregulate abundance of proteins controlling protein degradation in skeletal muscle. Whether cellular mechanisms controlling protein turnover in ruminal tissue differ by RFI classification is unknown. The aim was to investigate associations between RFI and signaling through the mechanistic target of rapamycin (MTOR) and ubiquitin-proteasome pathways in ruminal epithelium. One hundred and forty-nine Red Angus cattle were allocated to 3 contemporary groups according to sex and herd origin. Animals were offered a finishing diet for 70 d to calculate the RFI coefficient for each. Within each group, the 2 most-efficient (n = 6) and least-efficient animals (n = 6) were selected. Compared with least-efficient animals, the most-efficient animals consumed less feed (P < 0.05; 18.36 vs. 23.39 kg/d DMI). At day 70, plasma samples were collected for insulin concentration analysis. Ruminal epithelium was collected immediately after slaughter to determine abundance and phosphorylation status of 29 proteins associated with MTOR, ubiquitin-proteasome, insulin signaling, and glucose and amino acid transport. Among the proteins involved in cellular protein synthesis, most-efficient animals had lower (P ≤ 0.05) abundance of MTOR, p-MTOR, RPS6KB1, EIF2A, EEF2K, AKT1, and RPS6KB1, whereas MAPK3 tended (P = 0.07) to be lower. In contrast, abundance of p-EEF2K, p-EEF2K:EEF2K, and p-EIF2A:EIF2A in most-efficient animals was greater (P ≤ 0.05). Among proteins catalyzing steps required for protein degradation, the abundance of UBA1, NEDD4, and STUB1 was lower (P ≤ 0.05) and MDM2 tended (P = 0.06) to be lower in most-efficient cattle. Plasma insulin and ruminal epithelium insulin signaling proteins did not differ (P > 0.05) between RFI groups. However, abundance of the insulin-responsive glucose transporter SLC2A4 and the amino acid transporters SLC1A3 and SLC1A5 also was lower (P ≤ 0.05) in most-efficient cattle. Overall, the data indicate that differences in signaling mechanisms controlling protein turnover and nutrient transport in ruminal epithelium are components of feed efficiency in beef cattle.

scholarly journals Meat quality and the calpain system of feedlot steers following a single generation of divergent selection for residual feed intake

2001 ◽  
Vol 41 (7) ◽  
pp. 1013 ◽  
Author(s):  
M. B. McDonagh ◽  
R. M. Herd ◽  
E. C. Richardson ◽  
V. H. Oddy ◽  
J. A. Archer ◽  
...  
Keyword(s):  
Feed Intake ◽  
Shear Force ◽  
High Efficiency ◽  
Subcutaneous Fat ◽  
Residual Feed Intake ◽  
Divergent Selection ◽  
Muscle Area ◽  
Eye Muscle ◽  
Single Generation ◽  
Selection For

Residual feed intake (RFI) is calculated as the difference between an animal’s actual feed intake and its expected feed intake based on its size and growth over a specified test period. Following a single generation of divergent selection for postweaning RFI, Angus steers and Angus × Hereford, Angus×Poll Hereford and Angus × Shorthorn crossbred steers born in 1996 and 1997 were fed in a feedlot. Cohorts of steers were slaughtered at the same age and had attained similar (P&gt;0.05) final liveweights: 467 kg for steers selected for low RFI (high efficiency; HE, n = 91) and 459 kg for steers selected for high RFI (low efficiency; LE, n = 98). The HE and LE steers had similar (P>0.05) carcass weight (247 and 244 kg), dressing percentage (53.1 and 53.2&percnt;) and eye-muscle area (58.9 and 60.3 cm 2 ). The HE steers had slightly less subcutaneous fat over the rib than the LE steers (9.2 v. 10.1 mm, P&lt;0.05), and there was a trend towards less fat over the rump of HE steers (11.5 v. 12.1 mm, P = 0.10). For meat samples taken from the M. longissimus dorsi (LD) there were no differences (P>0.05) between the HE and LE steers in content of intramuscular fat (5.4 and 5.3% fresh weight), marbling scores, meat colour and fat colour. There were also no differences (P>0.05) between HE and LE steers in shear force and compression values for samples of LD aged for 1 day (4.6 and 4.6 kg shear force, 1.45 and 1.44 kg compression), or for 14 days (3.8 and 3.5 kg, 1.36 and 1.32 kg). Myofibril fragmentation index (MFI) measures the breakdown of these structural elements which occurs as an initial step in the process of protein degradation and meat tenderisation. MFI was lower (i.e. less fragmentation; P<0.05) in LD samples from HE steers than from LE steers, both in samples aged for 1 day (67.7 v. 72.5 units) and in samples aged for 14 days (87.8 v. 91.1 units). The rate of decline in MFI between 1 and 14 days post slaughter was similar in the LD samples from both lines of steers. There were no differences (P>0.05) between HE and LE steers in the activity of m-calpain and &micro;-calpain in LD immediately after slaughter (HE steers: 1.9 and 2.3 units, LE steers: 1.8 and 2.1 units). The level of calpastatin in LD from the HE steers was 13% higher than in the LD from the LE steers (5.2 and 4.6 units respectively, P<0.05). Rate of myofibril fragmentation was positively correlated (P<0.01) with the ratios of both m-calpain and µ-calpain to calpastatin, but not (P>0.10) with levels of either calpain or calpastatin. A single generation of divergent selection for RFI produced differences in calpastatin and myofibril fragmentation that may, with on-going selection for low RFI, negatively affect meat tenderness.

Residual feed intake-An emerging system for selection of efficient animals: A review

2016 ◽  
Vol 37 (1) ◽  
Author(s):  
Raju Kushwaha ◽  
A. K. Singh ◽  
M. Kumar
Keyword(s):  
Feed Intake ◽  
Growth Traits ◽  
Residual Feed Intake ◽  
Economic Benefits ◽  
Current State ◽  
Feeding Regimes ◽  
Selection For ◽  
The Difference ◽  
Economic Analyses ◽  
Available Information

Residual feed intake (RFI) is a measure of feed efficiency, and is defined as the difference between an animal’s actual feed intake and its expected feed intake based on its size and growth. It is independent of the level of production, and the lower the value the more efficient the animal is. This paper examines the current state of knowledge on RFI. Available information indicates that postweaning RFI is moderately heritable, and that selection for low RFI will result in progeny that consume less feed for the same level of production as progeny of high RFI cattle. Under ad libitum feeding, RFI is phenotypically independent of growth traits. There is a weak genetic relationship between RFI and fatness but additional studies are needed to assess the magnitude of this relationship in different breeds, sexes, ages and feeding regimes. Residual feed intake is believed to represent inherent variation in basic metabolic processes which determine efficiency. Economic analyses of genetic improvement schemes that incorporate testing of individuals for RFI have yielded substantial economic benefits over and above existing schemes that do not include RFI testing. Selection for low RFI has an additional benefit of reducing greenhouse gas emissions by cattle.

scholarly journals Review: divergent selection for residual feed intake in the growing pig

animal ◽  
2017 ◽  
Vol 11 (9) ◽  
pp. 1427-1439 ◽  
Author(s):  
H. Gilbert ◽  
Y. Billon ◽  
L. Brossard ◽  
J. Faure ◽  
P. Gatellier ◽  
...  
Keyword(s):  
Feed Intake ◽  
Residual Feed Intake ◽  
Divergent Selection ◽  
Growing Pig ◽  
Selection For

scholarly journals Effect of immune system stimulation and divergent selection for residual feed intake on digestive capacity of the small intestine in growing pigs1

2012 ◽  
Vol 90 (suppl_4) ◽  
pp. 233-235 ◽  
Author(s):  
A. Rakhshandeh ◽  
J. C. M. Dekkers ◽  
B. J. Kerr ◽  
T. E. Weber ◽  
J. English ◽  
...  
Keyword(s):  
Small Intestine ◽  
Immune System ◽  
Feed Intake ◽  
Residual Feed Intake ◽  
Divergent Selection ◽  
Digestive Capacity ◽  
Selection For
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