The Synthesis of a Fluorescent Cholesteryl Oleate Analogue

1996 ◽  
Vol 49 (11) ◽  
pp. 1243 ◽  
Author(s):  
WM Best ◽  
BC Mortimer ◽  
TG Redgrave ◽  
RV Stick
Keyword(s):  
Oleic Acid ◽  
Carboxylic Acid ◽  
Cholesteryl Oleate

A fluorescent analogue of cholesteryl oleate , namely 22-[ethyl(2'-naphthyl)amino]-23,24-dinorchol-5-en-3β-yl oleate, has been prepared from a steroidal carboxylic acid, 2-naphthylamine and oleic acid.

scholarly journals Performance of Oleic Acid and Soybean Oil in the Preparation of Oil-in-Water Microemulsions for Encapsulating a Highly Hydrophobic Molecule

2021 ◽  
Vol 5 (4) ◽  
pp. 50
Author(s):  
Laura Fernández-Peña ◽  
Boutaina Z. El Mojahid ◽  
Eduardo Guzmán ◽  
Francisco Ortega ◽  
Ramón G. Rubio
Keyword(s):  
Oleic Acid ◽  
Carboxylic Acid ◽  
Soybean Oil ◽  
Size Range ◽  
Pharmaceutical Formulations ◽  
Oil In Water ◽  
Hydrophobic Molecule ◽  
The Stability ◽  
Highly Hydrophobic ◽  
Nanometric Size

This work analyzes the dispersion of a highly hydrophobic molecule, (9Z)-N-(1,3-dihydroxyoctadecan-2-yl)octadec-9-enamide (ceramide-like molecule), with cosmetic and pharmaceutical interest, by exploiting oil-in-water microemulsions. Two different oils, oleic acid and soybean oil, were tested as an oil phase while mixtures of laureth-5-carboxylic acid (Akypo) and 2-propanol were used for the stabilization of the dispersions. This allowed us to obtain stable aqueous-based formulations with a relatively reduced content of oily phase (around 3% w/w), that may enhance the bioavailability of this molecule by its solubilization in nanometric oil droplets (with a size range of 30–80 nm), that allow the incorporation of a ceramide-like molecule of up to 3% w/w, to remain stable for more than a year. The nanometric size of the droplet containing the active ingredient and the stability of the formulations provide the basis for evaluating the efficiency of microemulsions in preparing formulations to enhance the distribution and availability of ceramide-like molecules, helping to reach targets in cosmetic and pharmaceutical formulations.

scholarly journals Oleic Acid-Based Gemini Surfactants with Carboxylic Acid Headgroups

2011 ◽  
Vol 60 (8) ◽  
pp. 411-417 ◽  
Author(s):  
Kenichi Sakai ◽  
Naoki Umemoto ◽  
Wataru Matsuda ◽  
Yuichiro Takamatsu ◽  
Mutsuyoshi Matsumoto ◽  
...  
Keyword(s):  
Oleic Acid ◽  
Carboxylic Acid ◽  
Gemini Surfactants

scholarly journals GC-MS ANALYSIS OF PHYTOCHEMICALS FROM THE EXTRACT OF Hibiscus sabdariffa GROWN IN NORTHERN NIGERIA

2021 ◽  
Vol 46 (2) ◽  
Author(s):  
G.J. Okore ◽  
E. E. Oguzie ◽  
C. E. Ogukwe ◽  
C. O. Akalezi
Keyword(s):  
Oleic Acid ◽  
Carboxylic Acid ◽  
Acid Methyl Ester ◽  
Ethanol Extract ◽  
Dienoic Acid ◽  
Hibiscus Sabdariffa ◽  
Ms Analysis ◽  
Pharmacological Potential ◽  
Cyclohexane Carboxylic Acid ◽  
Peak Value

Hibiscus sabdariffa, also known as Roselle belongs to Malvacae family. It is popularly known in Nigeria as Zobo. It has been used traditionally to cure certain ailments like cold, due to its rich pharmacological potential. Hence this study aimed at validating the pharmacological potential of Hibiscus sabdariffa by identification of the compounds present in its leaves using GC-MS technique. The extract was obtained by heating the leaves in ethanol under reflux. The ethanol extract was then subjected to GC-MS analysis. The constituents were identified by comparing their mass fragmentation (MS) pattern with those gathered in the library of NIST-MS and with those reported in literature. The graph obtained from the study revealed the presence of nine (9) organic compounds in Hibiscus sabdariffa leaf extract (HSLE) namely cyclohexane carboxylic acid ester, cyclopropane carboxylic acid methyl ester, hexanoic acid-4-octyl ester, hexadeca-2-11-dienoic acid, n-hexadecanoic acid, oleic acid, octadecanoic acid, E-13-docosenoic acid and E-11-hexadecanal. Oleic acid has the highest peak value with the retention time of 20.711 which makes it the most abundant fraction and the active ingredient in the HSLE. The presence of some of these bioactive compounds has proved the scientific evidences for the antihypertensive and anti-inflammatory properties of the plant.

scholarly journals Unravelling the Thermal Decomposition Parameters for the Synthesis of Anisotropic Iron Oxide Nanoparticles

2018 ◽  
Author(s):  
Geoffrey Cotin ◽  
Celine Kiefer ◽  
Francis Perton ◽  
Dris Ihiawakrim ◽  
Cristina Blanco-Andujar ◽  
...  
Keyword(s):  
Oleic Acid ◽  
Iron Oxide ◽  
Carboxylic Acid ◽  
Iron Oxide Nanoparticles ◽  
Sodium Oleate ◽  
Shape Control ◽  
Oxide Nanoparticles ◽  
Synthesis Methods ◽  
Surfactant Mixtures ◽  
Negative Effect

Iron oxide nanoparticles are widely used as contrast agent for MRI and may be used as therapeutic agent by magnetic hyperthermia if they display a high magnetic anisotropy. Considering the effect of the nanoparticles shape on anisotropy, the reproducible shape control of nanoparticles is currently a challenge of synthesis methods. By investigating reaction parameters which are the iron precursor structure, the water content and the amount of the surfactant, sodium oleate, reported to trigger the cubic shape, iron oxide nanoparticles with different shape and composition were observed to form. In particular, iron oxide nanoplates have been thus synthesized. The effect of the surfactant coming from precursor was taking into account by using in house iron stearates bearing either two or three stearate chains and the negative effect of water on shape was confirmed by considering these precursors after their dehydration. Nanocubes with straight faces and a FeO@Fe3-xO4 composition were obtained only with dehydrated precursors and 50% of sodium oleate in the oleic acid and sodium oleate surfactant mixtures. When iron stearates with three chains led mainly to nanocubes in presence of soduim oleate, Iron stearates with two chains led to the formation of nanoplates with 80% of sodium oleate. The original flat shape of the plates was confirmed with 3D TEM tomography. The investigation of the synthesis mechanisms confirmed the major role of deprotonated carboxylic acid and of the heating rate to drive the cubic shape of nanoparticles and showed that the nanoplate formation would depend mainly on the nucleation step and possibly on the presence of a given ratio of oleic acid and deprotonated carboxylic acid.

A magnetic super lattice

1987 ◽  
Vol 45 ◽  
pp. 360-361 ◽  
Author(s):  
M.D. Bentzon ◽  
J. v. Wonterghem ◽  
A. Thölén
Keyword(s):  
Thermal Decomposition ◽  
Oleic Acid ◽  
Magnetic Fluid ◽  
Magnetic Particles ◽  
Carbon Film ◽  
Thick Layer ◽  
Amorphous Iron ◽  
Super Lattice ◽  
Carrier Liquid ◽  
Median Diameter

We report on the oxidation of a magnetic fluid. The oxidation results in magnetic super lattice crystals. The “atoms” are hematite (α-Fe2O3) particles with a diameter ø = 6.9 nm and they are covered with a 1-2 nm thick layer of surfactant molecules.Magnetic fluids are homogeneous suspensions of small magnetic particles in a carrier liquid. To prevent agglomeration, the particles are coated with surfactant molecules. The magnetic fluid studied in this work was produced by thermal decomposition of Fe(CO)5 in Declin (carrier liquid) in the presence of oleic acid (surfactant). The magnetic particles consist of an amorphous iron-carbon alloy. For TEM investigation a droplet of the fluid was added to benzine and a carbon film on a copper net was immersed. When exposed to air the sample starts burning. The oxidation and electron irradiation transform the magnetic particles into hematite (α-Fe2O3) particles with a median diameter ø = 6.9 nm.

Intestinal Absorption of Iodine131-Labeled Triolein and Oleic Acid in Normal Subjects and in Steatorrhea

1958 ◽  
Vol 34 (5) ◽  
pp. 901-909 ◽  
Author(s):  
Ervin Kaplan ◽  
Bernard D. Edidin ◽  
Robert C. Fruin ◽  
Lyle A. Baker
Keyword(s):  
Oleic Acid ◽  
Intestinal Absorption ◽  
Normal Subjects

Fibrinolytic Activity of Cerebro-Spinal Fluid and the Development of Artificial Cerebral Haematomas in Dogs

1969 ◽  
Vol 21 (02) ◽  
pp. 294-303 ◽  
Author(s):  
H Mihara ◽  
T Fujii ◽  
S Okamoto
Keyword(s):  
Cerebrospinal Fluid ◽  
Carboxylic Acid ◽  
Fibrinolytic Activity ◽  
Clinical Implications ◽  
Trans Form ◽  
Plate Method ◽  
Blood Samples ◽  
Fibrin Plate ◽  
The Brain

SummaryBlood was injected into the brains of dogs to produce artificial haematomas, and paraffin injected to produce intracerebral paraffin masses. Cerebrospinal fluid (CSF) and peripheral blood samples were withdrawn at regular intervals and their fibrinolytic activities estimated by the fibrin plate method. Trans-form aminomethylcyclohexane-carboxylic acid (t-AMCHA) was administered to some individuals. Genera] relationships were found between changes in CSF fibrinolytic activity, area of tissue damage and survival time. t-AMCHA was clearly beneficial to those animals given a programme of administration. Tissue activator was extracted from the brain tissue after death or sacrifice for haematoma examination. The possible role of tissue activator in relation to haematoma development, and clinical implications of the results, are discussed.

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