Derivatives of 4-(Aminomethyl)pyrrole-3-carboxylic Acid

1994 ◽  
Vol 47 (5) ◽  
pp. 975 ◽  
Author(s):  
DP Arnold ◽  
RFC Brown ◽  
LJ Nitschinsk ◽  
P Perlmutter ◽  
HK Tope
Keyword(s):  
Carboxylic Acid ◽  
Ethyl Esters ◽  
Tosylmethyl Isocyanide ◽  
Derivatives Of

Methyl and ethyl esters of 4-( aminomethyl )pyrrole-3-carboxylic acid were made through pyrrole synthesis with tosylmethyl isocyanide , but cyclization to a bicyclic lactam (1) was not achieved.

1-Substitution derivatives of 4-aryl-2,3-dibromo-1-naphthol

1981 ◽  
Vol 46 (9) ◽  
pp. 2116-2122 ◽  
Author(s):  
Jiří Křepelka ◽  
Jiří Roubík ◽  
Jiří Holubek
Keyword(s):  
Aqueous Medium ◽  
Ethyl Esters ◽  
Derivatives Of

Alkylation of 7-ethyl-4-(4-ethylphenyl)-2,3-dibromo-1-naphthol (I) with ethyl esters of ω-bromoalkanoic acids XX-XXIII in a non-aqueous medium gave the 1-substitution derivatives II, IV, VI and VIII which were hydrolyzed to the acids III, V, VII and IX. The acid III was used for syntheses of the esters X-XIII and amides XIV-XVIII. Compounds II-XVIII exhibited moderate antineoplastic effects in animals with transplanted tumours; best results were observed with the compound II.

scholarly journals Novel Derivatives of 4-Methyl-1,2,3-Thiadiazole-5-Carboxylic Acid Hydrazide: Synthesis, Lipophilicity, and In Vitro Antimicrobial Activity Screening

2021 ◽  
Vol 11 (3) ◽  
pp. 1180
Author(s):  
Kinga Paruch ◽  
Łukasz Popiołek ◽  
Anna Biernasiuk ◽  
Anna Berecka-Rycerz ◽  
Anna Malm ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Carboxylic Acid ◽  
Bacterial Infections ◽  
Acid Hydrazide ◽  
Antimicrobial Effect ◽  
In Vitro Antimicrobial Activity ◽  
Research Goal ◽  
New Compounds ◽  
Derivatives Of

Bacterial infections, especially those caused by strains resistant to commonly used antibiotics and chemotherapeutics, are still a current threat to public health. Therefore, the search for new molecules with potential antimicrobial activity is an important research goal. In this article, we present the synthesis and evaluation of the in vitro antimicrobial activity of a series of 15 new derivatives of 4-methyl-1,2,3-thiadiazole-5-carboxylic acid. The potential antimicrobial effect of the new compounds was observed mainly against Gram-positive bacteria. Compound 15, with the 5-nitro-2-furoyl moiety, showed the highest bioactivity: minimum inhibitory concentration (MIC) = 1.95–15.62 µg/mL and minimum bactericidal concentration (MBC)/MIC = 1–4 µg/mL.

On the synthesis of 1,n -diketones using mono-substituted derivatives of tosylmethyl isocyanide

1985 ◽  
Vol 104 (2) ◽  
pp. 50-53 ◽  
Author(s):  
Albert M. van Leusen ◽  
Roelof Oosterwijk ◽  
Erik van Echten ◽  
Daan van Leusen
Keyword(s):  
Tosylmethyl Isocyanide ◽  
Derivatives Of

scholarly journals 3-Propionyl-thiazolidine-4-carboxylic acid ethyl esters: a family of antiproliferative thiazolidines

MedChemComm ◽  
2015 ◽  
Vol 6 (1) ◽  
pp. 90-93 ◽  
Author(s):  
F. Esra Önen-Bayram ◽  
Kerem Buran ◽  
Irem Durmaz ◽  
Barkin Berk ◽  
Rengul Cetin-Atalay
Keyword(s):  
Carboxylic Acid ◽  
Physicochemical Properties ◽  
Ethyl Esters

Modification at the 2-position of the apoptosis-inducing compound ALC 67 enables tuning of its physicochemical properties.

Some Basic Derivatives of 3-Methylflavone-8-carboxylic Acid

1960 ◽  
Vol 2 (3) ◽  
pp. 263-269 ◽  
Author(s):  
Paolo Da Re ◽  
Lucia Verlicchi ◽  
Ivo Setnikar
Keyword(s):  
Carboxylic Acid ◽  
Derivatives Of

scholarly journals Hyperbranched Molecular Structures with Potential Antiviral Activity: Derivatives of 5,6-Dihydroxyindole-2-Carboxylic Acid

Molecules ◽  
2006 ◽  
Vol 11 (12) ◽  
pp. 968-977 ◽  
Author(s):  
Mario Sechi ◽  
Fabio Casu ◽  
Ilaria Campesi ◽  
Stefano Fiori ◽  
Alberto Mariani
Keyword(s):  
Carboxylic Acid ◽  
Antiviral Activity ◽  
Molecular Structures ◽  
Derivatives Of

Heterocycles from 2-Aminopyridine and Derivatives of 3-Methylbenzofuran-2-carboxylic Acid

Heterocycles ◽  
1997 ◽  
Vol 45 (4) ◽  
pp. 787 ◽  
Author(s):  
Yvette A. Jackson ◽  
Mark F. Williams
Keyword(s):  
Carboxylic Acid ◽  
Derivatives Of

Aminoalkyl derivatives of 2,4′-bithiazole-4-carboxylic acid, the intercalating part of bleomycin

1984 ◽  
Vol 21 (3) ◽  
pp. 681-683 ◽  
Author(s):  
Raymond Houssin ◽  
Jean-Luc Bernier ◽  
Jean-Pierre Hénichart
Keyword(s):  
Carboxylic Acid ◽  
Derivatives Of
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