Tropical Marine Algae. IX. A New Sesquiterpenoid Metabolite From the Red Alga Laurencia marianensis

1993 ◽  
Vol 46 (6) ◽  
pp. 933 ◽  
Author(s):  
R Denys ◽  
JC Coll ◽  
BF Bowden
Keyword(s):  
Natural Products ◽  
Marine Algae ◽  
Red Alga ◽  
Natural Products Chemistry ◽  
First Time

An investigation of the natural products chemistry of the red alga Laurencia marianensis Yamada, a species whose chemistry has not previously been described in the literature, yielded the new metabolite 1-[(3′S*,3a′lR*,4′R*,7′S*,7a′S*)-7′-bromo-7a′-methyl-3′-(1′-methylethyl)octahydro-1′H-inden-4′-yl] ethanone (1) and the known metabolites deoxyprepacifenol (2) and pacifenol (3). The full n.m.r. characterization of (2) and (3) is reported for the first time.

Tropical Marine Algae. VIII. The Structural Determination of Novel Sesquiterpenoid Metabolites From the Red Alga .Laurencia majuscula

1992 ◽  
Vol 45 (10) ◽  
pp. 1611 ◽  
Author(s):  
R Denys ◽  
JC Coll ◽  
BF Bowden
Keyword(s):  
Natural Products ◽  
Great Barrier Reef ◽  
Marine Algae ◽  
Structural Type ◽  
Red Alga ◽  
Structural Determination ◽  
Barrier Reef ◽  
Natural Products Chemistry ◽  
Laurencia Majuscula

An investigation of the natural products chemistry of the red alga Laurencia mujuscula from the Great Barrier Reef yielded three novel metabolites, (1), (2) and (3a), possessing a new sesquiterpenoid structural type. Known metabolites (6)-(11) were also isolated and the reassignment of n.m.r. spectral values for (11) is reported.

scholarly journals Marine algae of St. Martin's Island, Bangladesh. XII. New records of red and green algae

1970 ◽  
Vol 40 (1) ◽  
pp. 41-45
Author(s):  
Abdul Aziz ◽  
Md Towhidur Rahman
Keyword(s):  
Key Words ◽  
Green Algae ◽  
Marine Algae ◽  
New Records ◽  
Red Alga ◽  
First Time

Ceramium tenerrimum (G. Martens) Okamura fa, Caulerpa sertularioides fa corymbosa Taylor and Cladophora vagabunda (L.) Hoek from St. Martin’s Island, Bangladesh have been recorded, and described and illustrated for the first time with descriptions and illustrations. Key words: Ceramium; Caulerpa; Cladophora; Red alga; Green algae; Bangladesh DOI: http://dx.doi.org/10.3329/bjb.v40i1.7996 Bangladesh J. Bot. 40(1): 41-45, 2011 (June)

Syntheses of Cytosporones A, C, J, K, and N, Metabolites from Medicinal Fungi

2015 ◽  
Vol 68 (10) ◽  
pp. 1583 ◽  
Author(s):  
Andrew M. Beekman ◽  
Russell A. Barrow
Keyword(s):  
Natural Products ◽  
Selective Reduction ◽  
Complete Characterization ◽  
Phenyl Acetate ◽  
Human Pathogens ◽  
Medicinal Fungi ◽  
C And N ◽  
Key Steps ◽  
First Time

The syntheses of the fungal metabolites cytosporones A, (±)-C, and N are reported. And the syntheses of cytosporones J and K are described for the first time. The preparation of racemic cytosporone J and racemic cytosporone K, natural products containing the rare 3-isochromanone substructure, was achieved in 8 linear steps with an overall yield of 45 % and 7 linear steps in 46 % yield, respectively, resulting in the complete characterization of these compounds for the first time. The key steps included a recently described homologation of benzoic acid to the analogous phenyl acetate using Birch reductive alkylation conditions, acylation of the appropriate phenyl acetate derivative, and a selective reduction and spontaneous biomimetic lactonization to yield the 3-isochromanone skeleton. The synthesized natural products were evaluated for their biological activity against several clinical strains of human pathogens with all compounds displaying weak antimicrobial activity.

Delisea pulchra (cf. fimbriata) Revisited. The Structural Determination of Two New Metabolites From the Red Alga Delisea pulchra

1992 ◽  
Vol 45 (10) ◽  
pp. 1625 ◽  
Author(s):  
R Denys ◽  
JC Coll ◽  
BF Bowden
Keyword(s):  
Red Alga ◽  
Structural Determination ◽  
Delisea Pulchra ◽  
First Time ◽  
New Metabolites

Two new metabolites (1a) and (2a) have been isolated from the red alga Delisea pulchra . The previously reported metabolites (3)-(7) were also isolated, and the full n.m.r. characterization of (3), (4) and (6) is reported for the first time.

Identification of some L-numbered Lycopodium alkaloids

1990 ◽  
Vol 68 (8) ◽  
pp. 1300-1304 ◽  
Author(s):  
William A. Ayer ◽  
Lois M. Browne ◽  
A. Warren Elgersma ◽  
Peter P. Singer
Keyword(s):  
Natural Products ◽  
Lycopodium Alkaloids ◽  
Complete Listing ◽  
First Time

The pioneering research on Lycopodium alkaloids carried out by R. H. F. Manske and L. Marion led to the characterization of a large number of alkaloids. Many of these alkaloids were designated by numbers preceded by an L (e.g., L1, which has since been shown to be dihydrolycopodine). While the identity of many of these alkaloids has now been established, several remain unreported. We have examined samples of alkaloids L15, L16, L17, L18, L22, L24, L25, L26, L28, L29, L31, and L35, obtained from Marion's collection, by GC–MS and GC–IR, and report herein the identity of these alkaloids and alkaloid mixtures. Most of the samples proved to be mixtures of known alkaloids. Acetylannofoline (5), a component of alkaloid L17, and 5,15-oxidolycopodane (9), a component of alkaloids L28 and L31, are identified for the first time as natural products. A complete listing of the L-numbered alkaloids is provided. Keywords: Lycopodium alkaloids, alkaloids, acetylannofoline, oxidolycopodane.

scholarly journals Characterization of Plasmodium falciparum Pantothenate Kinase and Identification of Its Inhibitors From Natural Products

2021 ◽  
Vol 11 ◽  
Author(s):  
Arif Nurkanto ◽  
Ghulam Jeelani ◽  
Herbert J. Santos ◽  
Yulia Rahmawati ◽  
Mihoko Mori ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Natural Products ◽  
Biosynthetic Pathway ◽  
Essential Role ◽  
Screening System ◽  
Metabolic Reactions ◽  
First Time ◽  
Rate Limiting ◽  
Primary Substrate

Coenzyme A (CoA) is a well-known cofactor that plays an essential role in many metabolic reactions in all organisms. In Plasmodium falciparum, the most deadly among Plasmodium species that cause malaria, CoA and its biosynthetic pathway have been proven to be indispensable. The first and rate-limiting reaction in the CoA biosynthetic pathway is catalyzed by two putative pantothenate kinases (PfPanK1 and 2) in this parasite. Here we produced, purified, and biochemically characterized recombinant PfPanK1 for the first time. PfPanK1 showed activity using pantetheine besides pantothenate, as the primary substrate, indicating that CoA biosynthesis in the blood stage of P. falciparum can bypass pantothenate. We further developed a robust and reliable screening system to identify inhibitors using recombinant PfPanK1 and identified four PfPanK inhibitors from natural compounds.

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