Reaction of 2-(6-Hydroxyspiro[4.5]Dec-6-Yl)-Alkanoic Acids With Aldehydes

1986 ◽  
Vol 39 (5) ◽  
pp. 799 ◽  
Author(s):  
T Fujita ◽  
S Watanabe ◽  
T Sotoguchi ◽  
K Ogawa ◽  
K Sugahara

The acid- catalysed reaction of aldehydes or ethyl vinyl ether with β- hydroxy acids containing a spiro ring is described. For example, 7,9- dioxadispiro [4.0.5.4]pentadecan-10-one was obtained in 90% yield from the reaction of (6-hydroxyspiro[4.5]dec-6-yl)acetic acid and 1,3,5- trioxan and 8-methyl-7,9-dioxadispiro[4.0.5.4]pentadecan-10-one was obtained in 72% yield from (6-hydroxyspiro[4.5]dec-6-yl)acetic acid and ethyl vinyl ether.

Synthesis ◽  
1979 ◽  
Vol 1979 (11) ◽  
pp. 910-911 ◽  
Author(s):  
Tsutomu Fujita ◽  
Shoji Watanabe ◽  
Kyoichi Suga ◽  
Toshio Isobe ◽  
Toshiro Miura

1955 ◽  
Vol 34 (4) ◽  
pp. 235???240 ◽  
Author(s):  
Max S. Sadove ◽  
Gordon M. Wyant ◽  
John O. Cletcher

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