Nucleophilic-Substitution Reactions in Benzo[C][1,8]Naphthyridines

1986 ◽  
Vol 39 (4) ◽  
pp. 667 ◽  
Author(s):  
LW Deady ◽  
DM Werden
Keyword(s):  
Nucleophilic Substitution ◽  
Relative Reactivity ◽  
Substitution Reactions ◽  
Reaction Conditions ◽  
Nucleophilic Substitution Reactions

The reactions of 1-chloro-3-methyl-6-(p- methylphenoxy ) benzo [c][1,8] naphthyridine with a variety of nucleophiles are reported. The relative reactivity of the 1- and 6-positions depends on the nucleophile and reaction conditions. Anilines, and alkyl and aryl thioxides react at position 1, alkylamines and alkoxide at position 6, and acidified alcohol at both 1 and 6. Some possible reasons for these positional reactivities are discussed.

scholarly journals N-Halosuccinimides as Precatalysts for C-, N-, O-, and X-Nucleophilic Substitution Reactions of Alcohols under Mild Reaction Conditions

Catalysts ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 460
Author(s):  
Njomza Ajvazi ◽  
Stojan Stavber
Keyword(s):  
Nucleophilic Substitution ◽  
Substrate Concentration ◽  
Solvent Free ◽  
Substitution Reactions ◽  
High Substrate Concentration ◽  
Reaction Conditions ◽  
High Substrate ◽  
Nucleophilic Substitution Reactions ◽  
Solvent Free Reaction

N-halosuccinimides (chloro, bromo, and iodo, respectively) were introduced, tested, and applied as efficient and non-metal precatalysts for C-, N-, O-, and X-nucleophilic substitution reactions of alcohols under solvent-free reaction conditions (SFRC) or under high substrate concentration reaction conditions (HCRC) efficiently and selectively, into the corresponding products.

A 2-methylthio-3,5-diaryl-1,3,4-thiadiazolium cation; its reactions, and further exploration of the chemistry of 2-alkyl-3,5-diaryl-1,3,4-thiadiazolium cations

1987 ◽  
Vol 65 (12) ◽  
pp. 2713-2716 ◽  
Author(s):  
Harold Mastalerz ◽  
Taj Mohammad ◽  
Martin S. Gibson
Keyword(s):  
Nucleophilic Substitution ◽  
Ethyl Acetoacetate ◽  
Diethyl Malonate ◽  
Ring System ◽  
Cationic Dyes ◽  
Substitution Reactions ◽  
Reaction Conditions ◽  
Nucleophilic Substitution Reactions ◽  
Thiadiazole Ring

Activation of a representative 3,5-diaryl-1,3,4-thiadiazole-2-thione by thione S-methylation gives a cation that is readily susceptible to nucleophilic substitution. Reactions with diethyl malonate, ethyl acetoacetate, acetylacetone, cyclopentan-1,3-dione, or 3-ethylrhodanine under basic conditions lead to β,β-disubstituted methine bases and (or) β-substituted methine bases in cases where deacetylation occurs under the reaction conditions. This cation and the 2-alkyl-3,5-diaryl-1,3,4-thiadiazolium cation are convenient sources of a series of neutral and cationic dyes containing the 1,3,4-thiadiazole ring system.

The unexpected reactivity of 9-iodo-nido-carborane: from nucleophilic substitution reactions to the synthesis of tricobalt tris(dicarbollide) Na[4,4′,4′′-(MeOCH2CH2O)3-3,3′,3′′-Co3(μ3-O)(μ3-S)(1,2-C2B9H10)3]

2021 ◽  
Vol 50 (7) ◽  
pp. 2671-2688
Author(s):  
Marina Yu. Stogniy ◽  
Sergey A. Anufriev ◽  
Akim V. Shmal'ko ◽  
Sergey M. Antropov ◽  
Aleksei A. Anisimov ◽  
...  
Keyword(s):  
Nucleophilic Substitution ◽  
Substitution Reactions ◽  
Nucleophilic Substitution Reactions

An unusual reactivity of 9-iodo-nido-carborane [9-I-7,8-C2B9H11]− towards nucleophiles under strong basic conditions was revealed.

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