Synthesis of Some Polybrominated Diphenyl Ethers Found in Marine Sponges

1985 ◽  
Vol 38 (8) ◽  
pp. 1271 ◽  
Author(s):  
KA Francesconi ◽  
EL Ghisalberti
Keyword(s):  
Polybrominated Diphenyl Ethers ◽  
Marine Sponges ◽  
Diphenyl Ethers

A simple general route for the synthesis of polybrominated diphenyl ethers is reported.

scholarly journals 40 Years of Research on Polybrominated Diphenyl Ethers (PBDEs)—A Historical Overview and Newest Data of a Promising Anticancer Drug

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 995
Author(s):  
Laura Schmitt ◽  
Ilka Hinxlage ◽  
Pablo A. Cea ◽  
Holger Gohlke ◽  
Sebastian Wesselborg
Keyword(s):  
Polybrominated Diphenyl Ethers ◽  
Mitochondrial Pathway ◽  
Marine Sponges ◽  
Jurkat Cells ◽  
Therapeutic Window ◽  
Relationship Analysis ◽  
Mechanistic Pathway ◽  
Chemistry Research ◽  
Diphenyl Ethers ◽  
Marine Compound

Polybrominated diphenyl ethers (PBDEs) are a group of molecules with an ambiguous background in literature. PBDEs were first isolated from marine sponges of Dysidea species in 1981 and have been under continuous research to the present day. This article summarizes the two research aspects, (i) the marine compound chemistry research dealing with naturally produced PBDEs and (ii) the environmental toxicology research dealing with synthetically-produced brominated flame-retardant PBDEs. The different bioactivity patterns are set in relation to the structural similarities and dissimilarities between both groups. In addition, this article gives a first structure–activity relationship analysis comparing both groups of PBDEs. Moreover, we provide novel data of a promising anticancer therapeutic PBDE (i.e., 4,5,6-tribromo-2-(2′,4′-dibromophenoxy)phenol; termed P01F08). It has been known since 1995 that P01F08 exhibits anticancer activity, but the detailed mechanism remains poorly understood. Only recently, Mayer and colleagues identified a therapeutic window for P01F08, specifically targeting primary malignant cells in a low µM range. To elucidate the mechanistic pathway of cell death induction, we verified and compared its cytotoxicity and apoptosis induction capacity in Ramos and Jurkat lymphoma cells. Moreover, using Jurkat cells overexpressing antiapoptotic Bcl-2, we were able to show that P01F08 induces apoptosis mainly through the intrinsic mitochondrial pathway.

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