Synthesis of the radical scavenger 1,1,3,3-Tetramethylisoindolin-2-yloxyl

1983 ◽  
Vol 36 (2) ◽  
pp. 397 ◽  
Author(s):  
PG Griffiths ◽  
G Moad ◽  
E Rizzardo
Keyword(s):  
Free Radical ◽  
Small Proportion ◽  
Radical Scavenger ◽  
Grignard Reaction ◽  
Radical Trapping ◽  
Methylmagnesium Iodide ◽  
Trapping Agent

A versatile free-radical trapping agent, 1,1,3,3-tetramethylisoindolin-2-yloxyl, has been prepared from N-benzylphthalimide by reaction with 'methylmagnesium iodide' in refluxing toluene followed by hydrogenolysis and oxidation. The Grignard reaction gives 2-benzyl-1,1,3,3-tetramethylisoindoline along with a small proportion of an unexpected by-product, 2-benzyl-1-ethyl-1,3,3-trimethyliso-indoline.

scholarly journals New Method in Free Radical Chemistry Using 2,4-Diphenyl-4-methyl-1-pentene as Radical Trapping Agent

1997 ◽  
Vol 29 (4) ◽  
pp. 366-369 ◽  
Author(s):  
Yasumasa Watanabe ◽  
Hideyo Ishigaki ◽  
Hiroshi Okada ◽  
Shuji Suyama
Keyword(s):  
Free Radical ◽  
New Method ◽  
Radical Chemistry ◽  
Radical Trapping ◽  
Free Radical Chemistry ◽  
Trapping Agent

Pharmacokinetics of NXY-059, a nitrone-based free radical trapping agent, in healthy young and elderly subjects

2002 ◽  
Vol 11 (1) ◽  
pp. 34-42 ◽  
Author(s):  
Charlotte Edenius ◽  
Stig Strid ◽  
Olof Borgå ◽  
Anna Breitholtz-Emanuelsson ◽  
Kerstin Lanbeck Vallén ◽  
...  
Keyword(s):  
Free Radical ◽  
Elderly Subjects ◽  
Radical Trapping ◽  
Young And Elderly Subjects ◽  
Trapping Agent

Efficacy of disodium 4-[(tert-butylimino)methyl]benzene-1,3-disulfonate N-oxide (NXY-059), a free radical trapping agent, in a rat model of hemorrhagic stroke

2001 ◽  
Vol 40 (3) ◽  
pp. 433-439 ◽  
Author(s):  
James Peeling ◽  
Marc R Del Bigio ◽  
Dale Corbett ◽  
A.Richard Green ◽  
David M Jackson
Keyword(s):  
Free Radical ◽  
Rat Model ◽  
Hemorrhagic Stroke ◽  
Radical Trapping ◽  
Trapping Agent ◽  
Methyl Benzene

scholarly journals NXY-059, a Free Radical–Trapping Agent, Substantially Lessens the Functional Disability Resulting From Cerebral Ischemia in a Primate Species

Stroke ◽  
2001 ◽  
Vol 32 (1) ◽  
pp. 190-198 ◽  
Author(s):  
Jonathan W. B. Marshall ◽  
Katharine J. Duffin ◽  
A. Richard Green ◽  
Rosalind M. Ridley
Keyword(s):  
Free Radical ◽  
Cerebral Ischemia ◽  
Functional Disability ◽  
Primate Species ◽  
Radical Trapping ◽  
Trapping Agent

Pharmacokinetics in renally impaired subjects of NXY-059, a nitrone-based, free-radical trapping agent developed for the treatment of acute stroke

2002 ◽  
Vol 58 (6) ◽  
pp. 409-415 ◽  
Author(s):  
Stig Strid ◽  
Olof Borgå ◽  
Charlotte Edenius ◽  
Karl-Gustav Jostell ◽  
Tomas Odergren ◽  
...  
Keyword(s):  
Free Radical ◽  
Acute Stroke ◽  
Radical Trapping ◽  
Trapping Agent

OPTIMASI KONDISI EKSTRAKSI SENYAWA AKTIF ANTIOKSIDAN DARI BIJI ANGGUR

2019 ◽  
Vol 3 (2) ◽  
pp. 35
Author(s):  
Kartini Kartini ◽  
Azminah Azminah
Keyword(s):  
Free Radical ◽  
Optimum Condition ◽  
Active Compound ◽  
Grape Seed ◽  
Free Radical Scavenger ◽  
Water Bath ◽  
Radical Scavenger ◽  
Optimum Conditions ◽  
Ethanolic Solution ◽  
Reduced Pressure

In order to prepare standardized extract, optimization of extraction conditions of grape seed has been done. These conditions are type of menstrum (50, 70 and 96% of ethanolic solution), length of extraction (1, 2 and 4 hours) also method of evaporation (reduced pressure and opened air). Activity on free radical scavenger used as parameters to determine optimum conditions. Based on EC50 (concentration which scavenge 50% amount of free radical) can be concluded that optimum condition for extracting antioxidant active compound from grape seed are 70% ethanolic solution as menstrum, length of extraction 1 hour and evaporation on opened air use water bath.

Sign in / Sign up

Export Citation Format

Share Document