Chemistry of the Coccoidea. IX. Pigments from the lac insect Austrotachardia acaciae (Hemiptera) and associated synthetic work

1981 ◽  
Vol 34 (11) ◽  
pp. 2481 ◽  
Author(s):  
DW Cameron ◽  
GI Feutrill ◽  
RL Karge ◽  
AF Patti
Keyword(s):  
Aluminium Chloride ◽  
Methyl Groups ◽  
Lac Insect ◽  
Derivatives Of ◽  
Synthetic Work

Minor pigments of the lacciferid Austrotachardia acaciae Maskell include isoerythrolaccin and the new 7-hydroxyerythrolaccin whose structure was confirmed by synthesis. Severe treatment of certain derivatives of 1,3-dihydroxyanthraquinone with aluminium chloride has resulted in novel deoxygenation to the 1-hydroxy series. The 1,2-dimethyl anthraquinones, 3,6,8-trihydroxy-1,2-dimethylanthraquinone and 3,6,7,8-tetrahydroxy-1,2-dimethylanthraquinone, have been synthesized. Oxidation of the methyl groups has been explored as a possible route to the synthesis of the major pigment from A. acaciae, xantholaccaic acid B.

scholarly journals Synthesis of 3-Ferrocenyl Isocoumarins

2020 ◽  
Vol 36 (05) ◽  
pp. 976-979
Author(s):  
Neeta Sinha
Keyword(s):  
Spectral Analysis ◽  
Melting Point ◽  
Phosphoric Acid ◽  
Polyphosphoric Acid ◽  
Aluminium Chloride ◽  
Melting Point Determination ◽  
Anhydrous Aluminium Chloride ◽  
Point Determination ◽  
Derivatives Of

The derivatives of 3-ferrocenyl isocoumarin were synthesized by the condensation of substituted homothphalic anhydride with ferrocene using phosphoric acid or anhydrous aluminium chloride as cyclising agent. Substituted homophthalic acid did not condense with ferrocene so homophthalic acids were converted into their anhydride and then allowed to react with ferrocene in the presence of polyphosphoric acid or in the presence of anhydrous aluminium chloride using dichloromethane as the solvent to give 3-ferrocenyl isocoumarins. 7-Methoxy, 6-methyl, 5,7-dihydroxy, 6,7-dimethoxy and 5,7-dimethoxy derivatives of 3-ferrocenyl isocoumarin were synthesized. All the compounds were characterised by melting point determination, elemental and spectral analysis.

Alkaloids of the Australian Rutaceae: Melicope fareana. IV. Some Reactions of 1-Methyl-4-quinolone-3-carboxyic Acid, a Degradation Product of the Alkaloids

1949 ◽  
Vol 2 (2) ◽  
pp. 272 ◽  
Author(s):  
JR Price
Keyword(s):  
Nitric Acid ◽  
Carboxylic Acid ◽  
Hydrochloric Acid ◽  
Degradation Product ◽  
Carboxyl Groups ◽  
Methyl Groups ◽  
Derivatives Of

Melicopine, melicopidine, and melicopicine are each oxidized by nitric acid to the same acid, C11H9O3N. Decarboxylation gives 1-methyl-4-quinolone (I) and the acid is shown to be 1-methyl-4-quinolone-3-carboxylic acid (II). The 3- and 6- mononitro-, 3,6-dinitro-, and 2-hydroxy-3,6-dinitro- derivatives of 1-methyl-4-quinolone have been prepared and the orientation of the substituents established by oxidation of the hydroxydinitro- compound to 5-nitro-N-methylanthranilic acid. 1-Methy1-4-quinolone-3-carboxylic acid is readily converted to a tetrahydro- derivative. The carboxyl groups in II and in the tetrahydro- acid are reduced by zinc and hydrochloric acid to methyl groups.

SYNTHESIS OF DERIVATIVES OF 1,2-DICHLORO-4-BENZENESULFONAMIDO-5-NITROBENZENE AND THEIR USE IN THE CHEMOTHERAPY OF SPONTANEOUS CANCERS

1965 ◽  
Vol 43 (5) ◽  
pp. 1454-1459 ◽  
Author(s):  
D. W. Woolley ◽  
T. Van Der Hoeven
Keyword(s):  
Active Substance ◽  
Quaternary Ammonium ◽  
Water Solubility ◽  
Parent Compound ◽  
Para Position ◽  
Methyl Groups ◽  
Chlorine Atoms ◽  
Derivatives Of ◽  
Ionizable Groups

A series of compounds related to 1,2-dichloro-4-benzenesulfonamido-5-nitrobenzene has been synthesized. These included derivatives in which ionizable groups had been placed in the para position of the benzenesulfonamido portion to confer on the compounds water solubility at physiological pH. Thus, carboxyl and quaternary ammonium groupings were introduced in this position. Water solubility was also conferred by introduction at the same position of non-ionizable groups such as polyhydroxyalkylamido groups. Additional relatives of the parent compound in which the chlorine atoms were replaced by methyl groups, and in which para-substituted benzenesulfonamido groups replaced those in the 4 and 5 positions, were synthesized. These compounds were tested for their ability to cure permanently the spontaneous mammary cancers of two strains of mice. All compounds were tested in combination with 1,2-dimethyl-4-(p-carboxyphenylazo)-5-hydroxybenzene. The most active substance found was 1,2-dichloro-4-(p-carboxybenzenesulfonamido)-5-nitrobenzene.

13C Nuclear Magnetic Resonance Studies of Organometallic Compounds. IV. cis-Dimethylplatinum(II) Derivatives

1974 ◽  
Vol 52 (7) ◽  
pp. 1165-1170 ◽  
Author(s):  
Howard Charles Clark ◽  
Leo Ernest Manzer ◽  
John Edward Henry Ward
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Organometallic Compounds ◽  
Methyl Groups ◽  
Magnetic Resonance Studies ◽  
Trans Influence ◽  
13C Nuclear Magnetic Resonance ◽  
Cis And Trans ◽  
Derivatives Of ◽  
Nuclear Magnetic

Data derived from the 13C n.m.r. spectra of seven neutral cis-dimethylplatinum(II) derivatives of the type cis-(CH3)2PtL2 and cis-(CH3)2Pt(L—L) (where L and L—L are neutral donors) are discussed and compared with data derived from the 1H n.m.r. spectra of the complexes. Simultaneous variations in L or L—L reveal that the n.m.r. trans-influence rather than the n.m.r. cis-influence is dominant. The suggestion that the n.m.r. cis- and trans-influences may be additive is discussed. In contrast with data obtained by other workers, it is shown that the 1JCH values of the platinum methyl groups are essentially insensitive to variations in the remaining ligands.

5-Cinnamoyl- and 5-(Ethoxycarbonyl)-6-styryl Derivatives of 4-Aryl-3,4-dihydropyrimidin-2(1H)-ones

2007 ◽  
Vol 72 (9) ◽  
pp. 1219-1228 ◽  
Author(s):  
Maksim A. Kolosov ◽  
Valeriy D. Orlov ◽  
Valeriy V. Vashchenko ◽  
Svetlana V. Shishkina ◽  
Oleg V. Shishkin
Keyword(s):  
Physicochemical Properties ◽  
Alkyl Substituent ◽  
Methyl Groups ◽  
Schmidt Reaction ◽  
Acetyl Group ◽  
Derivatives Of

Several 5-cinnamoyl- and 5-(ethoxycarbonyl)-6-styryl derivatives of 4-aryl-3,4-dihydropyrimidin-2(1H)-ones were obtained and their physicochemical properties were investigated. The introduction of alkyl substituent in position 1 of dihydropyrimidine ring was shown to promote the Claisen-Schmidt reaction on acetyl group only; without the alkyl both acetyl and 6-methyl groups participate in the reaction.

scholarly journals Synthesis of enantiomerically enriched (R)-13C-labelled 2-aminoisobutyric acid (Aib) by conformational memory in the alkylation of a derivative of L-alanine

2011 ◽  
Vol 7 ◽  
pp. 1304-1309 ◽  
Author(s):  
Stephen P Fletcher ◽  
Jordi Solà ◽  
Dean Holt ◽  
Robert A Brown ◽  
Jonathan Clayden
Keyword(s):  
Amino Acids ◽  
Absolute Configuration ◽  
Enantiomeric Purity ◽  
Methyl Groups ◽  
Aminoisobutyric Acid ◽  
The Absolute ◽  
Conformational Memory ◽  
Enantioselective Alkylation ◽  
Derivatives Of

The method of Kouklovsky and coworkers for the enantioselective alkylation of cyclic N-naphthoyl derivatives of amino acids was used to introduce a 13C label into one of the two enantiotopic methyl groups of 2-aminoisobutyric acid (Aib) by retentive alkylation of L-alanine with 13CH3I. Conditions were identified for optimization of yield and enantiomeric purity, and the absolute configuration of the labelled product was established.

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