Abnormal behaviour of 8b,8c,9,11,11a,11b-Hexahydro- and 8c,9,11,11a-Tetrahydro-phenanthro[9',10':3,4]cyclobuta[1,2-c]furan during bromination with N-bromosuccinimide

1977 ◽  
Vol 30 (6) ◽  
pp. 1275 ◽  
Author(s):  
RK McCulloch ◽  
MB Stringer ◽  
D Wege
Keyword(s):  
Abnormal Behaviour ◽  
Unusual Fragmentation

Dimethyl 1,2,2a,10b-tetrahydrocyclobuta[l]phenantene-cis-1,2- dicarboxylate has been converted into 8b,8c,9,11,11a,11b- hexahydrophenanthro[9?,10?:3,4]cyclobuta[1,2-c]furan (9) and 8c,9,11,11a-tetrahydrophenanthro[9?,10?:3,4]cyclobuta[1,2-c]furan (5) by a series of standard reactions. Bromination of (9) with N- bromosuccinimide gave 3-bromo-4-(9?-phenanthryl)tetrahydrofuran (14) by an unusual fragmentation of the cyclobutyl ring. Reaction of (5) with N-bromosuccinimide resulted in the introduction of the N-succinimyl substituents into the α-position of the tetrahydrofuran ring.

Acquired Disorder of Platelet Function Associated with Autoantibodies against Membrane Glycoprotein IIb-IIIa Complex - 1. Glycoprotein Analysis

1991 ◽  
Vol 65 (05) ◽  
pp. 491-496 ◽  
Author(s):  
M Meyer ◽  
C M Kirchmaier ◽  
A Schirmer ◽  
P Spangenberg ◽  
Ch Ströhl ◽  
...  
Keyword(s):  
Platelet Count ◽  
Platelet Aggregation ◽  
Platelet Adhesion ◽  
Bleeding Time ◽  
Membrane Glycoprotein ◽  
Membrane Glycoproteins ◽  
Abnormal Behaviour ◽  
Thrombocytopenic Purpura ◽  
Immunoelectrophoretic Analysis ◽  
Prolonged Bleeding Time

SummaryA patient with idiopathic thrombocytopenic purpura developed after splenectomy a thrombasthenia-like severe haemor-rhagic diathesis characterized by a normal or subnormal platelet count, prolonged bleeding time, strongly reduced platelet adhesion to glass and defective platelet aggregation in response to ADP and collagen. In contrast to hereditary thrombasthenia membrane glycoproteins (GP) lib and Ilia were normally present in the patient’s platelets. Immunoelectrophoretic analysis revealed an abnormal behaviour of the patient’s GP IIb-IIIa complex. Autoantibodies against GP IIb-IIIa were detected in Triton-extracted washed platelets. Incubation of normal platelets with plasma from the patient resulted in a similar immunoelectrophoretic abnormality of the GP IIb-IIIa complex indicating that bound autoantibodies (IgG) are responsible for the abnormal immunoelectrophoretic behaviour of the patient’s GP IIb-IIIa complex. Platelet fibrinogen was severely reduced similar to classical thrombasthenia suggesting that the GP IIb-IIIa complex is involved in platelet fibrinogen storage.

scholarly journals Recommendations for Abnormal Behaviour Ethograms in Monkey Research

Animals ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1461
Author(s):  
Andrea Polanco ◽  
Brenda McCowan ◽  
Lee Niel ◽  
David L. Pearl ◽  
Georgia Mason
Keyword(s):  
Macaca Mulatta ◽  
Regression Models ◽  
Convergent Validity ◽  
P Value ◽  
Morphological Similarity ◽  
Abnormal Behaviour ◽  
Logistic Regression Models ◽  
The Third ◽  
Welfare Implications ◽  
Self Stimulation

Laboratory monkey ethograms currently include subcategories of abnormal behaviours that are based on superficial morphological similarity. Yet, such ethograms may be misclassifying behaviour, with potential welfare implications as different abnormal behaviours are likely to have distinct risk factors and treatments. We therefore investigated the convergent validity of four hypothesized subcategories of abnormal behaviours (‘motor’, e.g., pacing; ‘self-stimulation’, e.g., self-sucking; ‘postural’, e.g., hanging; and ‘self-abuse’, e.g., self-biting). This hypothesis predicts positive relationships between the behaviours within each subcategory. Rhesus macaque (Macaca mulatta) data on 19 abnormal behaviours were obtained from indoor-housed animals (n = 1183). Logistic regression models, controlling for sex, age, and the number of observations, revealed that only 1/6 ‘motor’ behaviours positively predicted pacing, while 2/3 ‘self-abuse’ behaviours positively predicted self-biting (one-tailed p-value < 0.05). Furthermore, ‘self-stimulation’ behaviours did not predict self-sucking, and none of the ‘postural’ behaviours predicted hanging. Thus, none of the subcategories fully met convergent validity. Subsequently, we created four new valid subcategories formed of comorbid behaviours. The first consisted of self-biting, self-hitting, self-injurious behaviour, floating limb, leg-lifting, and self-clasping. The second comprised twirling, bouncing, rocking, swinging, and hanging. The third comprised pacing and head-twisting, while the final subcategory consisted of flipping and eye-poking. Self-sucking, hair-plucking, threat-biting, and withdrawn remained as individual behaviours. We encourage laboratories to replicate the validation of these subcategories first, and for scientists working with other species to validate their ethograms before using them in welfare assessments.

Klinefelter's Syndrome with Atypical Presenting Features

1981 ◽  
Vol 26 (8) ◽  
pp. 567-568 ◽  
Author(s):  
V.K. Yeragani ◽  
G. Hopkinson
Keyword(s):  
Personality Disorder ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Klinefelter’S Syndrome ◽  
Klinefelter's Syndrome ◽  
Abnormal Behaviour ◽  
Hearing Voices ◽  
Rule Out ◽  
As If

The authors thought it would be of interest to present this case which proved to be Klinefelter's syndrome with “xxy” pattern, as the patient presented with episodes of abnormal behaviour lasting for a few minutes. He would suddenly become anxious, look perplexed, start clenching his fists and at times complain of thoughts that some persons were trying to attack him. He also felt as if he were hearing voices talking to him. Observation in the hospital and EEG recording helped to rule out temporal lobe epilepsy and a diagnosis of Klinefelter's syndrome with personality disorder and psychogenic attacks of abnormal behaviour was made at the time of discharge.

Abnormal behaviour in cats

1988 ◽  
Vol 65 (12) ◽  
pp. 395-396 ◽  
Author(s):  
JK BLACKSHAW
Keyword(s):  
Abnormal Behaviour

scholarly journals Natural kinds of mental disorder

Synthese ◽  
2021 ◽  
Author(s):  
Sander Werkhoven
Keyword(s):  
Mental Health ◽  
Mental Disorders ◽  
Mental Disorder ◽  
Mental Health Problems ◽  
Natural Kinds ◽  
Health Problems ◽  
Abnormal Behaviour ◽  
Diagnostic Categories ◽  
Socially Constructed

AbstractAre mental disorders (autism, ADHD, schizophrenia) natural kinds or socially constructed categories? What is at stake if either of these views prove to be true? This paper offers a qualified defence for the view that there may be natural kinds of mental disorder, but also that the implications of this claim are generally overestimated. Especially concerns about over-inclusiveness of diagnostic categories and medicalisation of abnormal behaviour are not addressed by the debate. To arrive at these conclusions the paper opens with a discussion of kind formation in science, followed by an analysis of natural kinds. Seven principled and empirically informed objections to the possibility of natural kinds of mental disorder are considered and rejected. The paper ends with a reflection on diagnostics of mental health problems that don’t fall into natural kinds. Despite the defence of the possibility of natural kinds of mental disorder, this is likely to be the majority of cases.

scholarly journals Evaluation of an enrichment programme for a colony of long-tailed macaques (Macaca fascicularis) in a rescue centre

Primates ◽  
2021 ◽  
Author(s):  
Valeria Albanese ◽  
Michela Kuan ◽  
Pier Attilio Accorsi ◽  
Roberta Berardi ◽  
Giovanna Marliani
Keyword(s):  
Animal Models ◽  
Biomedical Research ◽  
Macaca Fascicularis ◽  
Activity Budget ◽  
Control Session ◽  
Abnormal Behaviour ◽  
Species Specific ◽  
Low Rate

AbstractLong-tailed macaques are highly social primates that are commonly used in biomedical research as animal models. The aim of this study was to evaluate the effects of different kinds of enrichment on the behaviour and faecal cortisol metabolite (FCM) level in a colony of ex-laboratory long-tailed macaques during a programme of rehabilitation. The research was carried out in three periods, divided into two sessions each. Every period was composed of one control session (SC) and one session characterised by one type of enrichment: feeding enrichment (FE), manipulative enrichment (ME), and the last session during which manipulative and feeding enrichment were provided every day but in a mixed way (MIX). The results showed that manipulative and mixed enrichments caused positive changes to the activity budget of the colony, with a decrease in abnormal behaviour rates and an increase in play compared with control sessions. The rate of affiliative behaviours and low rate of aggression were probably because the group was composed mostly of females and it was stable, with a well-defined hierarchy. The research underlines the importance of a well-studied enrichment programme for the welfare of captive animals, which should exploit species-specific motivations.

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